Load bearing biocompatible device
First Claim
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1. A hydrogel having a surface, comprising:
- a microarchitecture that determines cell response, said microarchitecture comprising superficial pores located on or near the surface of the hydrogel;
wherein said superficial pores do not extend throughout an entire depth of said hydrogel;
wherein said superficial pores enhance osteoblast differentiation and permit proliferation of osteoblasts;
wherein said hydrogel is load-bearing; and
wherein said hydrogel comprises at least one bioactive agent.
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Abstract
Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis.
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Citations
14 Claims
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1. A hydrogel having a surface, comprising:
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a microarchitecture that determines cell response, said microarchitecture comprising superficial pores located on or near the surface of the hydrogel; wherein said superficial pores do not extend throughout an entire depth of said hydrogel; wherein said superficial pores enhance osteoblast differentiation and permit proliferation of osteoblasts; wherein said hydrogel is load-bearing; and wherein said hydrogel comprises at least one bioactive agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A hydrogel comprising:
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a hydrogel surface having a plurality of superficial pores thereon; wherein said superficial pores are located at or near said hydrogel surface; wherein said superficial pores do not extend throughout said hydrogel; wherein the hydrogel is configured for implantation into a joint; wherein said hydrogel comprises at least one bioactive agent; wherein the superficial pores have an average cross-section of between about 1 and 100 micrometers; and wherein the pores are within about 1 millimeter of the hydrogel surface. - View Dependent Claims (13, 14)
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Specification