Method for the treatment of mammalian tissues
First Claim
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1. A method of non-ablative, non-thermal photoactivation of procollagen or photoinhibition of collagenase in the dermis of mammalian skin, comprising the steps of:
- setting an overheating temperature for the mammalian skin to be one of about 2°
C., about 0.5°
C., and about 0.1°
C. over a mammalian skin temperature;
irradiating the dermis with a first pulse having a power density of at least about 10 mW/cm2 and at most about 1000 mW/cm2;
irradiating the dermis with a second pulse;
emitting the first pulse for a duration of about 100 μ
s to 5 ms;
separating the first pulse from the second pulse by an inter-pulse interval of about 10 μ
s to about 10 ms;
emitting a first pulse train; and
separating the first pulse train from a second pulse train by an inter-pulse train interval of about 1 microsecond to about 1 second,wherein each pulse train includes the first pulse and the second pulse, andwherein the inter-pulse train interval is greater than the inter-pulse interval;
whereby irradiating the dermis with the pulse trains causes the photoactivation of procollagen or photoinhibition of collagenase in said dermis of said mammalian skin; and
whereby irradiating the dermis maintains the mammalian skin temperature at or below the overheating temperature.
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Abstract
A method and device for causing a predetermined physiological change in a mammalian tissue. The method includes irradiating the tissue with a radiation having a power density in the tissue substantially larger than an activation threshold power density, the tissue being irradiated under conditions suitable to cause the predetermined physiological change. The device can emit radiation and forms to the anatomy of a patient. The device can both cool the patient and treatment head using one cooling system.
128 Citations
26 Claims
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1. A method of non-ablative, non-thermal photoactivation of procollagen or photoinhibition of collagenase in the dermis of mammalian skin, comprising the steps of:
-
setting an overheating temperature for the mammalian skin to be one of about 2°
C., about 0.5°
C., and about 0.1°
C. over a mammalian skin temperature;irradiating the dermis with a first pulse having a power density of at least about 10 mW/cm2 and at most about 1000 mW/cm2; irradiating the dermis with a second pulse; emitting the first pulse for a duration of about 100 μ
s to 5 ms;separating the first pulse from the second pulse by an inter-pulse interval of about 10 μ
s to about 10 ms;emitting a first pulse train; and separating the first pulse train from a second pulse train by an inter-pulse train interval of about 1 microsecond to about 1 second, wherein each pulse train includes the first pulse and the second pulse, and wherein the inter-pulse train interval is greater than the inter-pulse interval; whereby irradiating the dermis with the pulse trains causes the photoactivation of procollagen or photoinhibition of collagenase in said dermis of said mammalian skin; and whereby irradiating the dermis maintains the mammalian skin temperature at or below the overheating temperature. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification