Bio-impedance apparatus and method

• US 7,907,998 B2
• Filed: 09/13/2005
• Issued: 03/15/2011
• Est. Priority Date: 07/03/2002
• Status: Active Grant

• Current Assignee: Tel Aviv University Future Technology Development L.P. (Tel Aviv University)
• Original Assignee: Tel Aviv University Future Technology Development L.P. (Tel Aviv University)
• Inventors: Arad (Abboud), Shimon
• Primary Examiner(s): Hindenburg; Max
• Assistant Examiner(s): Dougherty; Sean P
• Application Number:
  US11/225,630
• Publication Number:
  US 20060064029A1
• Time in Patent Office: 2,009 Days
• Field of Search: 600/481, 600/484, 600/506, 600/533, 600/547, 600/561, 600/584, 606/32, 607/17
• US Class Current: 600/547
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/4878 Evaluating oedema
• CPC Class Codes: A61N 1/37 Monitoring; Protecting

Abstract

A method of determining an impedance of at least one lung of a patient having an implanted pacemaker that comprises first and second leads and a case, the method comprising:

• • a) using the leads and the case to acquire at least a first and a second impedance measurement responsive to impedance of the patient'"'"'s chest that are at least partially independent; and
  • b) using the impedance measurements to determine the impedance of at least one of the lungs substantially independently of impedance of the other lung.

Claims

1. A method of determining a specific impedance of tissue of at least one of two lungs of a patient having an implanted pacemaker that comprises first and second leads and a case, the method comprising:

a) using the first and second leads and the case to acquire at least a first and a second impedance measurement responsive to impedance of the patient'"'"'s chest, said first and second impedance measurements being at least partially independent; and

b) determining the specific impedance of tissue of at least a first one of the patient'"'"'s lungs substantially independently of specific impedance of tissue of the second one of the patient'"'"'s lungs, such that Poisson'"'"'s equation for a model of the chest has a solution consistent with the at least two impedance measurements.

2. A method according to claim 1, wherein the model of the chest treats the specific impedances of tissue of the two lungs as two independent variables.

3. A method according to claim 1, wherein, for each impedance measurement, a different configuration of the first and second leads is used than is used for any other of the impedance measurements, for generating current or for measuring voltage or for both.

4. A method according to claim 3, wherein, for the first and second impedance measurements, the current is generated only between the case and one of the leads, the same lead for both the first and second impedance measurements, and the voltage involves only a potential difference between the case and one of the leads, a different one for the first impedance measurement than for the second impedance measurement.

5. A method according to claim 1, wherein determining the specific impedance of tissue of at least one lung comprises determining the specific impedances of tissue of both lungs.

6. A method according to claim 5, wherein the impedance measurements also comprise a third impedance measurement.

7. A method according to claim 6, also including determining a third parameter of the patient'"'"'s thorax, in addition to the two specific impedances of tissue of the lungs.

8. A method according to claim 7, wherein the third parameter comprises an intravascular volume of the patient'"'"'s thorax.

9. A method according to claim 6, wherein a least squares method is used to find a fit of the two specific impedances of tissue of the lungs to the at least three impedance measurements.

10. A method according to claim 5, wherein determining the specific impedances of tissue of the lungs comprises:

a) making an initial guess for values of the specific impedances;

b) calculating expected impedance measurements for said values of the specific impedances;

c) correcting values of the specific impedances according to a difference between measured and expected values for the impedance measurements; and

d) repeating (b) and (c) until a convergence criterion is satisfied.

11. A method according to claim 10, wherein calculating expected impedance measurements comprises using one or more of a finite element method, a finite difference method, a finite boundary element method, and a finite volume method.

12. A method according to claim 1, wherein determining the specific impedance of tissue of at least one lung comprises determining the specific impedance of tissue of the lung responsive to a solution of equations that satisfy constraints defined by the first and second impedance measurements, for a model of the chest with two specific impedances of lung tissue as unknowns.

13. A method according to claim 1, wherein the case is implanted on a side of the patient'"'"'s chest opposite to the side of the first lung.

14. A method according to claim 1, wherein one of the leads is implanted in a right ventricle of the patient.

15. A method according to claim 1, wherein one of the leads is implanted in a right atrium of the patient.

16. A method according to claim 1, wherein one of the leads is implanted in a left ventricle coronary vein of the patient.

17. A method according to claim 1, wherein the case is implanted in a left pre-pectoral position.

18. A method according to claim 1, wherein the case is implanted in a right pre-pectoral position.

19. A method of determining a specific impedance of tissue of at least one lung in a chest of a patient, comprising:

a) generating one or more currents, each between a pacemaker case implanted in the chest, and at least one of a first lead and a second lead implanted at different locations in a heart of the patient;

b) measuring one or more voltages, each involving a potential difference between at least one of the first and second leads and the case, including at least a first voltage due at least in part to at least a portion of the current which is generated between the other one of the first and second leads and the case; and

c) calculating the specific impedance of tissue of at least one lung only from the one or more currents and the one or more voltages, including at least the first voltage.

20. A pacemaker for bio-impedance measurements, comprising:

a) a case adapted for implanting in the chest;

b) a first lead adapted for implanting at a location in the heart;

c) a second lead adapted for implanting at a different location in the heart;

d) a bio-impedance system, adapted to make impedance measurements comprising at least a first and a second impedance measurement, using voltage differences between the case and the first and second leads; and

e) a data analyzer, adapted to determine a specific impedance of tissue of at least a first one of the lungs, substantially independently of specific impedance of tissue of the other lung, such that Poisson'"'"'s equation for a model of the chest has a solution consistent with the at least two impedance measurements.

21. A method of determining specific impedances of tissue of at least three portions of two lungs of a patient having an implanted pacemaker that comprises first and second leads and a case, the method comprising:

a) using the first and second leads and the case to acquire at least a first, a second and a third impedance measurement responsive to impedance of the patient'"'"'s chest that are at least partially independent; and

b) using the impedance measurements to determine the specific impedance of tissue of at least three portions of the lungs of the patient, including at least one portion of one of the patient'"'"'s lungs, and at least two portions of the other one of the patient'"'"'s lungs, substantially independently of each other.