Resolution improvement in the coupling of planar differential mobility analyzers with mass spectrometers or other analyzers and detectors

• US 7,928,374 B2
• Filed: 04/11/2007
• Issued: 04/19/2011
• Est. Priority Date: 04/10/2006
• Status: Active Grant

• Current Assignee: Sociedad Europea de Analisis Diferencial de Movilidad SL
• Original Assignee: Sociedad Europea de Analisis Diferencial de Movilidad SL
• Inventors: de la Mora, Juan Fernandez, Rus-Perez, Juan
• Primary Examiner(s): Vanore; David A
• Assistant Examiner(s): MASKELL, MICHAEL P
• Application Number:
  US11/786,688
• Publication Number:
  US 20080251714A1
• Time in Patent Office: 1,469 Days
• Field of Search: 250/281, 250/282, 250/283, 250/290, 250/292
• US Class Current: 250/292
• CPC Class Codes: G01N 27/623 combined with mass spectrometry
• CPC Class Codes: H01J 49/004 Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn

Abstract

Prior work on differential mobility analysis (DMA) combined with mass spectrometry (MS) has shown how to couple the output of the DMA with the inlet of an atmospheric pressure ionization mass spectrometer (APCI-MS). However, the conventional ion inlet to an APCI-MS is a round orifice, while conventional DMA geometries make use of elongated slits. The coupling of two systems with such different symmetries limits considerably the resolutions attainable by the DMA in a DMA-MS combination below the value of the DMA alone. The purpose of this invention is to overcome this limitation in the case of a parallel plate DMA. One solution involves use of an elongated rather than a circular MS sampling hole, with the long dimension of the MS inlet hole aligned with that of the DMA slit. Another involves use of a more elongated orifice in the DMA exit and a more circular hole on the MS inlet, the two being connected either through a short transfer conduit or through an ion guide. The DMAs described can also be coupled profitably to detectors and analyzers other than mass spectrometers.

Claims

1. A method of transmitting gas carrying mobility-selected ions from the ion exhaust of a DMA with approximately planar symmetry into an inlet orifice of an analytical instrument, the method including:

providing a DMA with approximately planar symmetry and a non-circular exhaust;

arranging said non-circular exhaust such that a gas carrying mobility-selected ions emitted from said non-circular exhaust is directed towards an inlet orifice of an analytical instrument; and

operating said DMA to cause a gas carrying mobility-selected ions to emit from said non -circular exhaust towards said inlet orifice of said analytical instrument.

2. A method according to claim 1 where said inlet orifice has a non-circular cross-section.

3. A method according to claim 1 where said mobility-selected ions exiting said ion exhaust of said DMA are transmitted to said inlet orifice of said analytical instrument by a transfer line connecting on its upstream region with said non-circular exhaust of said DMA, and connecting on its downstream region with said inlet orifice of said analytical instrument, where

(i) said upstream region is more elongated than said downstream region

(ii) and the flow is not restricted within said more elongated upstream region of said transfer line but rather within either said downstream region of said transfer line, or at the exit of said transfer line, or downstream from said transfer line.

4. A method according to claim 1 where said mobility-selected ions exiting said non-circular exhaust of said DMA with approximately planar symmetry are transmitted by an ion guide to said inlet orifice of said analytical instrument, where the flow sampled into said inlet orifice is not limited upstream from it, so that the ion guide operates at a pressure close to that prevailing between the inlet and outlet slits of the DMA.

5. A method according to claim 1 where two interior surfaces of said DMA with approximately planar symmetry are formed by two conducting electrodes closing without substantial gas leakage two opposite open areas of an electrically insulating box-shaped structure, such that there is at least one junction between an upstream wetted surface on said insulating box-shaped structure and an adjacent downstream wetted surface of at least one of said conducting electrodes.

6. A method according to claim 5 where flow instabilities normally produced as the sheath gas transits through said at least one junction are avoided by placing a laminarization screen at said at least one junction, pressing tightly against one of said conducting electrodes, such that said wetted surface of said one of said conducting electrodes located downstream from said screen does not offer discontinuities to the flow.

14. A method according to claim 3, wherein said transfer line is defined in an electrode of said DMA.

15. A method according to claim 14, wherein said analytical instrument is an API-MS.

7. An approximately planar DMA apparatus to separate ions according to their electrical mobility, comprising:

i) a box-shaped insulating structure with several wide openings, including an open top surface and an open bottom surface;

ii) a top conducting electrode closing said top open surface, and a bottom conducting electrode closing said bottom open surface; and

iii) a first sealing gasket placed between said top conducting electrode and said top open surface, and a second sealing gasket placed between said bottom conducting electrode and said bottom open surface, such that substantial leakage of gas through the union of said insulating box and said conducting electrodes is avoided.

8. An apparatus according to claim 7 including one junction between an upstream wetted surface on said insulating box and an adjacent downstream wetted surface on at least one of said conducting electrodes, where flow instabilities normally produced as the sheath gas transits through said junction are avoided by (i) placing a laminarization screen at said junction;

(ii) pressing tightly said screen against said at least one conducting electrode, such that said wetted surface of said at least one conducting electrode located downstream from said screen does not offer discontinuities to the flow.

9. An apparatus according to claim 8 incorporating an elongated outlet orifice on said bottom conducting electrode.

10. An apparatus according to claim 7 operated in tandem with an analytical instrument.

11. An apparatus according to claim 10 where said ions enter into said analytical instrument through a noncircular orifice.

12. An approximately planar DMA including a shaped ion outlet conduit, said conduit having an entry section more elongated than its exit section, where the cross sectional area of said more elongated entry section is larger than the cross sectional area of said exit section, such that the flow does not become sonic within said more elongated entry section.

13. The approximately planar DMA of claim 12 coupled to a mass spectrometer.