Systems and methods for increasing implantable sensor accuracy

• US 7,920,913 B1
• Filed: 06/29/2007
• Issued: 04/05/2011
• Est. Priority Date: 06/29/2007
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Nabutovsky, Yelena, Ryu, Kyungmoo, Bornzin, Gene A., Farazi, Taraneh Ghaffari
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Stice; Paula J
• Application Number:
  US11/771,514
• Time in Patent Office: 1,376 Days
• Field of Search: 600/511
• US Class Current: 600/509
• CPC Class Codes: A61B 2560/02 Operational features
• CPC Class Codes: A61B 5/14551 for measuring blood gases

Abstract

Provided herein are implantable systems, and methods for use therewith, that increase the accuracy of measurements produced using an implanted sensor, where the measurements are affected by cycles of a cyclical body function (e.g., heart beat and/or respiration). In accordance with specific embodiments of system, a measurement that is presumed to be accurate is obtained. The measurement can be of a physiologic property, such as, but not limited to, blood oxygen saturation, hematocrit, or blood glucose concentration. Additionally, the implanted is used to produce a plurality of measurements of the physiologic property. Such measurements, produced using the implanted sensor, are compared to the measurement presumed to be accurate to thereby identify when the measurements produced using the implanted sensor are most accurate. Thereafter, the implanted system is configured to use the implanted sensor to produce measurements when the measurements produced using the implanted sensor are most accurate.

Claims

1. A method for increasing accuracy of measurements produced using an implanted sensor implanted within a patient, where the measurements produced using the implanted sensor are affected by cycles of a cyclical body function, the method comprising:

(a) obtaining an accurate measurement of a physiologic property for the patient;

(b) using the implanted sensor to produce a plurality of measurements of a same physiologic property as the physiologic property for which the accurate measurement is obtained at step (a);

(c) comparing the measurements produced using the implanted sensor at step (b) to the accurate measurement obtained at step (a) to thereby identify when relative to the cyclical body function the measurements produced using the implanted sensor are most accurate; and

(d) configuring the implanted system to thereafter use the implanted sensor to produce measurements of the same physiologic property when the measurements produced using the implanted sensor are most accurate as identified at step (c).

2. The method of claim 1, wherein:

step (c) comprises comparing the measurements produced using the implanted sensor to the accurate measurement obtained at step (a) to thereby identify a portion of cycles of the cyclical body function when the measurements produced using the implanted sensor are most accurate; and

step (d) comprises configuring the implanted system to thereafter use the implanted sensor to produce measurements during the identified portion of cycles of the cyclical body function.

3. The method of claim 2, wherein:

step (c) comprises identifying a portion of cardiac cycles, when the measurements produced using the implanted sensor are most accurate, relative to a detectable cardiac event as detected from a signal representative of cardiac activity.

4. The method of claim 2, wherein:

step (c) includes identifying a portion of cardiac cycles, when the measurements produced using the implanted sensor are most accurate, relative to a detectable feature of a sensor signal produced by the implanted sensor.

5. The method of claim 1, wherein:

step (b) comprises

(b.1) obtaining a sensor signal from the implanted sensor; and

(b.2) producing a plurality of measurements based on the sensor signal;

step (c) comprises comparing the measurements based on the sensor signal to the accurate measurement obtained at step (a) to thereby identify a portion of cycles of the cyclical body function when the measurements based on the sensor signal are most accurate; and

step (d) comprises configuring the implanted system to thereafter produce measurements based on a portion of the sensor signal that corresponds to the identified portion of cycles of the cyclical body function.

6. The method of claim 5, wherein the cyclical body function is heart beat, and the cycles of the cyclical body function are cardiac cycles.

7. The method of claim 6, wherein:

step (d) including identifying the portion of cardiac cycles, when the measurements based on the sensor signal are most accurate, relative to a detectable cardiac event.

8. The method of claim 7, wherein in step (d) the identifying includes determining at what time interval after specific detected features of a signal indicative of cardiac activity the measurements based on the sensor signal are most accurate.

9. The method of claim 6, wherein in step (d) the identifying includes determining at what percentage of cyclical cardiac intervals the measurements based on the sensor signal are most accurate.

10. The method of claim 5, wherein the cyclical body function is respiration, and the cycles of the cyclical body function are respiratory cycles.

11. The method of claim 10, wherein:

step (d) including identifying the portion of respiratory cycles, when the measurements based on the sensor signal are most accurate, relative to a detectable respiratory event.

12. The method of claim 10, wherein:

step (d) including identifying the portion of respiratory cycles, when the measurements based on the sensor signal are most accurate, relative to a detectable feature of a low-pass filtered version of the sensor signal.

13. The method of claim 5, wherein:

the sensor signal is affected by both cardiac cycles of heart beat and respiratory cycles of respiration; and

step (d) includes identifying when the measurements based on the sensor signal are most accurate relative to both detectable cardiac and respiratory events.

