Copolymers having 1-methyl-2-methoxyethyl moieties

• US 7,910,678 B2
• Filed: 11/19/2007
• Issued: 03/22/2011
• Est. Priority Date: 11/21/2006
• Status: Active Grant

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Pacetti, Stephen
• Primary Examiner(s): Wu; David
• Assistant Examiner(s): NGUYEN, VU ANH
• Application Number:
  US11/942,700
• Publication Number:
  US 20080125560A1
• Time in Patent Office: 1,219 Days
• Field of Search: 526/319, 526/320, 526/328, 526/329.6
• US Class Current: 526/329.6
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: C08L 27/18 Homopolymers or copolymers or tetrafluoroethene

Abstract

Copolymers including a hydrophobic monomer and an acryloyl or methacryloyl ester of propylene glycol monomethyl ether, also referred to as 1-methyl-2-methoxyethyl acrylate (“MMOEA”) are provided. The combination of the hydrophobic monomer and the MMOEA monomer advantageously provides desired mechanical strength, biocompatibility, and drug permeability in the copolymers. The copolymers can advantageously be used on medical devices.

Claims

1. A biocompatible polymer comprising:

2. A biocompatible polymer as in claim 1, in which R₁ is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, 2-ethyl-hexyl, n-hexyl, cyclohexyl, n-hexyl, isobornyl, trimethylcyclohexyl and combination thereof.

3. A biocompatible polymer as in claim 1, in which the glass transition temperature of the polymer when hydrated is in a range from about −

30°

C. to about 37°

C.

4. A biocompatible polymer as in claim 1, in which the glass transition temperature of the polymer when hydrated is in a range from about 0°

C. to about 37°

C.

5. A biocompatible polymer as in claim 1, in which the glass transition temperature of the polymer when dry is in a range from about −

30°

C. to about 100°

C.

6. A biocompatible polymer as in claim 1, in which the glass transition temperature of the polymer when dry is in a range from about 0°

C. to about 70°

C.

7. A biocompatible polymer as in claim 1 having a chemical formula of

8. A biocompatible polymer as in claim 1, having a chemical formula of,

9. A biocompatible polymer as in claim 1, in which the number average molecular weight is in a range from about 20K to about 800K.

10. A biocompatible polymer as in claim 1, in which the number average molecular weight is in a range from about 100K to about 600K.

11. A biocompatible polymer as in claim 1, in which the number average molecular weight is in a range from about 2K to about 200K.

12. An implant device coating comprising the biocompatible polymer of any one of claims 1 to 11.

13. A medical device comprising a supporting structure having a coating associated therewith, the coating comprising a polymer having the formula,

14. A medical device as in claim 13, in which R₁ is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, 2-ethyl hexyl, n-hexyl, cyclohexyl, n-hexyl, isobornyl, trimethylcyclohexyl and combination thereof.