Brain stimulation models, systems, devices, and methods
First Claim
1. A computer-assisted method for determining a volume of influence by an electrode inserted in neural tissue in a patient, comprising:
- configuring a mathematical model of the electrode inserted inside the neural tissue, wherein the mathematical model comprises a parameter representing a tissue conductivity characteristic of the neural tissue;
solving the mathematical model to calculate a second derivative or an approximation of a second derivative of an electrical potential produced by the electrode under a set of electrode stimulation conditions within the neural tissue;
determining a predicted volume of influence using the second derivative or approximation of the second derivative of the electrical potential; and
displaying the volume of influence on a display screen.
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Abstract
This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. A model computes a volume of influence region for a simulated electrical stimulation using certain stimulation parameters, such as amplitude, pulsewidth, frequency, pulse morphology, electrode contact selection or location, return path electrode selection, pulse polarity, etc. The model uses a non-uniform tissue conductivity. This accurately represents brain tissue, which has highly directionally conductive neuron pathways yielding a non-homogeneous and anisotropic tissue medium. In one example, the non-uniform tissue conductivity is obtained from diffusion tensor imaging (DTI) data. In one example, a second difference of an electric potential distribution is used to define a volume of activation (VOA) or similar volume of influence. In another example, a neuron or axon model is used to calculate the volume of influence without computing the second difference of the electric potential distribution.
221 Citations
72 Claims
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1. A computer-assisted method for determining a volume of influence by an electrode inserted in neural tissue in a patient, comprising:
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configuring a mathematical model of the electrode inserted inside the neural tissue, wherein the mathematical model comprises a parameter representing a tissue conductivity characteristic of the neural tissue; solving the mathematical model to calculate a second derivative or an approximation of a second derivative of an electrical potential produced by the electrode under a set of electrode stimulation conditions within the neural tissue; determining a predicted volume of influence using the second derivative or approximation of the second derivative of the electrical potential; and displaying the volume of influence on a display screen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A non-transitory computer-readable storage medium comprising instructions for:
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configuring a mathematical model of an electrode inserted inside neural tissue of a patient, wherein the mathematical model comprises a parameter representing a tissue conductivity characteristic of the neural tissue; solving the mathematical model to calculate a second derivative or an approximation of a second derivative of an electrical potential produced by the electrode under a set of electrode stimulation conditions within the neural tissue; and determining a predicted volume of influence using the second derivative or approximation of the second derivative of the electrical potential. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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49. A computer system having a display screen, the computer system being programmed to perform steps that comprise:
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configuring a mathematical model of an electrode inserted inside neural tissue of a patient, wherein the mathematical model comprises a parameter representing a tissue conductivity characteristic of the neural tissue; solving the mathematical model to calculate a second derivative or an approximation of a second derivative of an electrical potential produced by the electrode under a set of electrode stimulation conditions within the neural tissue; determining a predicted volume of influence using the second derivative or approximation of the second derivative of the electrical potential; and displaying the volume of influence on the display screen. - View Dependent Claims (50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72)
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Specification