14. The method of claim 5, wherein the physiologic property comprises one of venous oxygen saturation, hematocrit and blood glucose concentration.

15. The method of claim 5, wherein:

step (b) is performed for a plurality of different cycle rates; and

step (c) includes identifying the portion of cycles of the cyclical body function when the measurements based on the sensor signal are most accurate for the plurality of cycle rates.

16. The method of claim 5, wherein:

step (b) is performed for a plurality of different cycle rates;

step (c) includes identifying, for each of the different cycle rates, the portion of cycles of the cyclical body function when the measurements based on the sensor signal are most accurate; and

step (d) includes configuring the implanted system to thereafter produce measurements based on the sensor signal during the identified portion of cycles of the cyclical body function, wherein the identified portion of the cycles is dependent upon the cycle rate.

17. The method of claim 5, further comprising:

determining an offset between the measurements based on the sensor signal produced at step (b) and the accurate measurement obtained at step (a); and

configuring the implantable system to adjust the measurements, produced using the implanted sensor during the identified portion of the cycles of the cyclical body function, using the determined offset.

18. The method of claim 1, wherein step (c) includes identifying, a portion of cycles of the cyclical body function when the measurements produced using the implanted sensor are closest to the accurate measurement obtained at step (a).

19. A method for increasing accuracy of measurements based on a sensor signal obtained from an implanted sensor of an implanted system implanted within a patient, where the sensor signal is affected by cycles of a cyclical body function, the method comprising:

(a) obtaining an accurate measurement of a physiologic property for the patient;

(b) producing, based on the sensor signal, a plurality of measurements of the a same physiologic property as the physiologic property for which the accurate measurement is obtained at step (a);

(c) comparing the measurements based on the sensor signal to the accurate measurement to thereby identify a portion of cycles of the cyclical body function when the measurements based on the sensor signal are most accurate; and

(d) producing measurements based on a portion of the sensor signal that corresponds to the identified portion of cycles of the cyclical body function.

20. The method of claim 19, wherein step (c) includes identifying, a portion of cycles of the cyclical body function when the measurements produced based on the sensor signal are closest to the accurate measurement obtained at step (a).

21. An implantable system, comprising:

an implantable sensor that can be used to produce measurements of a physiologic property, where the measurements are affected by cycles of a cyclical body function; and

one or more processor configured to;

compare measurements produced using the implanted implantable sensor to a separate accurate measurement of a same physiologic property to thereby identify when relative to the cyclical body function the measurements produced using the implantable sensor are most accurate; and

thereafter use the implantable sensor to produce measurements of the same physiologic property when the measurements produced using the implantable sensor are most accurate as identified.

22. The implantable system of claim 21, wherein:

the implantable sensor produces a sensor signal from which measurements of the same physiologic property can be made; and

the one or more processor is configured to;

identify a portion of cycles of the cyclical body function when the measurements produced based on the sensor signal are most accurate; and

thereafter use the implantable sensor to produce measurements based on a portion of the sensor signal that corresponds to the identified portion of cycles of the cyclical body function.

23. The implantable system of claim 22, further comprising:

a filter to low-pass filter the sensor signal to produce a low-pass filtered version of the sensor signal; and

wherein the one or more processor is configured to identify the portion of respiratory cycles, when the measurements based on the sensor signal are most accurate, relative to a detectable feature of the low-pass filtered version of the sensor signal.

24. The implantable system of claim 22, wherein:

the sensor signal is affected by both cardiac cycles of heart beat and respiratory cycles of respiration; and

the one or more processor is configured to identify when the measurements based on the sensor signal are most accurate relative to both detectable cardiac and respiratory events.

25. The implantable system of claim 22, wherein:

the one or more processor is also configured to;

determine an offset between the measurements based on the sensor signal and the accurate measurement; and

adjust the measurements, produced based on the sensor signal, using the determined offset.

26. The implantable system of claim 22, wherein the one or more processor is configured to identify a portion of cardiac cycles, when the measurements produced using the implantable sensor are most accurate, relative to a detectable cardiac event as detected from a signal representative of cardiac activity.

27. The implantable system of claim 22, wherein the one or more processor is configured to identify a portion of cardiac cycles, when the measurements produced using the implantable sensor are most accurate, relative to a detectable feature of the sensor signal produced by the implantable sensor.

28. The implantable system of claim 22, wherein the one or more processor is configured to identify a portion of respiratory cycles, when measurements produced using the implantable sensor are most accurate, relative to a detectable respiratory event.

29. The implantable sensor of claim 21, wherein the one or more processor is configured to identify, a portion of cycles of the cyclical body function when the measurements produced based on the sensor signal are closest to the separate accurate measurement of the same physiologic property.