Integrated sensing module for handheld spectral measurements

• US 7,907,282 B2
• Filed: 06/10/2008
• Issued: 03/15/2011
• Est. Priority Date: 08/14/2003
• Status: Active Grant

• Current Assignee: George N. Appell
• Original Assignee: Microptix Technologies, LLC
• Inventors: Coates, John
• Primary Examiner(s): Evans; Fannie L.
• Application Number:
  US12/136,219
• Publication Number:
  US 20080265146A1
• Time in Patent Office: 1,008 Days
• Field of Search: 356/51, 356/419
• US Class Current: 356/419
• CPC Class Codes: G01J 3/02 Details
• CPC Class Codes: G01J 3/0259 Monolithic
• CPC Class Codes: G01J 3/0264 Electrical interface; User interface
• CPC Class Codes: G01J 3/0267 Sample holders for colorimetry
• CPC Class Codes: G01J 3/0272 Handheld
• CPC Class Codes: G01J 3/0291 Housings; Spectrometer accessories; Spatial arrangement of elements, e.g. folded path arrangements
• CPC Class Codes: G01J 3/2803 using photoelectric array detector
• CPC Class Codes: G01J 3/51 using colour filters
• CPC Class Codes: G01J 3/513 having fixed filter-detector pairs
• CPC Class Codes: G01N 2021/6417 Spectrofluorimetric devices
• CPC Class Codes: G01N 2035/1062 for testing the liquid while it is in the transfer device
• CPC Class Codes: G01N 21/255 Details, e.g. use of specially adapted sources, lighting or optical systems
• CPC Class Codes: G01N 21/274 Calibration, base line adjustment, drift correction
• CPC Class Codes: G01N 21/4738 Diffuse reflection precedence is given to G01N21/55 - G01N21/57 if specular component is taken into consideration, e.g. also for testing fluids, fibrous materials
• CPC Class Codes: G01N 21/645 Specially adapted constructive features of fluorimeters
• CPC Class Codes: G01N 21/8483 Investigating reagent band test-element handling not specific to a test method G01N33/4875; analytical elements specific to chemical analysis of biological material G01N33/52; autometer with reagent band G01N35/04
• CPC Class Codes: G01N 21/85 Investigating moving fluids or granular solids

Abstract

An integrated spectral sensing engine featuring energy sources and detectors within a single package includes sample interfacing optics and acquisition and processing electronics. The miniaturized sensor is optimized for specific laboratory and field-based measurements by integration into a handheld format. Design and fabrication components support high volume manufacturing. Spectral selectivity is provided by either continuous variable optical filters or filter matrix devices. The sensor'"'"'s response covers the range from 200 nm to 25 μm based on various solid-state detectors. The wavelength range can be extended by the use of filter-matrix devices. Measurement modes include transmittance/absorbance, turbidity (light scattering) and fluorescence (emission). On board data processing includes raw data acquisition, data massaging and the output of computed results. Sensor applications include water and environmental, food and beverage, chemical and petroleum, and medical analyses. These can be expanded into various field and consumer-based applications.

Claims

1. An integrated sensing module, said sensing module comprising:

an optical filter assembly and a light or energy sensitive array, the optical filter assembly and the light or energy sensitive array forming a solid-state device either matched directly in spectral response to a source, or capable of responding to wavelengths over a broad spectral range from one or more sources, the optical filter assembly and the light or energy sensitive array being aligned for direct coupling to one another thereby forming interfacing optics and preserving spectral resolution of the optical filter assembly;

system optics;

one or more on-board processors; and

a memory for storing reference spectral data recorded in the absence of analyte material, the reference spectral data being used to provide a ratio of energy detected by a sample measurement and energy obtained from the reference spectral data, thereby providing a direct measure of the energy absorbed by the sample and system optics.

2. An integrated sensing module, said sensing module comprising:

an optical filter assembly and a light or energy sensitive array, the optical filter assembly and the light or energy sensitive array forming a solid-state device either matched directly in spectral response to a source, or capable of responding to wavelengths over a broad spectral range from one or more sources, the optical filter assembly and the light or energy sensitive array being aligned for direct coupling to one another thereby forming interfacing optics and preserving spectral resolution of the optical filter assembly;

a memory for storing reference spectral data; and

wherein the reference spectral data recorded represents optical interaction of multiple analytes, thereby enabling more than one analysis to be performed, or where a more complex analysis is performed in the event that a condition being monitored provides different independent responses at different wavelengths, the sensing module providing an output for either multiple components or measurement of a complex condition by use of modeling techniques.

3. An integrated sensing module, said sensing module comprising:

an optical filter assembly and a light or energy sensitive array, the optical filter assembly and the light or energy sensitive array forming a solid-state device either matched directly in spectral response to a source, or capable of responding to wavelengths over a broad spectral range from one or more sources, the optical filter assembly and the light or energy sensitive array being aligned for direct coupling to one another thereby forming interfacing optics and preserving spectral resolution of the optical filter assembly;

a processor for processing the signal produced from the light or energy sensitive array; and

an on-board memory for storing calibration coefficient data for simple and complex calibrations, including simple linear response calibrations, second order and higher response calibrations, multivariate models for complex calibrations and/or multicomponent analyses, and storage of methods linked to said calibration coefficient data.

