Anti-IL-6 monoclonal antibodies
First Claim
Patent Images
1. An isolated monoclonal antibody comprising:
- (a) a variable heavy chain region (VH) comprising;
(i) a VH-CDR1 comprising an amino acid sequence selected from the group consisting of;
SEQ ID NO;
51, SEQ ID NO;
52, SEQ ID NO;
53, SEQ ID NO;
54, and SEQ ID NO;
55;
(ii) a VH-CDR2 comprising an amino acid sequence selected from the group consisting of;
SEQ ID NO;
56, SEQ ID NO;
57, SEQ ID NO;
58, SEQ NO;
59, SEQ ID NO;
60, SEQ ID NO;
61, SEQ ID NO;
97 and SEQ ID NO;
101;
(iii) a VH-CDR3 comprising an amino acid sequence selected from the group consisting of;
SEQ ID NO;
62, SEQ ID NO;
63, SEQ ID NO;
64, SEQ ID NO;
65, SEQ ID NO;
66, SEQ ID NO;
67, SEQ ID NO;
68, SEQ ID NO;
69, SEQ ID NO;
70, SEQ ID NO;
71, SEQ ID NO;
72, SEQ ID NO;
73, and SEQ ID NO;
98; and
(b) a variable light chain region (VL) comprising;
(i) a VL-CDR1 comprising an amino acid sequence selected from the group consisting of;
SEQ ID NO;
74, SEQ ID NO;
75, SEQ ID NO;
76, SEQ ID NO;
77, SEQ ID NO;
78, and SEQ ID NO;
79;
(ii) a VL-CDR2 comprising an amino acid sequence selected from the group consisting of;
SEQ ID NO;
80, SEQ ID NO;
81, SEQ ID NO;
82, SEQ ID NO;
83, SEQ ID NO;
84, and SEQ ID NO;
85;
(iii) a VL-CDR3 comprising an amino acid sequence selected from the group consisting of;
SEQ ID NO;
86, SEQ ID NO;
87, SEQ ID NO;
88, SEQ ID NO;
89, SEQ ID NO;
90, SEQ ID NO;
91, SEQ ID NO;
92, SEQ ID NO;
93, SEQ ID NO;
94, SEQ ID NO;
95, and SEQ ID NO;
96;
wherein said antibody binds specifically to an IL-6 antigen.
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Abstract
The present invention provides novel monoclonal antibodies that bind specifically to IL-6. The antibodies of the invention comprise a variable heavy chain (VH) region selected from any of the VH regions disclosed herein as well as amino acid variants thereof, and/or a variable light chain (VL) region selected from any of the VL regions disclosed herein as well as amino acid variants thereof. The invention also provides methods of treating diseases and disorders associated with IL-6 expression and/or activity.
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Citations
9 Claims
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1. An isolated monoclonal antibody comprising:
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(a) a variable heavy chain region (VH) comprising; (i) a VH-CDR1 comprising an amino acid sequence selected from the group consisting of;
SEQ ID NO;
51, SEQ ID NO;
52, SEQ ID NO;
53, SEQ ID NO;
54, and SEQ ID NO;
55;(ii) a VH-CDR2 comprising an amino acid sequence selected from the group consisting of;
SEQ ID NO;
56, SEQ ID NO;
57, SEQ ID NO;
58, SEQ NO;
59, SEQ ID NO;
60, SEQ ID NO;
61, SEQ ID NO;
97 and SEQ ID NO;
101;(iii) a VH-CDR3 comprising an amino acid sequence selected from the group consisting of;
SEQ ID NO;
62, SEQ ID NO;
63, SEQ ID NO;
64, SEQ ID NO;
65, SEQ ID NO;
66, SEQ ID NO;
67, SEQ ID NO;
68, SEQ ID NO;
69, SEQ ID NO;
70, SEQ ID NO;
71, SEQ ID NO;
72, SEQ ID NO;
73, and SEQ ID NO;
98; and(b) a variable light chain region (VL) comprising; (i) a VL-CDR1 comprising an amino acid sequence selected from the group consisting of;
SEQ ID NO;
74, SEQ ID NO;
75, SEQ ID NO;
76, SEQ ID NO;
77, SEQ ID NO;
78, and SEQ ID NO;
79;(ii) a VL-CDR2 comprising an amino acid sequence selected from the group consisting of;
SEQ ID NO;
80, SEQ ID NO;
81, SEQ ID NO;
82, SEQ ID NO;
83, SEQ ID NO;
84, and SEQ ID NO;
85;(iii) a VL-CDR3 comprising an amino acid sequence selected from the group consisting of;
SEQ ID NO;
86, SEQ ID NO;
87, SEQ ID NO;
88, SEQ ID NO;
89, SEQ ID NO;
90, SEQ ID NO;
91, SEQ ID NO;
92, SEQ ID NO;
93, SEQ ID NO;
94, SEQ ID NO;
95, and SEQ ID NO;
96;wherein said antibody binds specifically to an IL-6 antigen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification