Device with a compressible matrix having homogeneous flow profile

• US 7,919,063 B2
• Filed: 09/05/2006
• Issued: 04/05/2011
• Est. Priority Date: 09/06/2005
• Status: Expired due to Fees

• Current Assignee: Roche Molecular Systems (Roche Holding AG)
• Original Assignee: Roche Molecular Systems (Roche Holding AG)
• Inventors: Sarofim, Emad
• Primary Examiner(s): Bullock; In Suk
• Assistant Examiner(s): Pregler; Sharon
• Application Number:
  US12/064,992
• Publication Number:
  US 20080206111A1
• Time in Patent Office: 1,673 Days
• Field of Search: 422/99, 422/68.1, 422/100, 422/101, 422/102, 422/61, 422/58, 210/496, 210/506, 210/435, 210/446, 210/505, 210/508, 210/509
• US Class Current: 422/513
• CPC Class Codes: B01L 2300/0861 Configuration of multiple channels and/or chambers in a single devices
• CPC Class Codes: B01L 2400/082 Active control of flow resistance, e.g. flow controllers
• CPC Class Codes: B01L 3/5023 with a sample being transported to, and subsequently stored in an absorbent for analysis
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/502746 characterised by the means for controlling flow resistance, e.g. flow controllers, baffles B01L3/502738 takes precedence
• CPC Class Codes: G01N 33/491 by separating the blood components G01N15/05 takes precedence

Abstract

A fluidic device containing a flow through chamber comprising an inlet port, an outlet port, and a fluid permeable, compressible matrix located in the chamber between said inlet port and said outlet port, and said compressible matrix having a higher flow resistance at higher compressions and a plurality of flow paths leading from said inlet port to said outlet port through said matrix comprising shorter and longer length flow paths, wherein said matrix is compressed in at least one dimension, being more strongly compressed along the shorter length flow paths than along the longer length flow path.

Claims

1. A fluidic device containing a flow through chamber, said chamber comprising:

an upper wall and an opposing lower wall separated by a distance,

one or more protrusions configured on at least one of said upper wall and said lower wall, the one or more protrusions successively reducing the distance between said upper wall and said lower wall,

an inlet port,

an outlet port, both ports are designed to allow a fluid to be treated in said chamber by flowing through said chamber,

a fluid permeable, compressible matrix located in the chamber between said upper wall and said lower wall, and between said inlet port and said outlet port, said compressible matrix having a higher flow resistance at a lower value of the Degree of Compression compared to at a higher value of the Degree of Compression a plurality of flow paths leading from said inlet port to said outlet port through said matrix comprising shorter length flow paths and longer length flow paths,

characterized in that said matrix is unequally compressed by said one or more protrusions, being more strongly compressed in the shorter length flow paths than in the longer length flow paths, such that the flow through times through said plurality of flow paths are at least partially equalized.

2. The device according to claim 1, wherein said dimension is orthogonal to the shorter length flow path.

3. The device according to claim 1, wherein the average degree of compression is smaller than 100% and the span of degree of compression is at least 5%.

4. The device according to claim 1, wherein the average degree of compression is smaller than 90% and the span of degree of compression is at least 10%.

5. The device according to claim 1, wherein the matrix is a fiber based fleece or a porous body.

6. The device according to claim 1, wherein the difference in compression is realized by a different height of the chamber.

7. The device according to claim 1, wherein the difference in compression is created by a different height of the chamber.

8. The device according to claim 1, wherein the height of said chamber, between said upper wall and said lower wall, is between 100% and 20% of the largest height of said chamber.

9. The device according to claim 1 wherein the ratio of the maximum distance between the side walls of the chamber and the maximum distance between the upper wall and the lower wall of the chamber is between 2:

1 and 500;

1.

10. The device according to claim 1, wherein the ratio of the length of the matrix measured along said shorter flow path to the width of said matrix is between 20:

1 and 1;

20.

11. The device according to claim 1, wherein the minimum distance between the upper wall and the lower wall is equal to or greater than 0.2 and equal to or less than 3 mm.

12. The device according to claim 1, wherein the geometry of said chamber between said inlet and said outlet is plane symmetric regarding the connection between said inlet and said outlet port.

13. The device according to claim 1, wherein the shape of the chamber harboring the matrix is circular or rectangular with rounded corners.

14. The device according to claim 1, wherein the shape of the matrix for the circular chamber is cylindrical.

15. The device according to claim 1, wherein the matrix comprises a material capable of binding a component of the fluid.

16. The device according to claim 1 wherein the matrix is compressed in said chamber in two orthogonal dimensions orthogonal to the flow direction, and wherein in at least one direction the degree of compression is varied.

17. The device according to claim 1, wherein said permeable, compressed matrix fills said chamber completely on at least one cross-section orthogonal to the flow paths of the chamber between said inlet port and said outlet port.

18. The device according to claim 1, wherein the matrix is a solid phase absorber, an ion exchanger or a carrier of reagents or a filter.

19. The device according to claim 1, characterized in that said matrix is a fleece.

20. The device according to claim 1, wherein said inlet and outlet ports are located at opposing positions of the chamber.