Device and methods for liquid crystal-based bioagent detection
First Claim
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1. A liquid crystal device for detecting the presence of a bioagent in a sample, comprising:
- (a) a liquid crystal;
(b) an aqueous phase positioned such that an interface exists between the liquid crystal and said aqueous phase; and
(c) a membrane located at the interface containing a polymerized target of a bioagent, said polymerized target comprising a target of the bioagent covalently cross-linked to a polymer network, wherein interaction of said bioagent with the polymerized target causes an orientation change in said liquid crystal thereby indicating the presence of the bioagent in the sample.
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Abstract
The present invention provides liquid crystal-based devices and methods for bioagent detection. In certain aspects, the present invention is directed to devices and methods utilizing liquid crystals and membranes containing polymerized targets that can report the presence of bioagents including, but not limited to, enzymes, antibodies, and toxins.
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Citations
10 Claims
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1. A liquid crystal device for detecting the presence of a bioagent in a sample, comprising:
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(a) a liquid crystal; (b) an aqueous phase positioned such that an interface exists between the liquid crystal and said aqueous phase; and (c) a membrane located at the interface containing a polymerized target of a bioagent, said polymerized target comprising a target of the bioagent covalently cross-linked to a polymer network, wherein interaction of said bioagent with the polymerized target causes an orientation change in said liquid crystal thereby indicating the presence of the bioagent in the sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A liquid crystal device for detecting the presence of a bioagent in a sample, comprising:
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(a) a liquid crystal; (b) an aqueous phase positioned such that an interface exists between the liquid crystal and said aqueous phase; and (c) a polymerized membrane comprising a polymer cross-linked to a target of a bioagent, said polymerized membrane located at the interface between the liquid crystal and said aqueous phase wherein interaction of said bioagent with the target causes an orientation change in said liquid crystal thereby indicating the presence of the bioagent in the sample.
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Specification