Optimized dosing for drug coated stents
First Claim
Patent Images
1. A drug coated stent comprising:
- a structural member insertable into a body lumen of a patient; and
a drug coated onto at least a portion of said structural member;
wherein about 60 micrograms or less than 60 micrograms of the drug is released within ten days after insertion into the body lumen of the patient andthe release rate is maximized between 24 hours and three days.
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Abstract
The inventors have found that both the drug dose and drug release profiles are significant factors for the safety and efficacy of drug coated stents. The inventors have identified optimum dosing and release kinetics for drug coated stents. In particular, the inventors have determined dosing and release kinetics that permit the delivery of the lowest effective drug dosage, thus enhancing patient safety and minimizing any side effects from the drug.
116 Citations
13 Claims
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1. A drug coated stent comprising:
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a structural member insertable into a body lumen of a patient; and a drug coated onto at least a portion of said structural member; wherein about 60 micrograms or less than 60 micrograms of the drug is released within ten days after insertion into the body lumen of the patient and the release rate is maximized between 24 hours and three days. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A paclitaxel coated stent comprising:
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a structural member insertable into a body lumen of a patient; and paclitaxel coated onto at least a portion of said structural member; wherein about 10 micrograms or less than 10 micrograms of paclitaxel is released from said stent two days after exposure to an aqueous environment and the release rate is maximized between 24 hours and three days. - View Dependent Claims (12, 13)
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Specification