Biosensors and methods of using the same
First Claim
1. A biosensor to determine the concentration of an analyte in a sample, the biosensor comprising:
- (a) an electrode support;
(b) an electrode arrangement on the electrode support;
(c) a cover;
(d) a spacer layer providing a sample chamber between the electrode support and the cover, at least a portion of the electrode arrangement present in the sample chamber, the sample chamber having a volume of no more than about 1 microliter; and
(e) an incompressible element placed in-between said cover and said spacer layer, said incompressible element providing at least one vent in the sample chamber.
2 Assignments
0 Petitions
Accused Products
Abstract
A biosensor strip having a low profile for reducing the volume of liquid sample needed to perform an assay. In one embodiment, the biosensor strip includes an electrode support; an electrode arrangement on the electrode support; a cover; a sample chamber; and an incompressible element placed between the cover and the electrode support, the incompressible element providing an opening in at least one side or in the distal end of the sample chamber to provide at least one vent in the sample chamber. In another embodiment, the biosensor strip has an electrode support; an electrode arrangement on the electrode support; a cover; and a sample chamber, the cover having a plurality of openings formed therein, at least one of the openings in register with the sample chamber. The invention further includes methods for preparing such a biosensor strips in a continuous manner.
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Citations
32 Claims
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1. A biosensor to determine the concentration of an analyte in a sample, the biosensor comprising:
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(a) an electrode support; (b) an electrode arrangement on the electrode support; (c) a cover; (d) a spacer layer providing a sample chamber between the electrode support and the cover, at least a portion of the electrode arrangement present in the sample chamber, the sample chamber having a volume of no more than about 1 microliter; and (e) an incompressible element placed in-between said cover and said spacer layer, said incompressible element providing at least one vent in the sample chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A biosensor to determine the concentration of an analyte in a sample, the biosensor comprising:
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(a) an electrode support having an electrode arrangement thereon; (c) a cover; (d) a spacer layer providing a sample chamber between the electrode support and the cover, at least a portion of the electrode arrangement present in the sample chamber, the sample chamber having a volume of no more than about 0.3 microliters; (e) an incompressible element placed in-between said cover and said spacer layer, the incompressible element providing an opening in at least one of the first side, the second side or in the distal end of the sample chamber to provide at least one vent in the sample chamber; and (f) the biosensor configured to determine the concentration of the analyte within about 10 seconds. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24)
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25. A method of determining the concentration of an analyte comprising:
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(a) providing a biosensor comprising; (i) an electrode support having an electrode arrangement on the electrode support; (ii) a cover; (iii) a spacer layer providing a sample chamber between the electrode support and the cover, at least a portion of the electrode arrangement present in the sample chamber, the sample chamber having a volume of no more than about 1 microliter; and (iv) an incompressible element placed in-between said cover and said spacer layer, the incompressible element providing an opening in at least one of the first side, the second side or in the distal end of the sample chamber to provide at least one vent in the sample chamber; (b) providing a blood sample into the sample chamber; (c) within about 10 seconds of providing the blood sample into the sample chamber, obtaining the analyte concentration. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32)
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Specification