Transdermal delivery device
First Claim
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1. A transdermal delivery device, comprising:
- a reservoir containing ingredients and defining a perimeter;
a backing member overlying the reservoir, the backing member being made of a material which is substantially impermeable to the ingredients contained in the reservoir;
a cover for the reservoir, the cover being made of a material substantially impermeable to ingredients contained in the reservoir, but having at least one opening therein defining a perimeter, such that ingredients from the reservoir flow through the opening, but will not readily flow through the material of which the cover is made;
a first seal sealing the cover to the backing member at the perimeter of the reservoir, wherein the first seal which is not subject to permeation, disintegration or degradation by any ingredient contained in the reservoir;
an adhesive layer adhered to the backing member for adhering the device to a patient'"'"'s skin or mucosa, the adhesive layer not extending to the perimeter of the opening in the cover, such that a portion of the cover surrounding said perimeter of the opening is exposed to thereby define a cover sealing surface;
an ingredient containing material layer at least partially adhered to the adhesive layer, wherein the ingredient containing material does not extend to the perimeter of the opening;
a liner covering the sealing surface of the cover and the opening in the cover;
a second seal releasably sealing the liner to the sealing surface of the cover, wherein the second seal is not subject to permeation, disintegration or degradation by any ingredient in the reservoir;
whereby ingredients in the reservoir are sealed therein during storage and non-use by the first and second seals, the cover and liner, but are free to flow through the opening and onto a subject'"'"'s skin or mucosa when the liner is removed from the device and the device is applied to such skin or mucosa.
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Abstract
A dermal, transdermal, mucosal or transmucosal delivery device includes a backing layer overlying an ingredient containing reservoir, and having a microprotrusion array attached thereto, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upon removal of the liner layer, the device may be placed over the desired area of the skin or mucosa and adhesively applied thereto allowing the ingredients to flow from the reservoir through the at least one opening to the skin or mucosa.
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Citations
15 Claims
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1. A transdermal delivery device, comprising:
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a reservoir containing ingredients and defining a perimeter; a backing member overlying the reservoir, the backing member being made of a material which is substantially impermeable to the ingredients contained in the reservoir; a cover for the reservoir, the cover being made of a material substantially impermeable to ingredients contained in the reservoir, but having at least one opening therein defining a perimeter, such that ingredients from the reservoir flow through the opening, but will not readily flow through the material of which the cover is made; a first seal sealing the cover to the backing member at the perimeter of the reservoir, wherein the first seal which is not subject to permeation, disintegration or degradation by any ingredient contained in the reservoir; an adhesive layer adhered to the backing member for adhering the device to a patient'"'"'s skin or mucosa, the adhesive layer not extending to the perimeter of the opening in the cover, such that a portion of the cover surrounding said perimeter of the opening is exposed to thereby define a cover sealing surface; an ingredient containing material layer at least partially adhered to the adhesive layer, wherein the ingredient containing material does not extend to the perimeter of the opening; a liner covering the sealing surface of the cover and the opening in the cover; a second seal releasably sealing the liner to the sealing surface of the cover, wherein the second seal is not subject to permeation, disintegration or degradation by any ingredient in the reservoir;
whereby ingredients in the reservoir are sealed therein during storage and non-use by the first and second seals, the cover and liner, but are free to flow through the opening and onto a subject'"'"'s skin or mucosa when the liner is removed from the device and the device is applied to such skin or mucosa. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification