Methods for screening cells and antibodies
First Claim
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1. A method of detecting a change in a cell growth pattern comprising:
- a) applying one or more cells to a location on a surface of a colorimetric resonant reflectance optical biosensor;
b) incubating the one or more cells for a period of time or applying a test reagent or stimulus to the one or more cells;
c) detecting colorimetric resonant reflectance optical peak wavelength values (PWVs) for the location continuously over time or detecting two or more individual PWVs for the location over time; and
d) comparing the detected PWVs, wherein differences between the colorimetric resonant reflectance optical PWVs indicates a change in the cell growth pattern in the one or more cells.
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Abstract
The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.
182 Citations
9 Claims
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1. A method of detecting a change in a cell growth pattern comprising:
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a) applying one or more cells to a location on a surface of a colorimetric resonant reflectance optical biosensor; b) incubating the one or more cells for a period of time or applying a test reagent or stimulus to the one or more cells; c) detecting colorimetric resonant reflectance optical peak wavelength values (PWVs) for the location continuously over time or detecting two or more individual PWVs for the location over time; and d) comparing the detected PWVs, wherein differences between the colorimetric resonant reflectance optical PWVs indicates a change in the cell growth pattern in the one or more cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification