Instrument
First Claim
1. A method for electrochemically determining the concentration of glucose in a blood sample, comprising:
- applying a potential to the blood sample sufficient to generate a time varying current response;
measuring the current response of the blood sample at a first time when the current response varies with the concentration of glucose and the presence of or concentration of red blood cells and has the general form;
i(t) =M/√
(t)+B where i is the current response at a given time t after applying the potential, M is the slope of a curve representing the current response, and B is the value of the current response as t becomes very large;
measuring an electrochemical response of the blood sample at a second time when the current response varies with the presence or concentration of red blood cells and is substantially insensitive to the concentration of glucose; and
determining a concentration of glucose in the blood sample based on the current response measured at the first time and corrected based on the electrochemical response determined at the second time.
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Abstract
A method and apparatus for performing a first measurement on a biological fluid or control, which first measurement varies with both the concentration of a first component and at least one of the presence and concentration of a second component. The method and apparatus perform a second measurement on the biological fluid or control, which second measurement varies primarily only with the at least one of the presence and concentration of the second component to develop an indication of the at least one of the presence and concentration of the second component. The first and second measurements may be made sequentially or simultaneously. The method and apparatus then remove an amount representative of the indicated presence or concentration of the second component from the concentration of the first component indicated by the first measurement.
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Citations
11 Claims
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1. A method for electrochemically determining the concentration of glucose in a blood sample, comprising:
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applying a potential to the blood sample sufficient to generate a time varying current response; measuring the current response of the blood sample at a first time when the current response varies with the concentration of glucose and the presence of or concentration of red blood cells and has the general form;
i(t) =M/√
(t)+Bwhere i is the current response at a given time t after applying the potential, M is the slope of a curve representing the current response, and B is the value of the current response as t becomes very large; measuring an electrochemical response of the blood sample at a second time when the current response varies with the presence or concentration of red blood cells and is substantially insensitive to the concentration of glucose; and determining a concentration of glucose in the blood sample based on the current response measured at the first time and corrected based on the electrochemical response determined at the second time. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification