Silicone adhesive for adhesion to wet surfaces

• US 7,914,645 B2
• Filed: 01/03/2007
• Issued: 03/29/2011
• Est. Priority Date: 01/19/2006
• Status: Expired due to Fees

• Current Assignee: Dow Corning Corporation (Dow, Inc.)
• Original Assignee: Dow Corning Corporation (Dow, Inc.)
• Inventors: Ulman, Katherine Lynn, Raul, Victor Albert, Schalau, Gerald Kenneth II, Thomas, Xavier Jean-Paul, Gantner, David Clayton
• Primary Examiner(s): Gulakowski; Randy
• Assistant Examiner(s): LOEWE, ROBERT S
• Application Number:
  US12/158,718
• Publication Number:
  US 20080295960A1
• Time in Patent Office: 1,546 Days
• Field of Search: 156/329, 424/448, 523/109, 523/120
• US Class Current: 156/329
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61K 9/7069 obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
• CPC Class Codes: A61M 2205/0205 Materials having antiseptic or antimicrobial properties, e.g. silver compounds, rubber with sterilising agent
• CPC Class Codes: A61M 2205/0238 the material being a coating or protective layer
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: C08G 2170/40 Compositions for pressure-sensitive adhesives
• CPC Class Codes: C08L 83/00 Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
• CPC Class Codes: C09J 183/04 Polysiloxanes

Abstract

A silicone adhesive composition used for adhering a device or a substance to a wet surface contains (i) a silicone resin that is cohydrolysis product of a trialkyl hydrolyzable silane and an alkyl silicate in which the cohydrolysis product contains a plurality of silicon-bonded hydroxy groups; (ii) a linear organopolysiloxane fluid containing terminal silicon-bonded hydroxy groups having a viscosity above 200,000 mm²/_s at 25° C.; (iii) a trialkylsiloxy terminated polyorganosiloxane fluid having a viscosity of 100,000-600,000 mm²/_s at 25° C.; (iv) a water soluble muco-adhesive polymer selected from the group consisting of a poly(ethylene oxide) polymer having a molecular weight of 100,000 to 8,000,000, an acrylic acid polymer having a molecular weight of 500,000 to 4,500,000,000, and a hydroxyethylcellulose polymer having a molecular weight of 90,000 to 1,300,000,000; and optionally, (v) a solvent selected from the group consisting of aliphatic hydrocarbons, aromatic hydrocarbons, esters, volatile linear and cyclic silicone compounds. Other components such as a silicone polyether, a silicone wax, a drug, an excipient, and/or an active ingredient can also be included.

Claims

1. A method of adhering a device to a wet biological surface, which comprises

applying to the device a silicone adhesive composition, wherein the silicone adhesive composition comprises:

(i) 13 to 25 weight percent of a silicone resin that a cohydrolysis product of a trialkyl hydrolyzable silane and an alkyl silicate in which the cohydrolysis product contains a plurality of silicon-bonded hydroxy groups;

(ii) 8 to 20 weight percent of a linear organopolysiloxane fluid containing terminal silicon-bonded hydroxy groups having a viscosity above 200,000 mm²/s at 25°

C.;

(iii) 5 to 30 weight percent of a trialkylsiloxy terminated polyorganosiloxane fluid having a viscosity of 100,000-600,000 mm²/s at 25°

C.;

(iv) 5 to 25 weight percent of a water soluble muco-adhesive polymer selected from the group consisting of a poly(ethylene oxide) polymer having a molecular weight of 100,000 to 8,000,000, an acrylic acid polymer having a molecular weight of 500,000 to 4,500,000,000, and a hydroxyethylcellulose polymer having a molecular weight of 90,000 to 1,300,000,000;

and optionally,

(v) up to 35 weight percent of a solvent selected from the group consisting of aliphatic hydrocarbons, aromatic hydrocarbons, esters, volatile linear and cyclic silicone compounds; and

placing the device with the applied silicone adhesive composition to the wet biological surface, wherein the device is a denture, a hairpiece, a prosthesis, an ostomy, a wound dressing, a tape, a buccal patch, or a transdermal patch, and the wet surface is skin, the buccal cavity, the gums, the mucosal linings of intranasal passages, the alimentary canal, vaginal and rectal walls, and wet components of botanical origin.

2. A method according to claim 1 in which the silicone adhesive composition further comprises up to 10 weight percent of a silicone polyether.

3. A method according to claim 1 in which the silicone adhesive composition further comprises up to 15 weight percent of a silicone wax.

4. A method according to claim 1 in which the silicone adhesive composition further comprises up to 35 weight percent of a drug, an excipient and/or an active ingredient.