Self-assembled heterogeneous integrated optical analysis system

• US 7,910,934 B2
• Filed: 07/02/2009
• Issued: 03/22/2011
• Est. Priority Date: 01/05/2007
• Status: Expired due to Fees

• Current Assignee: Washington University In St Louis
• Original Assignee: University of Washington
• Inventors: Meldrum, Deirdre, Amirparviz, Babak, Saeedi, Ehsan, Kim, Samuel
• Primary Examiner(s): Smith; Zandra
• Assistant Examiner(s): Green; Telly D
• Application Number:
  US12/497,518
• Publication Number:
  US 20100096640A1
• Time in Patent Office: 628 Days
• Field of Search: 257 80- 82, 257/84, 257/88, 438/26, 438/116
• US Class Current: 257/82
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: G01N 21/253 for batch operation, i.e. multisample apparatus analytical automats G01N35/00
• CPC Class Codes: G01N 21/6454 using an integrated detector array
• CPC Class Codes: H01L 2224/95101 in a liquid medium
• CPC Class Codes: H01L 24/95 at chip-level, i.e. with connecting carried out on a plurality of singulated devices, i.e. on diced chips
• CPC Class Codes: H01L 25/042 the devices being arranged next to each other solar cells H01L31/042
• CPC Class Codes: H01L 25/167 comprising optoelectronic devices, e.g. LED, photodiodes
• CPC Class Codes: H01L 2924/00 Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
• CPC Class Codes: H01L 2924/09701 Low temperature co-fired ceramic [LTCC]
• CPC Class Codes: H01L 2924/12041 LED
• CPC Class Codes: H01L 2924/12043 Photo diode
• CPC Class Codes: H01L 31/18 Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof

Abstract

Optical analysis system fluidically self-assembled using shape-coded freestanding optoelectronic components and a template having shape-coded recessed binding sites connected by an embedded interconnect network. Also includes methods of manufacture and use for optical analyses.

Claims

1. A device for optical analysis, comprising:

a template having a plurality of first recessed binding sites with a first shape and a plurality of second recessed binding sites with a second shape, the template having an embedded interconnect network interconnecting the first and second recessed binding sites, wherein each of the first and second recessed binding sites contains an attachment means;

a plurality of light-emitting components having the first shape and at least two electrodes, received into at least some of the first recessed binding sites and electrically connected to the embedded interconnect network by the attachment means; and

a plurality of light-detecting components having the second shape and at least two electrodes, received into at least some of the second recessed binding sites and electrically connected to the embedded interconnect network by the attachment means.

2. The device of claim 1, further comprising a channel adapted to receive a fluid, wherein at least some of the light-emitting components and at least some of the light-detecting components are in optical communication with the channel.

3. The device of claim 1, wherein the attachment means is a solder.

4. The device of claim 1, wherein the light-emitting component electrodes are formed on only one side of the light-emitting components and comprise a circular electrode substantially centered on the light-emitting component and an annular electrode disposed around the circular electrode.

5. The device of claim 1, wherein the light-emitting components are selected from the group consisting of light-emitting diodes, semiconductor lasers, and vertical-cavity surface-emitting lasers.

6. The device of claim 1, wherein the first shape is selected from the group consisting of circular, square, rectangular, triangular, and cruciform.

7. The device of claim 1, wherein the plurality of light-emitting components comprise a first plurality of light-emitting components having a first emission spectrum and a second plurality of light-emitting components having a second emission spectrum, wherein the first emission spectrum and the second emission spectrum are different.

8. The device of claim 1, wherein the plurality of light-detecting components comprise a first plurality of light-sensing components having a first absorption spectrum and a second plurality of light-sensing components having a second absorption spectrum, wherein the first absorption spectrum and the second absorption spectrum are different.

9. The device of claim 1, wherein the light-emitting components and the light-detecting components comprise components in a fluorescence analysis system.

10. A device for optical analysis, comprising:

a first template having a plurality of first recessed binding sites with a first shape, the first template having a first embedded interconnect network interconnecting the first recessed binding sites, wherein each of the first recessed binding sites contains an attachment means;

a plurality of light-emitting components having the first shape and at least two electrodes, received into at least some of the first recessed binding sites and electrically connected to the first embedded interconnect network by the attachment means;

a second template having a plurality of second recessed binding sites with a second shape, the second template having a second embedded interconnect network interconnecting the second recessed binding sites, wherein each of the second recessed binding sites contains an attachment means; and

a plurality of light-detecting components having the second shape and at least two electrodes, received into at least some of the second recessed binding sites and electrically connected to the second embedded interconnect network by the attachment means.

11. The device of claim 10, further comprising a channel adapted to receive a fluid, wherein at least some of the light-emitting components and at least some of the light-detecting components are in optical communication with the channel.

12. The device of claim 10, wherein the attachment means is a solder.

13. The device of claim 10, wherein the light-emitting component electrodes are formed on only one side of the light-emitting components and comprise a circular electrode substantially centered on the light-emitting component and an annular electrode disposed around the circular electrode.

14. The device of claim 10, wherein the first template and the second template comprise a unitary template.

15. The device of claim 10, wherein the first shape and the second shape are different.

16. The device of claim 10, wherein the first embedded interconnect network and the second embedded interconnect network are connected.

17. The device of claim 10, wherein the light-emitting components are selected from the group consisting of light-emitting diodes, semiconductor lasers, and vertical-cavity surface-emitting lasers.

18. The device of claim 10, wherein the first shape is selected from the group consisting of circular, square, rectangular, triangular, and cruciform.

19. The device of claim 10, wherein the plurality of light-emitting components comprise a first plurality of light-emitting components having a first emission spectrum and a second plurality of light-emitting components having a second emission spectrum, wherein the first emission spectrum and the second emission spectrum are different.

20. The device of claim 10, wherein the plurality of light-detecting components comprise a first plurality of light-sensing components having a first absorption spectrum and a second plurality of light-sensing components having a second absorption spectrum, wherein the first absorption spectrum and the second absorption spectrum are different.

21. The device of claim 10, wherein the device comprises a fluorescence analysis system.