Hybrid device for cell therapies
First Claim
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1. A device for receiving implanted biological material and configured for implantation into a patient, wherein said device comprises:
- a) a porous outer wall defining an inner space, said inner space providing a receptacle for implanted biological material comprising a selected tissue/cell product, said inner space sized to receive 6,000 to 12,000 cells per kilogram of the weight of the patient, and said outer wall having a porosity which permits vasculature to reach the implanted biological material from outside the porous outer wall;
b) a fluid manifold assembly for selectively infusing at least one of immunosuppressive and/or growth factor media to said inner space, wherein said manifold assembly includes at least one longitudinally disposed media distribution conduit for distributing media to said inner space, and wherein microperforations along the length of said conduit compensate for a decrease in pressure along the length of the conduit in a direction away from the manifold for substantially uniform infusion and distribution of the media within said inner space; and
c) a pump or a reservoir for such media, operatively coupled to said manifold assembly.
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Abstract
A device for receiving implanted biological material includes a porous outer wall defining an inner space, a fluid manifold assembly for selectively infusing at least one of immunosuppressive and growth factor media to said space, and a pump structure operatively coupled to the manifold assembly. The device may comprise an additional plunger body for being disposed in said space and so as to define a peripheral gap between the plunger and the perforated wall of the device.
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Citations
36 Claims
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1. A device for receiving implanted biological material and configured for implantation into a patient, wherein said device comprises:
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a) a porous outer wall defining an inner space, said inner space providing a receptacle for implanted biological material comprising a selected tissue/cell product, said inner space sized to receive 6,000 to 12,000 cells per kilogram of the weight of the patient, and said outer wall having a porosity which permits vasculature to reach the implanted biological material from outside the porous outer wall; b) a fluid manifold assembly for selectively infusing at least one of immunosuppressive and/or growth factor media to said inner space, wherein said manifold assembly includes at least one longitudinally disposed media distribution conduit for distributing media to said inner space, and wherein microperforations along the length of said conduit compensate for a decrease in pressure along the length of the conduit in a direction away from the manifold for substantially uniform infusion and distribution of the media within said inner space; and c) a pump or a reservoir for such media, operatively coupled to said manifold assembly. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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15. A method for implanting biological material in a patient, comprising:
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a) providing a device for receiving biological material, said device comprising; i) a porous outer wall defining an inner space, said inner space providing a receptacle for implanted biological material comprising a selected tissue/cell product, said inner space sized to receive 6,000 to 12,000 cells per kilogram of the weight of the patient, and said outer wall having a porosity which permits vasculature to reach the implanted biological material from outside the porous outer wall; ii) a fluid manifold assembly for selectively infusing at least one of immunosuppressive and/or growth factor media to said inner space, wherein said manifold assembly includes at least one longitudinally disposed media distribution conduit for distributing media to said inner space, and wherein microperforations along the length of said conduit compensate for a decrease in pressure along the length of the conduit in a direction away from the manifold for substantially uniform infusion and distribution of the media within said inner space; and iii) a pump or a reservoir for such media, operatively coupled to said manifold assembly; b) implanting said device at a selected location within the patient; c) allowing tissue ingrowth through said porous outer wall into said inner space; d) disposing the biological material comprising a selected tissue/cell product within said inner space; and e) selectively infusing at least one of immunosuppressive and/or growth factor media to said inner space. - View Dependent Claims (16, 17, 18, 19)
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20. A method for implanting biological factor producing biological material in a patient, comprising:
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a) providing a device for receiving biological factor producing biological material, said device comprising; i) a porous outer wall defining an inner space, said inner space providing a receptacle for implanted biological material comprising a selected tissue/cell product, said inner space sized to receive 6,000 to 12,000 cells per kilogram of the weight of the patient, and said outer wall having a porosity which permits vasculature to reach the implanted biological material from outside the porous outer wall; ii) a fluid manifold assembly for selectively infusing at least one of immunosuppressive and/or growth factor media to said inner space, wherein said manifold assembly includes at least one longitudinally disposed media distribution conduit for distributing media to said inner space, and wherein microperforations along the length of said conduit compensate for a decrease in pressure along the length of the conduit in a direction away from the manifold for substantially uniform infusion and distribution of the media within said inner space; iii) a pump or a reservoir for such media, operatively coupled to said assembly; and iv) a structure defining a path for the biological factor produced by said biological material to be conducted to the patient'"'"'s circulatory system; b) implanting said device at a selected location within the patient; c) disposing the biological factor producing biological material comprising a selected tissue/cell product within said inner space; and d) selectively infusing at least one of immunosuppressive and/or growth factor media to said inner space using said assembly. - View Dependent Claims (21, 22, 23, 24)
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Specification