Polycationic peptides for cardiovascular therapy

• US 7,901,703 B2
• Filed: 03/23/2007
• Issued: 03/08/2011
• Est. Priority Date: 06/21/2002
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Hossainy, Syed F. A.
• Primary Examiner(s): Azpuru; Carlos A
• Application Number:
  US11/726,883
• Publication Number:
  US 20070166351A1
• Time in Patent Office: 1,446 Days
• Field of Search: None
• US Class Current: 424/423
• CPC Class Codes: A61L 2300/252 Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

Implantable medical devices including polycationic peptide coatings are disclosed.

Claims

1. An implantable medical device comprising a coating, wherein the coating includes a polycationic peptide such that the population of the polycationic peptide is greater in the outermost region of the coating.

2. The implantable medical device according to claim 1, wherein the polycationic peptide comprises poly(L-arginine), poly(D-arginine), poly(D,L-arginine), poly(L-lysine), poly(D-lysine), poly(δ

-guanidino-α

-aminobutyric acid), a mixture of poly(L-arginine) and poly(D-arginine) or a combination thereof.

3. The implantable medical device according to claim 1, wherein the device is a stent.