Materials containing multiple layers of vesicles

• US 7,901,706 B2
• Filed: 10/31/2007
• Issued: 03/08/2011
• Est. Priority Date: 03/13/2002
• Status: Expired due to Fees

• Current Assignee: Alcon Incorporated
• Original Assignee: Novartis Ag
• Inventors: Lally, John Martin, Kotov, Nicholas
• Primary Examiner(s): Kishore; Gollamudi S
• Application Number:
  US11/981,208
• Publication Number:
  US 20080063898A1
• Time in Patent Office: 1,224 Days
• Field of Search: 424/429, 424/450
• US Class Current: 424/429
• CPC Class Codes: A61K 9/127 Liposomes
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

The present invention provides a composite material, preferably an ophthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a vesicle and one layer of a polyionic material having charges opposite the charges of the vesicle. Such composite material can find use in biomedical applications, for example, a device for localized drug delivery and an in vivo analyte sensor such as glucose sensing contact lens. By lifting off the vesicle-containing coating from a substrate, a self-standing membrane (film) capable of encapsulating a wide variety of guest materials can be prepared. In addition, the invention provides methods for making vesicle-containing composite and film materials of the present invention.

Claims

1. A method for making a composite material, comprising the steps of:

(a) contacting a bulk material with a dispersion of a vesicle selected from the group consisting of a polymerized liposome, a polymerized micelle, to form a layer of the vesicle on the bulk material;

(b) optionally rinsing said bulk material by contacting said bulk material with a rinsing solution;

(c) contacting said bulk material with a solution of a polyionic material to form a layer of the polyionic material on top of the layer of the vesicle, wherein said polyionic material has charges opposite the charges of the vesicle; and

(d) optionally rinsing said bulk material by contacting said bulk material with the rinsing solution.

2. A method of claim 1, wherein at least one of said contacting occurs by immersion said bulk material in a solution or dispersion.

3. A method of claim 1, wherein at least one of said contacting occurs by spraying a solution or dispersion onto the bulk material.

4. A method of claim 1, wherein said method comprises repeating steps (a) through (d) between 2 to 30 times.

5. A film material, comprising:

at least one layer of a vesicle and one layer of a polyionic material having charges opposite the charges of the vesicle, wherein the vesicle is selected from the group consisting of a polymerized liposome, a polymerized micelle and combination thereof.

6. A film material of claim 5, comprising 2 to 50 layers of each of the vesicle and the polyionic material.

7. A film material of claim 5, wherein said vesicle encapsulates a guest material selected from the group consisting of a biosensor, a drug, a protein, an amino acid, a nucleic acid, a polypeptide, metallic nanoparticles, magnetic nanoparticles, optically active nanoparticles, and dyes.

8. A film material of claim 5, further comprising at least one layer of an additional vesicle.

9. A method for making a film material containing layers of vesicle, comprising:

(1) depositing a plurality of bilayers of a vesicle and a polyionic material having charges opposite the surface charges of the vesicle onto the surface of a substrate to form a film on the substrate, wherein said vesicle is selected from the group consisting of a polymerized liposome, a polymerized micelle, and combination thereof; and

(2) separating the film from the substrate.

10. A method of claim 9, wherein the depositing step comprises solely dip-coating and dip-rinsing sub-steps, solely spray-coating and spray-rinsing sub-steps, or a combination of spray-coating, spray-rinsing, dip-coating and dip-rinsing sub-steps.