Sampling system for containment and transfer of ions into a spectroscopy system

• US 7,928,364 B2
• Filed: 10/15/2007
• Issued: 04/19/2011
• Est. Priority Date: 10/13/2006
• Status: Active Grant

• Current Assignee: Bruker Scientific LLC (Bruker Corporation)
• Original Assignee: IonSense, Inc. (Bruker Corporation)
• Inventors: Musselman, Brian D.
• Primary Examiner(s): Johnston; Phillip A
• Application Number:
  US11/872,666
• Publication Number:
  US 20080087812A1
• Time in Patent Office: 1,282 Days
• Field of Search: 250/285
• US Class Current: 250/285
• CPC Class Codes: H01J 49/0404 Capillaries used for transferring samples or ions electrospray nozzles H01J49/167
• CPC Class Codes: H01J 49/0418 for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates
• CPC Class Codes: H01J 49/0459 for solid samples
• CPC Class Codes: H01J 49/06 Electron- or ion-optical arrangements

Abstract

The invention provides for efficient collection of analyte ions and neutral molecules from surfaces for their subsequent analysis with spectrometry. In an embodiment of the invention, a ‘multiple desorption ionization source’ includes a tube which can contain ions for subsequent sampling within a defined spatial resolution from desorption ionization at or near atmospheric pressures. In an embodiment, electrostatic fields are used to direct ions a plurality of tubes positioned in close proximity to the surface of the sample being analyzed. In an embodiment of the present invention, either narrow inside diameter capillary tubes or wide diameter tubes can be used in combination with a vacuum inlet to draw ions and neutrals into the spectrometer for analysis. In an embodiment of the invention, a dopant is introduced into a tube to analyze the sample. In an embodiment of the invention, a plurality of ionization sources is used to analyze the sample.

Claims

1. A device for analyzing a sample comprising:

a component for generating analyte ions of the sample; and

a plurality of non coaxial tubes, wherein the plurality of non coaxial tubes have a proximal end and a distal end, wherein the proximal end of a first of the plurality of non coaxial tubes is oriented at a first angle relative to the sample, wherein the proximal end of a second of the plurality of non coaxial tubes is oriented at a second angle relative to the sample, wherein the first angle is not equal to the second angle, wherein analyte ions desorbed from the sample surface enter the proximal end of one or more of the plurality of non coaxial tubes;

wherein the distal end of the plurality of non coaxial tubes is connected with a spectrometer such that one or more analyte ions pass through the plurality of non coaxial tubes into the spectrometer.

2. The device of claim 1, wherein the proximal end of the plurality of non coaxial tubes is at a distance from the sample between:

a lower limit of approximately 10<sup>−

5</sup> m; and

an upper limit of approximately 2×

10<sup>−

1</sup> m.

3. The device of claim 1, wherein one or more of the plurality of non coaxial tubes is made from a material selected from the group consisting of metal, glass, plastic, conductively coated plastic, conductively coated fused silica, non conductively coated plastic, non conductively coated fused silica, glass lined metal tube and resistively coated glass.

4. The device of claim 1, wherein the inner diameter of one or more of the plurality of non coaxial tubes is between:

a lower limit of approximately 4×

10<sup>−

4</sup> m; and

an upper limit of approximately 10<sup>−

1</sup> m.

5. The device of claim 1, further comprising a capacitive surface, wherein one or both an inner surface of one or more of the plurality of non coaxial tubes has a capacitive surface and an outer surface of one or more of the plurality of non coaxial has a capacitive surface.

6. The device of claim 5, wherein the proximal end of the inner surface of one or more of the plurality of non coaxial tubes protrudes from the outer surface of one or more of the plurality of non coaxial tubes by a distance of between:

a lower limit of approximately 10<sup>−

4</sup> m; and

an upper limit of approximately 10<sup>−

2</sup> m.

7. The device of claim 5, wherein the proximal end of the outer surface of one or more of the plurality of non coaxial tubes protrudes from the inner surface of one or more of the plurality of non coaxial tubes by a distance of between:

a lower limit of approximately 10<sup>−

4</sup> m; and

an upper limit of approximately 10<sup>−

2</sup> m.

