Pulse oximeter based techniques for controlling anesthesia levels and ventilation levels in subjects

• US 7,922,666 B2
• Filed: 09/20/2007
• Issued: 04/12/2011
• Est. Priority Date: 09/21/2006
• Status: Expired due to Fees

• Current Assignee: STARR Life Sciences Corp.
• Original Assignee: STARR Life Sciences Corp.
• Inventors: Starr, Eric W, Ayers, Eric J, Hete, Bernard F.
• Primary Examiner(s): Marmor, II; Charles A
• Assistant Examiner(s): Choi; Jeffrey
• Application Number:
  US11/858,881
• Publication Number:
  US 20080072906A1
• Time in Patent Office: 1,300 Days
• Field of Search: 600322-341, 600/481, 600/484, 600/500, 600/529
• US Class Current: 600/500
• CPC Class Codes: A61B 2503/40 Animals
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/4821 Determining level or depth of anaesthesia A61B5/1106 takes precedence
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B
• CPC Class Codes: A61M 16/00 Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes stimulating the respiratory movement by mechanical, pneumatic or electrical means, iron lungs combined with gas breathing means A61H31/00
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/01 specially adapted for anaesthetising A61M16/104, A61M16/18 take precedence
• CPC Class Codes: A61M 16/024 including calculation means, e.g. using a processor

Abstract

Medical devices and techniques derive breath rate, breath distention, and pulse distention measurements of a subject from a pulse oximeter system coupled to the subject. These parameters together with the conventional physiologic parameters obtained from a pulse oximeter system can be used to assist in controlling the ventilation levels and the anesthesia levels of the subject. The development has human applications and particular application for animal research.

Claims

1. A non-invasive pulse oximetry system for controlling anesthesia levels in subjects comprising:

A light source adapted to be attached to an external appendage of a subject and configured to emit at least two distinct wavelengths of light directed at the appendage; and

A receiver adapted to be attached to the external appendage of a subject and configured to receive the light from the light source that has been directed at the appendage and generating received signals there from, wherein the pulse oximetry system derives a plurality of physiologic parameters of the subject from the received signals, and wherein the system will signal at least one alarm when the physiologic parameters are indicative of improper anesthesia levels in the subject, and wherein the physiologic parameters derived by the system include arterial pulse distention measurements and arterial breath distention measurements and wherein at least one alarm associated with anesthesia levels is based upon a comparison of the arterial distention measurements.

2. The non-invasive pulse oximetry system of claim 1 wherein the plurality of physiologic parameters further include the breath rate and the heart rate of the subject, and wherein at least one alarm associated with anesthesia levels is based upon the ratio of the heart rate and the breath rate.

3. The non-invasive pulse oximetry system of claim 2 wherein the parameter-based alarms associated with anesthesia levels which are based upon the ratio of the heart rate and the breath rate include an alarm when the heart rate per breath rate of the subject exceeds about 7.5 and an alarm when the heart rate per breath rate of the subject is below about 3.5.

4. The non-invasive pulse oximetry system of claim 1 wherein the parameter-based alarms associated with anesthesia levels which are based upon the comparison of the arterial distention measurements include at least one alarm associated with anesthesia levels when the breath distention of the subject exceeds the pulse distention of the subject and at least one alarm associated with anesthesia levels when the breath distention of the subject is less than about twenty percent of the pulse distention of the subject.

5. The non-invasive pulse oximetry system of claim 1 wherein the physiologic parameters derived by the system further include at least heart rate, blood oxygenation, breath distention measurements and breath rate of the subject and wherein at least one alarm associated with anesthesia levels is provided when an increase in the breath distention measurement coupled with a decrease in the blood oxygenation and a drop in one or both of the breath rate and the heart rate is considered to be indicative of the subject moving to a higher or deeper anesthesia level.

6. The non-invasive pulse oximetry system of claim 1 wherein a breath distention measurement that is less than the pulse distention is indicative of proper anesthesia levels.

7. The non-invasive pulse oximetry system of claim 1 wherein an increase in the breath distention measurement relative to the pulse distention measurement is used as an indicator for possible improper anesthesia levels.

8. A method for controlling anesthesia levels in subjects comprising:

Attaching a light source and receiver to an external appendage of a subject;

Emitting at least two distinct wavelengths of light directed at the appendage from the light source;

Receiving the light from the light source that has been directed at the appendage at the receiver;

Generating received signals from the light received at the receiver;

Deriving a plurality of physiologic parameters of the subject from the received signals;

Generating at least one alarm when the physiologic parameters are indicative of improper anesthesia levels in the subject, wherein the plurality of physiologic parameter include arterial pulse distention measurements and arterial breath distention measurements and wherein at least one alarm associated with anesthesia levels is based upon a comparison of the arterial distention measurements; and

Controlling anesthesia levels based upon at least some of the physiologic parameters.

9. The method for controlling anesthesia levels according to claim 8 wherein the plurality of physiologic parameters further include the breath rate and the heart rate of the subject, and wherein at least one alarm associated with anesthesia levels is based upon the ratio of the heart rate and the breath rate.

10. A non-invasive pulse oximetry system configured for controlling anesthesia levels in subjects comprising:

A light source adapted to be attached to an external appendage of a subject and configured to emit at least two distinct wavelengths of light directed at the appendage;

A receiver adapted to be attached to the external appendage of a subject and configured to receive the light from the light source that has been directed at the appendage and generating received signals there from, wherein the pulse oximetry system derives at least a heart rate and a breath rate of the subject from the received signals; and

An alarm configured to be signaled when the ratio of heart rate and breath rate is beyond preset thresholds, and wherein the system calculates arterial pulse and breath distention measurements, and further including an alarm configured to be signaled when a comparison of pulse distention and breath distention is beyond preset thresholds.

11. The non-invasive pulse oximetry system configured for controlling anesthesia levels in subjects of claim 10 wherein the alarm comparing distention measurements is signaled when the breath distention of the subject exceeds the pulse distention of the subject and when the breath distention of the subject is less than about twenty percent of the pulse distention of the subject.

12. The non-invasive pulse oximetry system configured for controlling anesthesia levels in subjects of claim 10 wherein the alarm based upon the ratio of the heart rate and the breath rate is signaled when the heart rate per breath rate of the subject exceeds about 7.5 and when the heart rate per breath rate of the subject is below about 3.5.

13. A method of controlling at least one of the anesthesia level or ventilators settings of a subject that is receiving at least one of anesthesia or respiratory support through a ventilator, the method comprising the steps of providing a non-invasive sensor pulse oximetry system configured to calculate arterial distention measurements of the subject, and using the measured arterial distention measurements as indicators for at least one of proper and improper levels of anesthesia or proper and improper ventilator control settings wherein the non-invasive sensor system further calculates breath and pulse distention measurements and wherein a breath distention measurement that is less than the pulse distention is indicative of proper anesthesia levels and/or proper ventilation settings.

14. The method according to claim 13 wherein the non-invasive sensor system further calculates breath distention measurements, blood oxygenation, heart rate, and breath rate of the subject and wherein an increase in the breath distention measurement coupled with a decrease in the blood oxygenation and a drop in one or both of the breath rate and the heart rate is considered to be indicative of the subject moving to a higher or deeper anesthesia level.

15. The method according to claim 13 wherein the non-invasive sensor system further calculates breath and pulse distention measurements and wherein an increase in the breath distention measurement relative to the pulse distention measurement is used as an indicator for possible improper anesthesia levels and/or ventilation settings.