Expandable medical device for delivery of beneficial agent

• US 7,909,865 B2
• Filed: 04/17/2009
• Issued: 03/22/2011
• Est. Priority Date: 03/30/1998
• Status: Expired due to Fees

• Current Assignee: Conor Medsystems Incorporated
• Original Assignee: Conor Medsystems Incorporated
• Inventors: Shanley, John F.
• Primary Examiner(s): Willse; David H
• Assistant Examiner(s): Blanco; Javier G
• Application Number:
  US12/425,772
• Publication Number:
  US 20090276034A1
• Time in Patent Office: 704 Days
• Field of Search: 623/1.42
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91541 Adjacent bands are arranged out of phase
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir

Abstract

An expandable medical device having a plurality of elongated struts, the plurality of elongated struts being joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter, and the plurality of struts each having a strut width in a circumferential direction. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of the strut. A beneficial agent may be loaded into the opening within the strut. The expandable medical device may further include a plurality of ductile hinges formed between the elongated struts, the ductile hinges allowing the cylindrical device to be expanded or compressed from the first diameter to the second diameter by deformation of the ductile hinges.

Claims

1. An expandable medical device comprising:

at least two cylindrical tubes connected by S-shaped bridging elements, each of said cylindrical tubes comprising a network of elongated and substantially rigid struts, each elongated and substantially rigid strut having a neutral axis along opposite ends, and inner and outer surfaces defining a thickness;

a plurality of through-openings in the elongated and substantially rigid struts, said plurality of openings extending through said thickness at intervals along the neutral axis;

a plurality of ductile hinges interconnecting said elongated and substantially rigid struts, each of said ductile hinges having a reduced section formed at either end of the elongated and substantially rigid strut permitting the expandable medical device to radially expand or compress from a first diameter to a second diameter by first elastically and then plastically deforming, wherein the elongated and substantially rigid struts experience substantially no plastic deformation during expansion or compression from the first diameter to the second diameter;

at least one beneficial agent contained primarily within the through-openings, said beneficial agent provided in a plurality of layers,

wherein a width of the ductile hinge is defined as the dimension in the direction perpendicular to a length of the ductile hinge, a thickness of the ductile hinge is defined as the dimension in the radial direction of the device, and the reduced section has a portion of constant width, wherein the inner and outer surfaces of the struts are substantially without beneficial agent thereon, and wherein the ductile hinges are devoid of any openings.

2. The device according to claim 1, wherein the through-openings are formed by laser drilling.

3. The device according to claim 1, wherein the beneficial agent includes at least one antiproliferative.

4. The device according to claim 1, wherein the beneficial agent is paclitaxel.

5. The device according to claim 1, wherein the beneficial agent is a rapamycin.

6. The device according to claim 1, wherein a transition from the elongated strut to the reduced section of the hinge is abrupt.

7. The device according to claim 1, wherein the beneficial agent includes antithrombins.