8. The device of claim 1, wherein the position of the proximal end of one or more of the plurality of non coaxial tubes can be adjusted relative to the sample.

9. The device of claim 1, further comprising:

the proximal end of one or more tubes of the plurality of non coaxial tubes is directed to a first area or first surface of the sample; and

the proximal end of one or more tubes of the plurality of non coaxial tubes is directed to a second area or second surface of the sample.

10. The device of claim 1, wherein one or more of the plurality of non coaxial tubes is flexible.

11. A device of claim 1, wherein the sample is one or both of a gas and a liquid injected at a distance from the proximal end of one or more non coaxial tube, where the distance is between:

a lower limit of approximately 10<sup>−

4</sup> m; and

an upper limit of approximately 10<sup>−

1</sup> m.

12. A device for analyzing a sample comprising:

a component for generating analyte ions of the sample; and

a plurality of non coaxial tubes, wherein the plurality of non coaxial tubes have a proximal end and a distal end, wherein a first of the plurality of non coaxial tubes is oriented relative to a second of the plurality of non coaxial tubes such that the first and second non coaxial tubes are not parallel, wherein analyte ions desorbed from the sample surface enter the proximal end of one or more of the plurality of non coaxial tubes;

wherein the distal end of the plurality of non coaxial tubes is connected with a spectrometer such that one or more analyte ions pass through the plurality of non coaxial tubes into the spectrometer.

13. The device of claim 12, wherein the distal end of the first of the plurality of non coaxial tubes has a smaller diameter than the proximal end of the first of the plurality of non coaxial tubes.

14. The device of claim 12, wherein the inner diameter of the first of the plurality of non coaxial tubes is between:

a lower limit of approximately 5×

10<sup>−

4</sup> m; and

an upper limit of approximately 10<sup>−

1</sup> m.

15. The device of claim 12, wherein the first of the plurality of non coaxial tubes is longer than the second of the plurality of non coaxial tubes, wherein the first and the second of the plurality of non coaxial tubes is not parallel over more than half the length of the first of the plurality of non coaxial tubes.

16. A device for analyzing a sample comprising:

a component for generating analyte ions of the sample; and

a plurality of non coaxial tubes, wherein the plurality of non coaxial tubes have a proximal end and a distal end, wherein the distal end of a first of the plurality of non coaxial tubes joins the distal end of a second of the plurality of non coaxial tubes at a merging position, wherein there is a distal end of the merged first and second non coaxial tubes, wherein the first of the plurality of non coaxial tubes makes a first angle at the merging position, wherein the second of the plurality of non coaxial tubes makes a second angle at the merging position, wherein the first angle is not equal to the second angle, wherein analyte ions desorbed from the sample surface enter the proximal end of two or more of the plurality of non coaxial tubes;

wherein the distal end of the plurality of non coaxial tubes including the distal end of the merged first and second non coaxial tubes is connected with a spectrometer;

wherein the analyte ions from the first of the plurality of non coaxial tubes merge with the analyte ions from the second of the plurality of non coaxial tubes such that one or more analyte ions pass through one or both the first and the second of non coaxial tubes and the merging position into the spectrometer.

17. The device of claim 16, wherein the position of the proximal end of the first of the plurality of non coaxial tubes can be adjusted relative to the sample.

18. The device of claim 16, further comprising:

the proximal end of the first of the plurality of non coaxial tubes is directed to one or both a first area of the sample and a first surface of the sample; and

the proximal end of the second of the plurality of non coaxial tubes is directed to one or both a second area of the sample and a second surface of the sample.

19. The device of claim 16, wherein one or more of the plurality of non coaxial tubes is flexible.

20. The device of claim 16, wherein the component for generating analyte ions of the sample is selected from the group consisting of a Direct Analysis in Real Time source, a desorption electrospray ionization (DESI), an atmospheric laser desorption ionization, a Corona discharge, an inductively coupled plasma (ICP) and a glow discharge source.