Methods and systems to monitor venous blood oxygen saturation

• US 7,909,764 B1
• Filed: 11/30/2007
• Issued: 03/22/2011
• Est. Priority Date: 11/30/2007
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Qu, Fujian, Wenzel, Brian Jeffrey, Farazi, Taraneh Ghaffari
• Primary Examiner(s): Le; Long V
• Assistant Examiner(s): Rozanski; Michael T
• Application Number:
  US11/948,381
• Time in Patent Office: 1,208 Days
• Field of Search: 600/309, 600/509, 600/510, 600/515, 600/607
• US Class Current: 600/309
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/355 Detecting T-waves
• CPC Class Codes: A61B 5/36 Detecting PQ interval, PR interval or QT interval
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood

Abstract

Methods and system are provided for monitoring a patients venous blood oxygen saturation (SvO2). At least one signal indicative of electrical activity of a patient'"'"'s heart is obtained. Such a signal can be, e.g., an IEGM or ECG signal. In specific embodiments, such a signal(s) can be obtained from implanted electrodes, and thus, embodiments of the present invention can be implemented by an implantable system. Additionally, there are measurements of at least one metric of cardiac cycles represented in the at least one signal indicative of electrical activity of the patient'"'"'s heart, where the metric changes with changes in SvO2. Examples of such metric include T-wave metrics and PR intervals. SvO2, and changes therein, are monitored based on the measured metric(s).

Claims

1. A method for monitoring a patient'"'"'s venous blood oxygen saturation (SvO2), comprising:

(a) obtaining at least one signal indicative of electrical activity of a patient'"'"'s heart;

(b) measuring at least one metric of cardiac cycles represented in the at least one signal indicative of electrical activity of the patient'"'"'s heart, wherein the at least one metric changes with changes in SvO2; and

(c) monitoring the patient'"'"'s SvO2 based on the at least one metric.

2. The method of claim 1, wherein step (c) includes normalizing the at least metric before the patient'"'"'s SvO2 is monitored based on the at least one metric.

3. The method of claim 1, wherein step (a) includes obtaining at least one intracardiac electrogram (IEGM) and/or at least one electrocardiogram (ECG).

4. The method of claim 1, further comprising:

(d) monitoring changes in the patient'"'"'s SvO2 as steps (a), (b) and (c) are repeated over time.

5. The method of claim 1, wherein:

step (b) comprises measuring at least one T-wave metric of cardiac cycles represented in the at least one signal indicative of electrical activity of the patient'"'"'s heart; and

step (c) comprises monitoring the patient'"'"'s SvO2 based on the at least one T-wave metric.

6. The method of claim 5, wherein step (b) includes measuring at least one of the following T-wave metrics of cardiac cycles:

T-wave amplitude maximum;

T-wave amplitude minimum;

T-wave amplitude peak-to-peak;

T-wave amplitude dispersion;

T-wave centroid;

QT interval;

T-wave area;

T-wave frequency content; and

T-wave frequency spread.

7. The method of claim 5, further comprising:

(d) monitoring changes in the patient'"'"'s SvO2 as steps (a), (b) and (c) are repeated over time;

wherein increases in the at least one T-wave metric are interpreted as increases in the patient'"'"'s SvO2; and

wherein decreases in the at least one T-wave metric are interpreted as decreases in the patient'"'"'s SvO2.

8. The method of claim 7, further comprising:

(e) monitoring changes in the patient'"'"'s heart failure condition based on changes in the patient'"'"'s SvO2 as monitored based on changes in the at least one T-wave metric;

wherein decreases in the patient'"'"'s SvO2 over time are interpreted as being indicative of worsening of the patient'"'"'s heart failure; and

wherein increases in the patient'"'"'s SvO2 over time are interpreted as being indicative of improvement of the patient'"'"'s heart failure.

9. The method of claim 7, further comprising:

(e) adjusting a pacing rate based on changes in the patient'"'"'s SvO2 as monitored based on changes in the at least one T-wave metric.

10. The method of claim 7, further comprising:

(e) adjusting at least one pacing interval based on changes in the patient'"'"'s SvO2 as monitored based on changes in the at least one T-wave metric.

11. The method of claim 7, further comprising:

(e) monitoring for anemic episodes based on changes in the patient'"'"'s SvO2 as monitored based on changes in the at least one T-wave metric;

wherein transient decreases in the patient'"'"'s SvO2 are interpreted as being indicative of anemic episodes.

