Method and apparatus utilizing animals for detecting target substances

• US 7,921,810 B2
• Filed: 11/19/2006
• Issued: 04/12/2011
• Est. Priority Date: 11/18/2005
• Status: Active Grant

• Current Assignee: Bio Explorers Ltd.
• Original Assignee: Bio Explorers Ltd.
• Inventors: Lumbroso, Alon, Lumbroso, Eran
• Primary Examiner(s): Swiatek; Rob
• Assistant Examiner(s): EVANS, EBONY E
• Application Number:
  US12/085,021
• Publication Number:
  US 20090145369A1
• Time in Patent Office: 1,605 Days
• Field of Search: 119/417, 119/421, 119/221, 119/472, 119/473, 340/573.1
• US Class Current: 119/421
• CPC Class Codes: A01K 15/02 Training or exercising equipment, e.g. mazes or labyrinths for animals A01K15/04 takes precedence; Electric shock devices circuits therefor H03K3/537; Toys specially adapted for animals
• CPC Class Codes: A61K 49/0008 Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure

Abstract

A method and apparatus for detecting a target substance in a monitored environment involves, in a training phase, training at least one animal capable of detecting the target substance to execute a particular avoidance action, immediately upon detecting said target substance, in order to avoid particular aversive stimulus;

• • and in an operational phase, exposing the trained animal to a specimen (e.g., air) from the monitored environment or object, and sensing when the animal has executed the particular avoidance action.

Claims

1. A method of detecting a target substance in a monitored environment or object, comprising:

(a) in a training phase, training at least one animal capable of detecting said target substance to execute a particular avoidance action, immediately upon detecting said target substance, in order to avoid a particular adverse stimulus;

(b) in an operational phase, exposing said trained animal to a specimen of said monitored environment or object, and sensing when said animal has executed said particular avoidance action.

2. The method according to claim 1, wherein, in both the training phase and the operational phase, said animal is housed within a cage including the basic living necessities for the animal.

3. The method according to claim 2, wherein said particular adverse stimulus is an electrical, audible, visual, thermal, or mechanical stimulus which the animal naturally wishes to avoid.

4. The method according to claim 2, wherein said particular avoidance action is one which the animal would normally not perform when the target substance is not detected.

5. The method according to claim 4, wherein said particular avoidance action is to move to a section of the cage which is accessible to the animal only with some difficulty.

6. The method according to claim 2, wherein, during the operational phase, the target substance is occasionally injected into said cage to verify the ability of the animal to detect the target substance.

7. The method according to claim 6, wherein, during the operational phase, a neutral substance is occasionally injected into said cage to verify the ability of the animal to distinguish between neutral substances and the target substance.

8. The method according to claim 2, wherein, during the training phase, an alerting stimulus is produced immediately after the exposure of the animal to the target substance to alert the animal to the fact that a target substance was present.

9. The method according to claim 2, wherein, during the training phase, a “

safety”

stimulus is produced immediately after sensing said avoidance action.

10. The method according to claim 2, wherein, during at least said operational phase, the cage includes a plurality of animals each trained to detect a target substance.

11. The method according to claim 10, wherein at least one of said animals in the cage is trained to detect a different target substance from at least one other of said animals.

12. The method according to claim 10, wherein at least one of said animals in the cage is trained to perform a different avoidance action than at least one other of said animals.

13. The method according to claim 10, wherein a section of said cage is subjected to an arousing stimulus to arouse any of the animals occupying that section of the cage.

14. The method according to claim 1, wherein said animal is selected from the group consisting of rats, mice, dwarf hamsters, gerbils, shrews, dogs, monkeys, birds, insects and fish.