4. An integrated sensing module, said sensing module comprising:

an optical filter assembly and a light or energy sensitive array, the optical filter assembly and the light or energy sensitive array forming a solid-state device either matched directly in spectral response to a source, or capable of responding to wavelengths over a broad spectral range from one or more sources, the optical filter assembly and the light or energy sensitive array being aligned for direct coupling to one another thereby forming interfacing optics and preserving spectral resolution of the optical filter assembly;

a processor for processing the signal produced by the light or energy sensitive array; and

an on-board memory for storing multiple spectra, multiple calibrations, and multiple methods using said calibrations.

5. An integrated sensing module, said sensing module comprising:

an optical filter assembly and a light or energy sensitive array, the optical filter assembly and the light or energy sensitive array forming a solid-state device either matched directly in spectral response to a source, or capable of responding to wavelengths over a broad spectral range from one or more sources, the optical filter assembly and the light or energy sensitive array being aligned for direct coupling to one another thereby forming interfacing optics and preserving spectral resolution of the optical filter assembly;

a processor for processing the signal produced by the light or energy sensitive array; and

an on-board memory for storing pre-loaded or downloaded calibration coefficients for defined methods, the methods being fully defined to include data acquisition parameters, data pre- and post processing, numerical calculations and data transfer and/or display.

6. The sensing module of claim 5, wherein downloading is carried out directly via a built-in serial interface, or over an optional wireless communications interface.

7. An integrated sensing module, said sensing module comprising:

an optical filter assembly and a light or energy sensitive array, the optical filter assembly and the light or energy sensitive array forming a solid-state device either matched directly in spectral response to a source, or capable of responding to wavelengths over a broad spectral range from one or more sources, the optical filter assembly and the light or energy sensitive array being aligned for direct coupling to one another thereby forming interfacing optics and preserving spectral resolution of the optical filter assembly; and

a processor having at least one of;

a computation means for performing computations including concentration calculations;

means for processing of intelligent sensor outputs;

support for standard data formats, standard protocols and standard forms of communications, including serial and bus-oriented communications formats; and

support of hardware based and wireless based communications protocols.

8. An integrated sensing module, said sensing module comprising:

an optical filter assembly and a light or energy sensitive array, the optical filter assembly and the light or energy sensitive array forming a solid-state device either matched directly in spectral response to a source, or capable of responding to wavelengths over a broad spectral range from one or more sources, the optical filter assembly and the light or energy sensitive array being aligned for direct coupling to one another thereby forming interfacing optics and preserving spectral resolution of the optical filter assembly;

the sensing module being formed in combination with and integrated into a fully self-contained handheld device configured to operate with disposable components selected based on application and method required for measurement; and

wherein the disposable components are in the form of tips and/or samplers, where specific reagents are integrated into each body of the tips or within each measurement cavity of the samplers.

9. An integrated sensing module, said sensing module comprising:

an optical filter assembly and a photodiode, the optical filter assembly and the photodiode forming a solid-state device either matched directly in spectral response to a source, or capable of responding to wavelengths over a broad spectral range from one or more sources, the optical filter assembly and the photodiode being aligned for direct coupling to one another thereby forming interfacing optics and preserving spectral resolution of the optical filter assembly; and

the sensing module being formed in combination with and integrated into a fully self-contained handheld device configured as a surface measurement device with an open-ended sample tip.

10. The sensing module of claim 9, wherein the optical filter assembly is a continuous linear variable filter.

11. The sensing module of claim 9, wherein the optical filter assembly is a filter array.

12. The sensing module of claim 11, wherein the filter array is a patterned filter.

13. The sensing module of claim 11, wherein the filter array is a mosaic filter.

14. The handheld device of claim 9, wherein the surface measurement device is configured for reflectance and/or transflectance measurements from a surface.

15. The handheld device of claim 14, wherein the surface measurement device is further configured for measurement of bio-materials in medical applications.

16. An integrated sensing module, said sensing module comprising:

an optical filter assembly and a complementary metal-oxide semiconductor (CMOS) array detector package, said optical filter assembly and said CMOS array detector package forming a solid-state device either matched directly in spectral response to a source, or capable of responding to wavelengths over a broad spectral range from one or more sources, said optical filter assembly and said CMOS array detector package being aligned for direct coupling to one another thereby forming interfacing optics and preserving spectral resolution of the optical filter assembly; and

the sensing module being formed in combination with and integrated into a fully self-contained handheld device configured as a surface measurement device with an open-ended sample tip.

17. The sensing module of claim 16, wherein the optical filter assembly is a continuous linear variable filter.

18. The sensing module of claim 16, wherein the optical filter assembly is a filter array.

19. The sensing module of claim 18, wherein the filter array is a patterned filter.

20. The sensing module of claim 18, wherein the filter array is a mosaic filter.

21. The handheld device of claim 16, wherein the surface measurement device is configured for reflectance and/or transflectance measurements from a surface.

22. The handheld device of claim 21, wherein the surface measurement device is further configured for measurement of bio-materials in medical applications.