Drop dispenser device

• US 7,922,886 B2
• Filed: 12/22/2005
• Issued: 04/12/2011
• Est. Priority Date: 12/23/2004
• Status: Active Grant

• Current Assignee: Commissariat a L'Energie Atomique (AES Corporation)
• Original Assignee: Commissariat a L'Energie Atomique (AES Corporation)
• Inventors: Jary, Dorothee, Fouillet, Yves
• Primary Examiner(s): NOGUEROLA, ALEXANDER STEPHAN
• Application Number:
  US11/722,637
• Publication Number:
  US 20080142376A1
• Time in Patent Office: 1,937 Days
• Field of Search: 204/450, 204/600
• US Class Current: 204/450
• CPC Class Codes: B01L 2200/0605 Metering of fluids
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/089 Virtual walls for guiding liquids
• CPC Class Codes: B01L 2400/0427 Electrowetting
• CPC Class Codes: B01L 3/0241 Drop counters; Drop formers making arrays for combinatorial libraries B01J19/0046; automation of dispensing for analysis G01N35/10
• CPC Class Codes: B01L 3/502792 for moving individual droplets on a plate, e.g. by locally altering surface tension
• CPC Class Codes: F04B 19/006 Micropumps F04B43/043 and F04B43/095 take precedence

Abstract

A liquid dispensing device includes first and second substrates, with the first substrate including an opening for introduction of a fluid, and the second substrate including a multiplicity of electrodes. The device includes a transfer electrode, located at least partially opposite to the opening, at least two drop-forming electrodes, and a reservoir electrode, located between the transfer electrode and the drop-forming electrodes, and with an area that is at least equal to three times the area of each drop-forming electrode.

Claims

1. A liquid dispensing device comprising:

first and second substrates, wherein the first substrate includes an opening for introduction of a fluid, and the second substrate includes a multiplicity of electrodes that include;

at least one transfer electrode, located at least partially opposite to the opening,

at least two drop-forming electrodes, and

at least one reservoir electrode, associated with the transfer electrode and with the drop-forming electrodes, and with an area that is at least equal to three times an area of each drop-forming electrode, wherein the reservoir electrode can be activated without activation of the transfer electrode, and vice versa.

2. A device according to claim 1, further comprising at least one second reservoir electrode, and at least one second transfer electrode located between, or associated with, two neighbouring reservoir electrodes, with at least two drop forming electrodes being associated with each reservoir electrode.

3. A device according to claim 2, wherein the at least one second reservoir electrode includes an area that is at least equal to three times the area of each drop-forming electrode of the drop-forming electrodes that are associated with it.

4. A device according to claim 1, further comprising at least one second reservoir electrode, and at least one second transfer electrode located at least partially opposite to the opening and at least drop-forming electrodes that are associated with the second reservoir electrode.

5. A device according to claim 4, wherein the at least one second reservoir electrode includes an area that is at least equal to three times the area of each drop-forming electrode of the drop-forming electrodes that are associated with it.

6. A device according to claim 1, wherein the at least one reservoir electrode includes an area that is at least equal to ten times the area of each drop-forming electrode of the drop-forming electrodes that are associated with it.

7. A device according to claim 1, wherein the at least one reservoir electrode includes a comb or pointed shape.

8. A device according to claim 7, wherein the comb includes tapered teeth on a side of the transfer electrode, or a point being tapered on the side of the transfer electrode.

9. A device according to claim 1, wherein the at least one reservoir electrode is star shaped.

10. A device according to claim 1, further comprising a containment wall between the at least one reservoir electrode and the opening.

11. A device according to claim 1, further comprising at least one containment wall around the at least one reservoir electrode.

12. A device according to claim 1, wherein at least one of the at least two drop-forming electrodes includes a rounded shape on one side and pointed shape on another side.

13. A device according to claim 1, wherein the first substrate includes means for conducting.

14. A device according to claim 1, wherein the first substrate includes a hydrophobic surface.

15. A device according to claim 1, wherein the second substrate includes a hydrophobic surface.

16. A device according to claim 15, wherein the second substrate includes a dielectric layer under the hydrophobic surface.

17. A liquid dispensing device comprising:

first and second substrates, wherein the first substrate includes an opening for introduction of a fluid, and the second substrate includes a multiplicity of electrodes that include;

at least one transfer electrode located at least partially opposite to the opening,

at least two drop-forming electrodes, and

at least one reservoir electrode, associated with the transfer electrode and with the drop-forming electrodes, and with an area that is at least equal to three times an area of each drop-forming electrode, wherein the reservoir electrode can be activated without activation of the transfer electrode, and vice versa; and

means for moving drops by electro-wetting, the means forming a loop.

18. A device according to claim 17, further comprising one or more secondary reservoirs arranged around the loop.

19. A device according to claim 18, wherein each secondary reservoir is connected to the loop by the at least one transfer electrode.

20. A liquid drop dispensing process that uses a device that includes,

first and second substrates, wherein the first substrate includes an opening for introduction of a fluid, and the second substrate includes a multiplicity of electrodes that include

at least one transfer electrode, located at least partially opposite to the opening,

a plurality of drop-forming electrodes, and

at least one reservoir electrode, associated with the transfer electrode and with the drop-forming electrodes, and with an area that is at least equal to three times an area of each drop-forming electrode, wherein the reservoir electrode can be activated without activation of the transfer electrode, and vice versa,

wherein the method comprises:

forming a liquid reservoir opposite to the at least one reservoir electrode;

ejecting a drop of liquid by activation of n of the drop-forming electrodes, wherein n>

2; and

then de-activating at least one of the electrodes from among the n−

1 electrodes that are closest to the at least one reservoir electrode.

21. A liquid drop dispensing process comprising:

using a device to dispense a drop, said device including

first and second substrates, wherein the first substrate includes an opening for introduction of a fluid, and the second substrate includes a multiplicity of electrodes that include

at least one transfer electrode located at least partially opposite to the opening,

at least two drop-forming electrodes, and

at least one reservoir electrode, associated with the transfer electrode and with the drop-forming electrodes, and with an area that is at least equal to three times an area of each drop-forming electrode, wherein the reservoir electrode can be activated without activation of the transfer electrode, and vice versa; and

means for moving drops by electro-wetting, the means forming a loop.

22. A process according to claim 21, further comprising transporting a formed drop along a trajectory in a shape of the loop.

23. A process according to claim 22, further comprising mixing the formed drop with one or more drops from reservoirs arranged around the loop.