Cardiac pacing response classification using an adaptable classification interval

• US 7,908,006 B2
• Filed: 12/15/2004
• Issued: 03/15/2011
• Est. Priority Date: 12/15/2004
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Zhang, Geng
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): STOKLOSA, JOSEPH A
• Application Number:
  US11/012,443
• Publication Number:
  US 20060129194A1
• Time in Patent Office: 2,281 Days
• Field of Search: 607 28- 29, 607/9
• US Class Current: 607/28
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold

Abstract

Methods and systems involve the formation of a classification interval used for sensing a cardiac signal following a pacing pulse to determine a cardiac response to pacing. One or more cardiac signals associated with a type of cardiac pacing response are sensed. The timing of at least one feature of the cardiac signal may be used to define an initial cardiac response classification interval. The classification interval is adapted based on the variability of the timing of the feature. The classification interval may be adapted using a predetermined number of additional cardiac signals or until a predetermined stability criterion is achieved.

Claims

1. A method of operating a cardiac medical device to automatically form a cardiac response classification interval during which a cardiac signal is sensed to determine a cardiac response of a heart to pacing, the method comprising:

sensing one or more cardiac signals associated with a type of cardiac pacing response;

determining timing variability of one or more features of the cardiac signals;

forming the cardiac response classification interval including temporally orienting the classification interval with respect to timing of the one or more cardiac signal features, and setting a duration of the classification interval using the timing variability of the one or more cardiac signal features;

determining the cardiac response to pacing using the classification interval;

delivering pacing therapy to the heart based on determination of the cardiac pacing response; and

determining whether a predetermined stability criterion has been achieved based on the variability of a parameter of the cardiac response classification interval being below a predetermined value;

wherein forming the cardiac response classification interval comprises adapting an upper or lower bound of the classification interval until the predetermined stability criterion is determined to be achieved.

2. The method of claim 1, wherein the one or more features comprises a peak amplitude.

3. The method of claim 1, wherein the type of cardiac pacing response comprises a captured response.

4. The method of claim 1, wherein determining the timing variability comprises determining a standard deviation.

5. The method of claim 1, further comprising adapting the cardiac response classification interval using one or more additional cardiac signals.

6. The method of claim 1, wherein forming the cardiac response classification interval comprises:

determining values for the timing of a particular feature for each of the cardiac signals;

averaging the particular feature timing values;

determining a standard deviation of the particular feature timing values;

using the average feature timing value as a central point;

defining a timing interval around the central point using the standard deviation; and

forming the cardiac response classification interval based on the timing interval.

7. The method of claim 1, further comprising using the classification interval to determine a captured response to a pacing pulse.

8. The method of claim 1, further comprising using the classification interval to discriminate between a captured or non-captured response and a fusion beat.

9. The method of claim 1, wherein forming the cardiac response classification interval comprises adapting the upper or lower bound of the classification interval based on a predetermined number of cardiac beats.

18. The method of claim 1, further comprising determining peak amplitude and peak time of a cardiac signal associated with delivery of a pacing pulse, wherein determining the cardiac response to pacing using the classification interval comprises discriminating between capture, non-captured, and fusion responses to the pacing pulse, wherein:

the response is indicated as fusion if the peak time is not within the classification interval;

the response is indicated as non-capture if the peak time is within the classification interval and the peak amplitude is below a threshold; and

the response is indicated as capture if the peak time is within the classification interval and the peak amplitude is above the threshold.

10. A medical system, comprising:

a pacing circuit configured to deliver pacing pulses to a heart chamber;

a sensing circuit configured to sense cardiac signals associated with the pacing pulses;

a processor coupled to the sensing circuit, the processor configured to determine a cardiac response classification interval defining a period of time after a pacing pulse that a cardiac signal is sensed to determine a response to the pacing pulse, the processor configured to temporally orient the classification interval with respect to timing of at least one cardiac signal feature, and to determine a duration of the classification interval based on a timing variability of the at least one cardiac signal feature, the cardiac signal feature associated with a type of cardiac pacing response; and

cardiac response classification circuitry configured to determine a cardiac response to pacing using the classification interval, wherein the pacing circuit is configured to deliver pacing therapy based at least in part on determination of the cardiac pacing response;

wherein the processor is further configured to determine the variability of a parameter of the cardiac response classification interval, determine whether a predetermined stability criterion has been achieved based on the variability of the parameter of the cardiac response classification interval being below a predetermined value, and adapt the cardiac response classification interval until the stability criterion is determined to be achieved.

11. The system of claim 10, wherein the feature comprises a peak amplitude.

12. The system of claim 10, wherein the type of cardiac pacing response comprises a captured response.

13. The system of claim 10, wherein the processor is configured to determine the standard deviation of the feature timing.

14. The system of claim 10, wherein the processor is configured to determine values for the timing of the feature for each of the cardiac signals, average the feature timing values, determine a standard deviation of the feature timing values, and form the cardiac response classification interval based on the average feature timing and the standard deviation.

19. The system of claim 10, wherein the cardiac response classification circuitry is configured to determine peak amplitude and peak time of a cardiac signal that is associated with delivery of a pacing pulse and to determine the cardiac response using the classification interval by discriminating between capture, non-captured, and fusion responses to the pacing pulse, wherein:

the response is indicated as fusion if the peak time is not within the classification interval;

the response is indicated as non-capture if the peak time is within the classification interval and the peak amplitude is below a threshold; and

the response is indicated as capture if the peak time is within the classification interval and the peak amplitude is above the threshold.

15. A system for forming a cardiac response classification interval used for sensing a cardiac signal following a pacing pulse to determine a response to the pacing pulse, comprising:

means for sensing cardiac signals associated with a type of cardiac pacing response;

means for determining a variability of a timing of one or more features of the cardiac signals;

means for forming the cardiac response classification interval including temporally orienting the classification interval with respect to the timing of the one or more features, and setting a duration of the classification interval using the timing variability;

means for determining a cardiac pacing response using the cardiac response classification interval;

pacing circuitry configured to deliver pacing therapy based at least in part on determination of the cardiac pacing response; and

means for determining whether a predetermined stability criterion has been achieved based on comparison of a predetermined value to the variability of a parameter of the cardiac response classification interval;

wherein the forming means also adapts an upper or lower bound of the classification interval until the predetermined stability criterion is determined to be achieved.

16. The system of claim 15, wherein the means for forming the cardiac response classification interval is configured to modify the cardiac response classification interval using one or more additional cardiac signals sensed during delivery of a pacing therapy.

17. The system of claim 15, wherein the means for determining the cardiac pacing response is configured to detect capture using the cardiac response classification interval.