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Small volume in vitro analyte sensor

  • US 7,906,009 B2
  • Filed: 07/30/2008
  • Issued: 03/15/2011
  • Est. Priority Date: 02/06/1997
  • Status: Expired due to Fees
First Claim
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1. A method for determining a concentration of an analyte in a sample from a patient, the method comprising:

  • (a) piercing the patient with a sample acquisition element of an integrated device comprising a sample acquisition element and an electrochemical sensor to obtain a sample;

    (b) transporting no more than 500 nl of the sample into the electrochemical sensor, the sensor comprising;

    (i) a spacer layer;

    (ii) a first inert base having a first electrode thereon, the first base positioned against the spacer layer with the first electrode proximate the spacer layer;

    (iii) a second inert base having a second electrode thereon, the second base positioned against the spacer layer with the second electrode proximate the spacer layer, the first and second electrodes being a facing electrode pair;

    (iv) the spacer layer, first base and second base together defining a sample chamber having a volume of no more than about 500 nl;

    (v) a redox mediator and an enzyme present in the sample chamber; and

    (vi) a tapered tip into which the sample enters, wherein the sample acquisition element faces in the same direction as the tapered tip and is movable in a parallel manner relative to the sensor;

    (c) holding the sample in the sample chamber of the electrochemical sensor in a non-flow through manner; and

    (d) determining the concentration of analyte in the sample by electrochemistry.

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