Therapy-enhancing glucan

• US 7,906,492 B2
• Filed: 01/17/2006
• Issued: 03/15/2011
• Est. Priority Date: 01/16/2001
• Status: Active Grant

• Current Assignee: Sloan-Kettering Institute For Cancer Research (Memorial Sloan-Kettering Cancer Center)
• Original Assignee: Sloan-Kettering Institute For Cancer Research (Memorial Sloan-Kettering Cancer Center)
• Inventors: Cheung, Nai-Kong V.
• Primary Examiner(s): OLSON, ERIC
• Application Number:
  US11/334,763
• Publication Number:
  US 20060160766A1
• Time in Patent Office: 1,883 Days
• Field of Search: None
• US Class Current: 514/54
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 31/739 Lipopolysaccharides
• CPC Class Codes: A61K 39/39 characterised by the immunostimulating additives, e.g. chemical adjuvants
• CPC Class Codes: A61K 39/39558 against tumor tissues, cells, antigens
• CPC Class Codes: A61K 39/44 Antibodies bound to carriers
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 48/00 Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• CPC Class Codes: C08L 5/00 Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00

Abstract

A therapeutic composition for treatment of cancer in a mammal is disclosed. The composition comprises an effective amount of a glucan composition which is suitable for oral administration and for absorption through the gastrointestinal tract of the mammal, and at least one antibody for the cancer. A method of treating cancer in a mammal is also disclosed. The method comprises administering a suitable orally administered glucan and at least one antibody for the treatment of cancer to the mammal. In addition a composition for delivery of peptide, protein, RNA, DNA or plasmid comprising effective amount of a beta-glucan is disclosed.

Claims

1. A delivery composition comprising an isolated DNA, RNA or plasmid and an effective amount of a barley β

-glucan for delivery of said DNA, RNA or plasmid into cells, wherein said β

-glucan is not encapsulated, and has an average molecular weight of about 15 to about 350 kD.

2. The composition of claim 1, wherein the glucan comprises β

-1,4 bonds in the backbone.

3. The composition of claim 2, wherein the glucan further comprises β

-1,3 bonds in the backbone.

4. The composition of claim 1, wherein the glucan comprises β

-1,3 bonds in the backbone.

5. The composition of claim 1 wherein the glucan is a particulate or soluble glucan.

6. The composition of claim 1 wherein the composition is formulated for oral administration.

7. A composition for delivering a DNA, RNA or plasmid into a cell consisting essentially of said DNA, RNA or plasmid, and an effective amount of a barley β

-glucan, wherein said β

-glucan has an average molecular weight of about 15 to about 350 kD.

8. The composition of claim 7, wherein the glucan comprises β

-1,4 bonds in the backbone.

9. The composition of claim 8, wherein the glucan further comprises β

-1,3 bonds in the backbone.

10. The composition of claim 7, wherein the glucan comprises β

-1,3 bonds in the backbone.

11. The composition of claim 7, wherein the glucan is a particulate or soluble glucan.

12. The composition of claim 7, wherein the composition is formulated for oral administration.