Medical gas barrier film and medical bag using the same

• US 7,914,867 B2
• Filed: 10/13/2005
• Issued: 03/29/2011
• Est. Priority Date: 10/18/2004
• Status: Active Grant

• Current Assignee: Otsuka Pharmaceutical Factory Incorporated (Otsuka Holdings Company Limited)
• Original Assignee: Otsuka Pharmaceutical Factory Incorporated (Otsuka Holdings Company Limited)
• Inventors: Morimoto, Yasushi, Tateishi, Isamu, Konishi, Kenji, Mori, Hitoshi
• Primary Examiner(s): Patterson; Marc A
• Application Number:
  US11/665,384
• Publication Number:
  US 20080063825A1
• Time in Patent Office: 1,993 Days
• Field of Search: 428/34.1, 428/34.2, 428/35.7, 428/35.9, 428/34.3, 428/35.2, 428/474.4, 428/477.7, 428/480, 428/483, 428/500, 428/515
• US Class Current: 428/35.2
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: B32B 2255/10 on synthetic resin layer or on natural or synthetic rubber layer
• CPC Class Codes: B32B 2255/20 Inorganic coating
• CPC Class Codes: B32B 2274/00 Thermoplastic elastomer material
• CPC Class Codes: B32B 2307/306 Resistant to heat
• CPC Class Codes: B32B 2307/31 Heat sealable
• CPC Class Codes: B32B 2307/412 Transparent
• CPC Class Codes: B32B 2307/514 Oriented
• CPC Class Codes: B32B 2307/558 Impact strength, toughness
• CPC Class Codes: B32B 2307/7242 Non-permeable
• CPC Class Codes: B32B 2439/46 Bags
• CPC Class Codes: B32B 2439/80 Medical packaging
• CPC Class Codes: B32B 25/08 of synthetic resin
• CPC Class Codes: B32B 25/14 comprising synthetic rubber copolymers B32B25/18 and B32B25/20 take precedence
• CPC Class Codes: B32B 27/08 of synthetic resin
• CPC Class Codes: B32B 27/16 specially treated, e.g. irradiated
• CPC Class Codes: B32B 27/32 comprising polyolefins comprising vinyl (co)polymers or acrylic (co)polymers B32B27/30
• CPC Class Codes: B32B 27/325 comprising polycycloolefins
• CPC Class Codes: B32B 27/34 comprising polyamides
• CPC Class Codes: B32B 27/36 : comprising polyesters
• CPC Class Codes: B32B 7/12 : using interposed adhesives or interposed materials with bonding properties
• CPC Class Codes: Y10T 428/13 : Hollow or container type article [e.g., tube, vase, etc.]
• CPC Class Codes: Y10T 428/1303 : Paper containing [e.g., paperboard, cardboard, fiberboard, etc.]
• CPC Class Codes: Y10T 428/1307 : Bag or tubular film [e.g., pouch, flexible food casing, envelope, etc.]
• CPC Class Codes: Y10T 428/1334 : Nonself-supporting tubular film or bag [e.g., pouch, envelope, packet, etc.]
• CPC Class Codes: Y10T 428/1352 : Polymer or resin containing [i.e., natural or synthetic]
• CPC Class Codes: Y10T 428/1359 : Three or more layers [continuous layer]
• CPC Class Codes: Y10T 428/1379 : Contains vapor or gas barrier, polymer derived from vinyl chloride or vinylidene chloride, or polymer containing a vinyl alcohol unit
• CPC Class Codes: Y10T 428/2495 : Thickness [relative or absolute]
• CPC Class Codes: Y10T 428/2817 : Heat sealable
• CPC Class Codes: Y10T 428/31725 : Of polyamide
• CPC Class Codes: Y10T 428/31765 : Inorganic-containing or next to inorganic-containing
• CPC Class Codes: Y10T 428/31786 : Of polyester [e.g., alkyd, etc.]
• CPC Class Codes: Y10T 428/31797 : Next to addition polymer from unsaturated monomers
• CPC Class Codes: Y10T 428/31855 : Of addition polymer from unsaturated monomers
• CPC Class Codes: Y10T 428/31909 : Next to second addition polymer from unsaturated monomers

Abstract

The object of the present invention is to provide a gas barrier film suitable for medical uses, which is excellent in gas and vapor properties and can prevent ingredients of an adhesive and the like from eluting even after heating and sterilizing treatment, and a medical bag using the gas barrier film. A medical gas barrier film of the present invention comprises a multilayer gas barrier film 10 including a deposition oriented polyester layer 11 having a deposited layer 13 of an inorganic oxide on one surface, an oriented polyamide layer 15 adhered to the surface of the deposited layer 13 and a polyethylene layer 17 adhered to the surface on the opposite side to an adhered surface 15a of the oriented polyamide layer 15, and a multilayer substrate film 22 including a cyclic olefin polymer layer 25, an elastomer layers 24, 26 and a heat sealing layer 23, and the multilayer substrate film 22 is adhered to an other surface 11b on the opposite side of the deposited layer of the deposition oriented polyester layer 11.