12. The method of claim 7, further comprising:

(e) monitoring for internal hemorrhaging based on changes in the patient'"'"'s SvO2 as monitored based on changes in the at least one T-wave metric;

wherein transient decreases in the patient'"'"'s SvO2 are interpreted as being indicative of internal hemorrhaging.

13. The method of claim 7, further comprising:

(e) monitoring for episodes of sleep apnea based on changes in the patient'"'"'s SvO2 as monitored based on changes in the at least one T-wave metric;

wherein transient decreases in the patient'"'"'s SvO2, while the patient is likely sleeping, are interpreted as being indicative of episodes of sleep apnea.

14. The method of claim 1, wherein:

step (b) comprises measuring PR intervals of cardiac cycles represented in the at least one signal indicative of electrical activity of the patient'"'"'s heart; and

step (c) comprises monitoring the patient'"'"'s SvO2 based on the PR intervals.

15. The method of claim 14, further comprising:

(d) monitoring changes in the patient'"'"'s SvO2 as steps (a), (b) and (c) are repeated over time;

wherein increases in the PR intervals are interpreted as increases in the patient'"'"'s SvO2; and

wherein decreases in the PR intervals are interpreted as decreases in the patient'"'"'s SvO2.

16. The method of claim 15, further comprising performing at least one of the following based on changes in the patient'"'"'s SvO2 as monitored based on changes in PR intervals:

(e.1) monitoring changes in the patient'"'"'s heart failure condition based on changes in the patient'"'"'s SvO2 as monitored based on changes in PR intervals, wherein decreases in the patient'"'"'s SvO2 over time are interpreted as being indicative of worsening of the patient'"'"'s heart failure, and increases in the patient'"'"'s SvO2 over time are interpreted as being indicative of improvement of the patient'"'"'s heart failure;

(e.2) adjusting a pacing rate based on changes in the patient'"'"'s SvO2 as monitored based on changes in PR intervals;

(e.3) adjusting at least one pacing interval based on changes in the patient'"'"'s SvO2 as monitored based on changes in PR intervals;

(e.4) monitoring for anemic episodes based on changes in the patient'"'"'s SvO2 as monitored based on changes PR intervals, wherein transient decreases in the patient'"'"'s SvO2 are interpreted as being indicative of anemic episodes;

(e.5) monitoring for internal hemorrhaging based on changes in the patient'"'"'s SvO2 as monitored based on changes in PR intervals, wherein transient decreases in the patient'"'"'s SvO2 are interpreted as being indicative of internal hemorrhaging; and

(e.5) monitoring for episodes of sleep apnea based on changes in the patient'"'"'s SvO2 as monitored based on changes in PR intervals, wherein transient decreases in the patient'"'"'s SvO2, while the patient is likely sleeping, are interpreted as being indicative of episodes of sleep apnea.

17. A method for monitoring for changes in a patient'"'"'s venous blood oxygen saturation (SvO2), comprising:

(a) obtaining at least one signal indicative of electrical activity of a patient'"'"'s heart;

(b) measuring at least one metric of cardiac cycles represented in the at least one signal indicative of electrical activity of the patient'"'"'s heart, wherein the at least one metric changes with changes in SvO2;

(c) repeating steps (a) and (b) over time to thereby monitor changes over time in the at least one metric; and

(d) monitoring changes in the patient'"'"'s SvO2 based on the changes in the at least one metric.

18. The method of claim 17, wherein step (c) includes normalizing the at least one metric before changes in the at least one metric are monitored.

19. A system for monitoring a patient'"'"'s venous blood oxygen saturation (SvO2), comprising:

a sensing circuit to obtain at least one signal indicative of electrical activity of a patient'"'"'s heart;

a measure component to measure at least one metric of cardiac cycles represented in the at least one signal indicative of electrical activity of the patient'"'"'s heart, wherein the at least one metric changes with changes in SvO2; and

a monitor to monitor the patient'"'"'s SvO2 based on the at least one metric.

20. The system of claim 19, wherein the system comprises an implantable system.

21. The system of claim 19, wherein the monitor monitors changes in the patient'"'"'s SvO2 based on the changes in the at least one metric.

22. The system of claim 19, wherein the at least one metric comprises at least one of a T-wave metric and a PR interval.

23. The system of claim 19, wherein the measure component and the monitor are implemented by a microcontroller of an implantable device.

24. The system of claim 19, wherein the monitor normalizes that at least one metric before the monitor monitors the patient'"'"'s SvO2 based on the at least one metric.