Surface treatment of biomedical devices

• US 7,919,136 B2
• Filed: 11/20/2007
• Issued: 04/05/2011
• Est. Priority Date: 12/15/2006
• Status: Expired due to Fees

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Inventors: Künzler, Jay F., Linhardt, Jeffrey G.
• Primary Examiner(s): Barr; Michael
• Assistant Examiner(s): BOWMAN, ANDREW J
• Application Number:
  US11/874,427
• Publication Number:
  US 20080143957A1
• Time in Patent Office: 1,232 Days
• Field of Search: 435/5, 523/107, 427/2.1
• US Class Current: 427/2.1
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/14 Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: C08J 2433/00 Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
• CPC Class Codes: C08J 7/0427 with only one layer of a composition containing a polymer binder with more layers C08J7/042
• CPC Class Codes: C08J 7/052 Forming heat-sealable coatings
• CPC Class Codes: C08J 7/056 Forming hydrophilic coatings
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: C09D 133/02 Homopolymers or copolymers of acids; Metal or ammonium salts thereof
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

A surface modified biomedical device is provided comprising a biomedical device having a coating on at least a portion thereof, the coating comprising a polymer or copolymer having one or more repeating units of the formula:

wherein R independently is a C₂-C₂₀ hydrocarbon radical and n is an integer of 2 to 5000.

Claims

1. A method comprising:

(a) immersing an ophthalmic device in a solution comprising a polymer or copolymer having one or more repeating units of the formula;

2. The method of claim 1, wherein the biomedical device is a contact lens.

3. The method of claim 1, wherein the biomedical device is a silicone hydrogel contact lens.

4. The method of claim 1, wherein R is a C₂-C₆ straight chain or branched alkyl group.

5. The method of claim 1, wherein R is an ethyl or propyl group.

6. The method of claim 1, wherein the polymer or copolymer is obtained from the polymerization or copolymerization of a monomeric mixture comprising one or more C₂-C₆ straight chain, branched, and cyclic 2-alpha-alkyl acrylic acids.

7. The method of claim 6, wherein the monomeric mixture further comprises one or more hydrophilic monomers.

8. The method of claim 1, further comprising hermetically sealing the device and the solution in the package.

9. The method of claim 8, wherein heat sterilization is performed subsequent to sealing of the package.

10. The method of claim 1, wherein the solution does not contain an effective disinfecting amount of a disinfecting agent.

11. The method of claim 1, wherein the solution does not contain a germicide compound.