Claims

1. A medical gas barrier film comprising a multilayer gas barrier film and a multilayer substrate film adhered to the multilayer gas barrier film, wherein

the multilayer gas barrier film has a three-layer structure consisting of three layers, which structure includes a deposition oriented polyester layer having a deposited layer of alumina on one surface thereof, an oriented polyamide layer adhered to a surface of the deposited layer of alumina on the one surface of the deposition oriented polyester layer and a polyethylene layer adhered to a surface of the oriented polyamide layer on the opposite side to the surface of the oriented polyamide layer adhered to the deposited layer of alumina,

the multilayer substrate film has a five-layer structure formed by laminating a heat sealing layer, a first elastomer layer, a cyclic olefin polymer layer, a second elastomer layer and a polyethylene layer in this order, and

a surface of the multilayer substrate film on the side of the polyethylene layer is adhered to a surface of the deposition oriented polyester layer of the multilayer gas barrier film opposite to said one surface of the deposition oriented polyester layer.

2. A medical gas barrier film as stated in claim 1, wherein a total thickness of the first elastomer layer and the second elastomer layer is 55 to 80% of a thickness of the multilayer substrate film.

3. A medical gas barrier film as stated in claim 1, wherein a thickness of the polyethylene layer of the multilayer gas barrier film is 1 or 2 times larger than a total thickness of the deposition oriented polyester layer and the oriented polyamide layer.

4. A medical gas barrier film as stated in claim 1, wherein the polyethylene layer of the multilayer gas barrier film is a three-layer film formed of a linear polyethylene film having a density of 0.910 to 0.930 g/cm³ and high density polyethylene films each having a density of 0.950 to 0.970 g/cm³ and adhered to both surfaces of the linear polyethylene layer, and a thickness of each of the high density polyethylene films is 0.2 to 0.3 times larger than that of the linear polyethylene film.

5. A medical gas barrier film as stated in claim 1, wherein the multilayer substrate film is a cylindrical film formed by inflation molding and an innermost layer of the cylindrical film is the heat sealing layer.

6. A medical bag formed by welding a medical gas barrier film so that heat sealing layers thereof face each other, wherein

the medical gas barrier film comprises a multilayer gas barrier film and a multilayer substrate film adhered to the multilayer gas barrier film,

the multilayer gas barrier film has a three-layer structure consisting of three layers, which structure includes a deposition oriented polyester layer having a deposited layer of alumina on one surface thereof, an oriented polyamide layer adhered to a surface of the deposited layer of alumina on the one surface of the deposition oriented polyester layer and a polyethylene layer adhered to a surface of the oriented polyamide layer on the opposite side to the surface of the oriented polyamide layer adhered to the deposited layer of alumina,

the multilayer substrate film has a five-layer structure formed by laminating a heat sealing layer, a first elastomer layer, a cyclic olefin polymer layer, a second elastomer layer and a polyethylene layer in this order, and

a surface of the multilayer substrate film on the side of the polyethylene layer is adhered to a surface of the deposition oriented polyester layer of the multilayer gas barrier film opposite to said one surface of the deposition oriented polyester layer.

8. A medical bag as stated in claim 6, the whole of which is subjected to heating and sterilization after being filled with a medical fluid and sealed.

7. A medical bag formed by welding an open end of a multilayer substrate film of a medical gas barrier film, wherein

the medical gas barrier film comprises a multilayer gas barrier film and a multilayer substrate film adhered to the multilayer gas barrier film,

the multilayer gas barrier film has a three-layer structure consisting of three layers, which structure includes a deposition oriented polyester layer having a deposited layer of alumina on one surface thereof, an oriented polyamide layer adhered to a surface of the deposited layer of alumina on the one surface of the deposition oriented polyester layer and a polyethylene layer adhered to a surface of the oriented polyamide layer on the opposite side to the surface of the oriented polyamide layer adhered to the deposited layer of alumina,

the multilayer substrate film is a cylindrical film formed by inflation molding and has a five-layer structure formed by laminating a heat sealing layer, a first elastomer layer, a cyclic olefin polymer layer, a second elastomer layer and a polyethylene layer in this order,

a surface of the multilayer substrate film on the side of the polyethylene layer is adhered to a surface of the deposition oriented polyester layer of the multilayer gas barrier film opposite to said one surface of the deposition oriented polyester layer, and

an innermost layer of the cylindrical multilayer substrate film is the heat sealing layer.

9. A medical bag as stated in claim 7, the whole of which is subjected to heating and sterilization after being filled with a medical fluid and sealed.