Viable tissue repair implants and methods of use
First Claim
1. A biocompatible tissue implant for repairing a tissue injury or defect, comprising:
- (a) an isolated biological tissue slice harvested from healthy tissue, the tissue slice having a geometry suitable for implantation at a tissue site, the tissue slice dimensioned and capable of acting as a cell source that allows viable cells to migrate out of the tissue slice and to proliferate and integrate with tissue at the tissue injury or defect;
(b) at least one minced tissue fragment containing a plurality of viable cells that can migrate from the tissue fragment, wherein the at least one minced tissue fragment is combined with the isolated biological tissue slice; and
(c) a retaining element for securing the tissue slice to the tissue site.
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Accused Products
Abstract
Biocompatible tissue implants are provided for repairing a tissue injury or defect. The tissue implants comprise a biological tissue slice that serves as a source of viable cells capable of tissue regeneration and/or repair. The biological tissue slice can be harvested from healthy tissue to have a geometry that is suitable for implantation at the site of the injury or defect. The harvested tissue slice is dimensioned to allow the viable cells contained within the tissue slice to migrate out and proliferate and integrate with tissue surrounding the injury or defect site. Methods for repairing a tissue injury or defect using the tissue implants are also provided.
330 Citations
25 Claims
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1. A biocompatible tissue implant for repairing a tissue injury or defect, comprising:
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(a) an isolated biological tissue slice harvested from healthy tissue, the tissue slice having a geometry suitable for implantation at a tissue site, the tissue slice dimensioned and capable of acting as a cell source that allows viable cells to migrate out of the tissue slice and to proliferate and integrate with tissue at the tissue injury or defect; (b) at least one minced tissue fragment containing a plurality of viable cells that can migrate from the tissue fragment, wherein the at least one minced tissue fragment is combined with the isolated biological tissue slice; and (c) a retaining element for securing the tissue slice to the tissue site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method for repairing a tissue injury or defect, comprising:
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providing;
(i) an isolated biological tissue slice harvested from healthy tissue, having a geometry suitable for implantation at an injury or defect site, and capable of acting as a source of viable cells; and
(ii) at least one minced tissue fragment containing a plurality of viable cells that can migrate from the tissue fragment;applying the at least one minced tissue fragment to the isolated biological tissue slice to form a biocompatible tissue implant; delivering the implant to the tissue site to be repaired; securing the naturally occurring biological tissue slice to the tissue site; and allowing viable cells to migrate out of the biocompatible tissue implant to proliferate and integrate with tissue at the tissue site. - View Dependent Claims (20, 21, 22, 23, 24, 25)
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Specification