Controlled release transdermal drug delivery
First Claim
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1. A device for controlling the release of a substance at a site of interest on a biological membrane comprising:
- means for ablating or altering the biological membrane at the site of interest, wherein said means comprises a mechanical energy delivery system;
means of monitoring permeability state of said membrane at the site of interest;
means of releasing a variable amount of the substance to the site of interest;
said amount varying in response to the status of the monitored permeability state; and
means for housing the device.
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Abstract
Provided herein is a device for controlling the release of a substance at a site of interest in a biological membrane comprising a means of monitoring a physiological state at the site of interest; and a means of releasing a variable amount of the substance to the site of interest where the amount varies in response to the status of the monitored physiological state. Also provided are methods of using the device.
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23 Claims
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1. A device for controlling the release of a substance at a site of interest on a biological membrane comprising:
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means for ablating or altering the biological membrane at the site of interest, wherein said means comprises a mechanical energy delivery system; means of monitoring permeability state of said membrane at the site of interest; means of releasing a variable amount of the substance to the site of interest; said amount varying in response to the status of the monitored permeability state; and means for housing the device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification