Systems and methods for performing peritoneal dialysis

• US 7,922,686 B2
• Filed: 07/17/2003
• Issued: 04/12/2011
• Est. Priority Date: 07/19/2002
• Status: Active Grant

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Childers, Robert W., Lauman, Brian, Pan, Lee
• Primary Examiner(s): Sirmons; Kevin C
• Assistant Examiner(s): Schell; Laura C
• Application Number:
  US10/624,150
• Publication Number:
  US 20040019320A1
• Time in Patent Office: 2,826 Days
• Field of Search: 604/4.01, 604/5.01, 604/6.11, 604/27, 604/28, 604/29, 604/30, 604/93.01
• US Class Current: 604/29
• CPC Class Codes: A61M 1/166 Heating for sterilisation A61M1/1686
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/281 Instillation other than by gravity
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]

Abstract

Systems and methods for providing multiple pass continuous flow dialysis therapy are provided. The present invention includes a fluid circuit connected to a patient via a catheter thereby defining a fluid loop along which a therapy fluid including a dialysate can be continuously circulated into, through and out of a peritoneal cavity of a patient to remove a therapeutically effective amount of excess water and solutes including uremic toxins. The feed rate and discharge rate of therapy fluid into the fluid loop can be controllably regulated in proportion to the circulation rate of fluid in the fluid loop such that the therapy fluid can pass a multiple number of times along the fluid loop prior to discharge.

Claims

1. A system for providing peritoneal dialysis to a patient, the system comprising:

a catheter having an inflow lumen and an outflow lumen in communication with the patient'"'"'s peritoneal cavity; and

a fluid circuit in fluid communication with the catheter, the fluid circuit comprising;

a fluid loop, the fluid loop configured to circulate dialysate into, through and out of a peritoneal cavity of the patient at an outflow rate from the peritoneal cavity greater than an inflow rate to the peritoneal cavity,

a supply of a dialysate coupled to the fluid circuit, and

at least one of a (i) a chamber coupled to the fluid loop through which the dialysate can be fed at a feed rate into the fluid loop, and (ii) a cleaning device coupled to the fluid loop via a cleaning fluid path wherein the dialysate can be fed into the cleaning fluid path and cleaned at a cleaning rate prior to reintroduction into the fluid loop;

a discharge fluid path coupled to the fluid loop; and

a cycler that pumps the dialysate into the fluid circuit at a feed rate and circulates the dialysate at a circulation rate along the fluid loop to remove a therapeutic effective amount of solutes and excess water from the patient, the cycler further configured to drain the dialysate from the fluid circuit at a discharge rate that is less than the circulation rate and at least substantially equal to a difference between the outflow rate and the inflow rate, allowing the dialysate to be circulated a plurality of times along the fluid loop prior to discharge.

2. The system of claim 1 further comprising at least one pressure sensor coupled to the fluid circuit for sensing a pressure.

3. The system of claim 2 wherein the feed rate and the discharge rate are maintained at an approximately equal rate that is about one half of the circulation rate allowing the dialysate to circulate about two times along the fluid loop.

4. The system of claim 1 wherein the feed rate and the discharge rate are maintained at an approximately equal rate that is about one third of the circulation rate such that the dialysate is capable of circulating about three times along the fluid loop.

5. The system of claim 1 wherein the cycler comprises two pumps.

6. The system of claim 1 wherein the cleaning device contains sorbents for adsorbing at least one of urea, phosphate and creatinine.

7. The system of claim 1 wherein the cleaning device contains an ion exchange resin.

8. The system of claim 1 wherein the cleaning device contains at least one electrolyte for addition to the dialysate.

9. The system of claim 1, wherein the cleaning device contains at least three layers.

10. The system of claim 1, the chamber allowing the fluid loop to accommodate a variable increase in the dialysate during treatment.

11. The system of claim 10 wherein the variable increase in dialysate is due to an addition of ultrafiltrate to the fluid loop as the dialysate dialyzes the patient.

12. The system of claim 1 further comprising at least one valve connecting the catheter to the fluid circuit.

13. A system for providing peritoneal dialysis to a patient, the system comprising:

a catheter having an inflow lumen and outflow lumen in communication with the patient'"'"'s peritoneal cavity; and

a fluid circuit in fluid communication with the catheter thereby defining only a single fluid loop capable of circulating dialysate into, through and out of the peritoneal cavity at an outflow rate from the peritoneal cavity greater than an inflow rate to the peritoneal cavity, the fluid circuit comprising;

a supply of a dialysate coupled to the fluid loop,

a cleaning device coupled to the fluid loop via a cleaning fluid path wherein the dialysate can be fed into the cleaning fluid path and cleaned at a cleaning rate prior to reintroduction into the fluid loop, and

a discharge fluid path coupled to the fluid loop; and

a cycler that pumps the dialysate into the fluid loop at a feed rate and circulates the dialysate along the fluid loop at a circulation rate to remove a therapeutic effective amount of solutes and excess water from the patient, the cycler further configured to drain dialysate at a discharge rate approximately equal to a difference between the outflow rate and the inflow rate, the discharge rate effective to circulate the dialysate a plurality of times along the fluid loop prior to discharge.

14. The system of claim 13 wherein the fluid loop is coupled to the supply of dialysate, the cleaning fluid path and the discharge fluid path via a cycler.

15. The system of claim 14 wherein the cycler includes a fluid circuit coupled to a pumping mechanism and a plurality of valves such that the cycler is capable of automatically controlling the flow of dialysate into and out of the fluid loop during treatment.

16. The system of claim 13 wherein the cleaning device contains a sorbent material capable of non-selective removal of solutes from the dialysate prior to reuse.

17. The system of claim 16 wherein the sorbent material is selected from the group consisting of carbon, activated charcoal and combinations thereof.

18. The system of claim 13 wherein the cleaning device contains an ion exchange resin.

19. The system of claim 13 wherein the cleaning device contains a sorbent material capable of selective removal of solutes from the dialysate.