System for delivering conformal radiation therapy while simultaneously imaging soft tissue
First Claim
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1. A radiation treatment system, comprising:
- an irradiating device configured to deliver ionizing radiation to a subject from one or more external cobalt 60 radioisotope sources;
a magnetic resonance imaging system operably engaged with the irradiating device, the magnetic resonance imaging system configured to acquire magnetic resonance imaging data from the subject; and
a controller in communication with the irradiating device and the magnetic resonance imaging system such that the controller substantially simultaneously(a) controls the irradiating device to deliver ionizing radiation to the subject; and
(b) controls the magnetic resonance imaging system to acquire magnetic resonance imaging data from the subject.
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Abstract
A device and a process for performing high temporal- and spatial-resolution MR imaging of the anatomy of a patient during intensity modulated radiation therapy (IMRT) to directly measure and control the highly conformal ionizing radiation dose delivered to the patient for the treatment of diseases caused by proliferative tissue disorders. This invention combines the technologies of open MRI, multileaf-collimator or compensating filter-based IMRT delivery, and cobalt teletherapy into a single co-registered and gantry mounted system.
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Citations
44 Claims
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1. A radiation treatment system, comprising:
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an irradiating device configured to deliver ionizing radiation to a subject from one or more external cobalt 60 radioisotope sources; a magnetic resonance imaging system operably engaged with the irradiating device, the magnetic resonance imaging system configured to acquire magnetic resonance imaging data from the subject; and a controller in communication with the irradiating device and the magnetic resonance imaging system such that the controller substantially simultaneously (a) controls the irradiating device to deliver ionizing radiation to the subject; and (b) controls the magnetic resonance imaging system to acquire magnetic resonance imaging data from the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method for guiding the delivery of ionizing radiation to a patient using a magnetic resonance imaging system, the method comprising:
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delivering ionizing radiation from one or more external cobalt 60 radioisotope sources; and acquiring magnetic resonance imaging data from the magnetic resonance imaging system, wherein the delivering and acquiring steps are executed substantially simultaneously. - View Dependent Claims (25, 26, 27)
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28. A computer program product for simultaneously controlling a device for delivering ionizing radiation and a magnetic resonance imaging system so as to guide the delivery of ionizing radiation using magnetic resonance imaging data, the computer program product comprising a non-transitory computer-readable storage medium having computer-readable program code portions stored therein, the computer-readable program code portions comprising:
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a first set of computer instructions for delivering ionizing radiation from one or more external cobalt 60 radioisotope sources; a second set of computer instructions for acquiring magnetic resonance imaging data from the magnetic resonance imaging system substantially simultaneously with the delivery of ionizing radiation. - View Dependent Claims (29)
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30. A radiation treatment apparatus for image guided radiotherapy comprising:
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an irradiating apparatus configured to deliver ionizing radiation to a subject from one or more external cobalt 60 radioisotope sources; a magnetic resonance imaging apparatus operably engaged with the irradiating apparatus, the magnetic resonance imaging system configured to acquire magnetic resonance imaging data from the subject; and a controller in communication with the irradiating apparatus and the magnetic resonance imaging apparatus, the controller configured to control the irradiating apparatus to deliver ionizing radiation to the subject, and substantially simultaneously, control the magnetic resonance imaging system to acquire magnetic resonance imaging data from the subject at a frequency sufficient to account for intra-fractional organ movement. - View Dependent Claims (31, 32, 33, 34)
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- 35. A radiation treatment apparatus for simultaneous radiation treatment and imaging of a subject, said apparatus comprising a split solenoid magnetic resonance imaging system, and a shielded co-registered cobalt 60 isotopic radiation source with a multi-leaf collimator intensity modulated radiation therapy unit for axillary rotation about said subject configured for simultaneous radiation treatment and imaging.
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37. A radiation treatment system, comprising:
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an irradiating device configured to deliver ionizing radiation to a subject from one or more external cobalt 60 radioisotope sources; a magnetic resonance imaging system operably engaged with the irradiating device, the magnetic resonance imaging system configured to acquire a sequence of 3D images of the subject fast enough to capture intra-fraction organ motions; a controller in communication with the irradiating device and the magnetic resonance imaging system such that the controller can substantially simultaneously a) control the irradiating device to deliver ionizing radiation to the subject and record delivered radioisotope beam fluences; and b) control the magnetic resonance imaging system to acquire the 3D images of the subject; and a processor configured to determine an actual dose deposition in the subject from the 3D images and the delivered radioisotope beam fluences. - View Dependent Claims (38, 39, 40)
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41. A method of radiation treatment, the method comprising:
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delivering ionizing radiation to a subject from one or more external cobalt 60 radioisotope sources of an irradiating device; acquiring, by a magnetic resonance imaging system operably engaged with the irradiating device, a sequence of 3D images of the subject fast enough to capture intra-fraction organ motions; substantially simultaneously a) controlling the irradiating device to deliver ionizing radiation to the subject and record delivered radioisotope beam fluences; and b) controlling the magnetic resonance imaging system to acquire the 3D images of the subject; and determining, by a processor, actual dose deposition in the subject from the 3D images and the delivered radioisotope beam fluences. - View Dependent Claims (42, 43, 44)
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Specification