Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation
First Claim
1. A method for stenting comprising the steps of:
- providing an apparatus comprising a stent having;
a web structure defining an essentially tubular member expandable from a collapsed delivery configuration toward an expanded deployed configuration;
a plurality of longitudinally adjacent web patterns defining the web structure, the web patterns having alternating concavity, two web patterns defining at least one aperture having at least two circumferentially coterminous intercommunicating substantially S-shaped portions; and
a material disposed about an exterior surface of the stent, the material comprising a multiplicity of pores, the pores having a width greater than about 30 μ
m to permit endothelization of an interior surface of the stent and less than about 100 μ
m to inhibit emboli release;
advancing the apparatus in a the collapsed delivery configuration to a treatment site within a patient'"'"'s vascular system;
deploying the apparatus to an the expanded configuration in which the apparatus engages a wall of the vascular system at the treatment site; and
promoting endothelial cell ingrowth through the multiplicity of pores to cover the interior surface of the stent while the material is configured to retain emboli at the treatment site against the wall of the vascular system.
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0 Petitions
Accused Products
Abstract
Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
300 Citations
18 Claims
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1. A method for stenting comprising the steps of:
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providing an apparatus comprising a stent having; a web structure defining an essentially tubular member expandable from a collapsed delivery configuration toward an expanded deployed configuration; a plurality of longitudinally adjacent web patterns defining the web structure, the web patterns having alternating concavity, two web patterns defining at least one aperture having at least two circumferentially coterminous intercommunicating substantially S-shaped portions; and a material disposed about an exterior surface of the stent, the material comprising a multiplicity of pores, the pores having a width greater than about 30 μ
m to permit endothelization of an interior surface of the stent and less than about 100 μ
m to inhibit emboli release;advancing the apparatus in a the collapsed delivery configuration to a treatment site within a patient'"'"'s vascular system; deploying the apparatus to an the expanded configuration in which the apparatus engages a wall of the vascular system at the treatment site; and promoting endothelial cell ingrowth through the multiplicity of pores to cover the interior surface of the stent while the material is configured to retain emboli at the treatment site against the wall of the vascular system. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for improved emboli release, comprising:
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providing a tubular expandable member having; a web structure defining an essentially tubular member expandable from a collapsed delivery configuration toward an expanded deployed configuration; a plurality of longitudinally adjacent web patterns defining the web structure, the web patterns having alternating concavity, two web patterns defining at least one aperture having at least two circumferentially coterminous intercommunicating substantially S-shaped portions; and a plurality of struts, the tubular member having an inner surface, an outer surface and proximal and distal ends, a material disposed about the outer surface of the tubular member forming a plurality of pores, the pores configured to have widths in the range of about 30 μ
m to about 100 μ
m to permit endothelization of the interior surface of the tubular member while inhibiting emboli release;advancing the tubular member in a collapsed delivery configuration to a treatment site within a patient'"'"'s vascular system; and deploying the apparatus to an expanded configuration in which the apparatus engages a wall of the vascular system at the treatment site. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A method of reducing emboli release from an interventional procedure, comprising:
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performing an interventional procedure in a patient'"'"'s vascular system at a treatment site; providing a tubular expandable member, the tubular member having; a web structure defining an essentially tubular member expandable from a collapsed delivery configuration toward an expanded deployed configuration; a plurality of longitudinally adjacent web patterns defining the web structure, the web patterns having alternating concavity, two web patterns defining at least one aperture having at least two circumferentially coterminous intercommunicating substantially S-shaped portions; and an inner surface, an outer surface and proximal and distal ends, a material disposed about the outer surface of the tubular member forming a plurality of pores having an average width of about 80 μ
m;advancing the tubular member in a collapsed delivery configuration to the treatment site within a patient'"'"'s vascular system; and deploying the tubular member to an expanded configuration in which the tubular member engages a wall of the vascular system at the treatment site. - View Dependent Claims (16, 17, 18)
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Specification