Orthovoltage radiotherapy
First Claim
1. A method, of treating a region of an eye of a patient, comprising:
- producing an x-ray beam with a width of from about 0.5 mm to about 6 mm and having a photon energy between about 40 keV and about 250 keV;
directing the x-ray beam, based on a point on an outer surface of the eye, toward the eye region within the eye; and
exposing the region to a dose of from about 1 Gy to about 40 Gy of x-ray radiation.
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Accused Products
Abstract
A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.
253 Citations
27 Claims
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1. A method, of treating a region of an eye of a patient, comprising:
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producing an x-ray beam with a width of from about 0.5 mm to about 6 mm and having a photon energy between about 40 keV and about 250 keV; directing the x-ray beam, based on a point on an outer surface of the eye, toward the eye region within the eye; and exposing the region to a dose of from about 1 Gy to about 40 Gy of x-ray radiation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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- 15. A method, of treating an eye during a treatment period, comprising directing an x-ray radiation beam, based on a point on an outer surface of the eye, from a source outside the eye to a target in or on the retina of the eye, such that a dose of radiation delivered during the treatment period to at least one of the optic nerve and the lens of the eye is no more than about 40 percent of a target dose of radiation delivered to the target.
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18. A method, of treating an eye during a treatment period, comprising directing an x-ray radiation beam, based on a point on an outer surface of the eye, from a source outside an eye to a target in the eye, such that a dose of radiation emitted during the treatment period to eye tissue located about 6 mm from a center of the target is no more than about 40 percent of a target dose of radiation emitted to the target.
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19. A method, of treating inflammation in a patient'"'"'s eye, comprising:
based on data indicative of a location of a region of inflammation in an eye and on a point on an outer surface of the eye, directing at least one x-ray beam from a source outside the eye, through an anterior region of the eye, to the region of inflammation, such that a dose of radiation emitted during a treatment period to eye tissue greater than about 6 mm from a center of the region of inflammation is no more than about 40 percent of the dose of radiation emitted to the region of inflammation. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27)
Specification