System and method to determine hemodynamic tolerability

• US 7,930,022 B2
• Filed: 05/07/2007
• Issued: 04/19/2011
• Est. Priority Date: 05/07/2007
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Zhang, Yi, Li, Dan, Shuros, Allan C.
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Kimball; Jeremiah T
• Application Number:
  US11/745,016
• Publication Number:
  US 20080281367A1
• Time in Patent Office: 1,443 Days
• Field of Search: 607/4
• US Class Current: 607/4
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

An implantable medical device detects a tachyarrhythmia of a heart. During the detected tachyarrhythmia, the device determines a local myocardial impedance. Using the local myocardial impedance, the device determines whether there is sufficient perfusion to the heart. The device can then either deliver a less aggressive device therapy in response to the detected tachyarrhythmia when there is sufficient perfusion to the heart, or deliver a more aggressive device therapy in response to the detected tachyarrhythmia when there is insufficient perfusion to the heart. The perfusion information can also be used to alter tachyarrhythmia detection or classification.

Claims

1. A process of using an implantable medical device, the process comprising:

detecting a tachyarrhythmia of a heart using electrocardiogram (EGM) data obtained with the implantable medical device;

delivering a non-stimulatory electrical energy to a left ventricle of the heart during the detected tachyarrhythmia using an endovascular lead configured for coupling to the implantable medical device;

determining a myocardial impedance by measuring a response to the non-stimulatory electrical energy at a myocardial tissue site using the endovascular lead, wherein the delivering the non-stimulatory electrical energy includes delivering a current defining a current vector, and wherein measuring a response to the delivered non-stimulatory electrical energy includes measuring a response voltage defining a voltage vector substantially orthogonal to the current vector;

determining, during the detected tachyarrhythmia and using the myocardial impedance, information about perfusion to the heart;

delivering a less aggressive device therapy type in response to the detected tachyarrhythmia when the myocardial impedance indicates that there is sufficient perfusion to the heart; and

delivering a more aggressive device therapy type in response to the detected tachyarrhythmia when the myocardial impedance indicates that there is insufficient perfusion to the heart.

2. The process of claim 1, wherein the less aggressive therapy comprises Anti-Tachyarrhythmia Pacing (ATP) and the more aggressive therapy comprises a shock.

3. The process of claim 1, wherein determining whether there is sufficient perfusion to the heart comprises identifying a change in myocardial impedance at a particular frequency of the non-stimulatory electrical energy.

4. The process of claim 3, wherein the identifying a change in myocardial impedance includes comparing the myocardial impedance to a baseline myocardial impedance or comparing the myocardial impedance to an absolute threshold.

5. The process of claim 3, wherein the particular frequency of the non-stimulatory electrical energy comprises a frequency value that is in an inclusive range of approximately 5-30 kHz.

6. The process of claim 1, wherein determining whether there is sufficient perfusion to the heart comprises identifying an increase in myocardial impedance frequency response magnitude over a plurality of frequencies at which the non-stimulatory electrical energy is delivered to the heart.

7. The process of claim 6, wherein the plurality of frequencies comprises different frequencies within an inclusive range of between 1 kHz and 100 kHz.

8. The process of claim 1, wherein determining whether there is sufficient perfusion to the heart comprises identifying a change in myocardial impedance magnitude frequency dependence over a plurality of frequencies at which the non-stimulatory electrical energy is delivered to the heart.

9. The process of claim 8, wherein the plurality of frequencies comprises different frequencies within an inclusive range of between 1 kHz and 100 kHz.

10. The process of claim 1, wherein determining whether there is sufficient perfusion to the heart comprises identifying a change in myocardial impedance frequency response phase over a plurality of frequencies at which the non-stimulatory electrical energy is delivered to the heart.

11. The process of claim 10, wherein the plurality of frequencies comprises different frequencies within an inclusive range of between 5 kHz and 30 kHz.

12. The process of claim 1, including:

combining the EGM data relating to the detected tachyarrhythmia and impedance data relating to the perfusion into a multi-dimensional feature space including a first dimension representing an EGM-derived indication of tachyarrhythmia and a second dimension representing an impedance-derived indication of perfusion; and

calculating a decision boundary in the multi-dimensional feature space and using the decision boundary to identify and discriminate between tachyarrhythmia with sufficient perfusion and tachyarrhythmia with insufficient perfusion.

13. The process of claim 12, wherein the combined data comprises a plot of electrocardiogram data versus impedance data, and further comprising calculating an optimal decision hyperplane or a discrete classification zone in the multi-dimensional feature space.

14. The process of claim 1, comprising altering a tachyarrhythmia detection algorithm or a tachyarrhythmia classification technique as a function of the perfusion to the heart.

15. An implantable medical device comprising:

a control circuit;

a tachyarrhythmia detection circuit, coupled to the control circuit, the tachyarrhythmia detection circuit configured to detect a tachyarrhythmia of a heart using electrocardiogram (EGM) data;

an electrical energy delivery circuit, coupled to the control circuit, the electrical delivery circuit configured to deliver non-stimulatory electrical energy to a heart during a detected tachyarrhythmia;

an impedance detection circuit, coupled to the control circuit, the impedance detection circuit configured to detect, when coupled to an endovascular lead, a myocardial impedance by measuring a response to the non-stimulatory electrical energy at a myocardial tissue site using the endovascular lead, wherein the endovascular lead includes a first electrode configured to deliver the non-stimulatory electrical energy to a left ventricle and includes a second electrode to sense the response to the non-stimulatory electrical energy, and wherein the response to the non-stimulatory electrical energy is sensed in a direction orthogonal to a direction of delivery of the non-stimulatory electrical energy;

a perfusion measurement circuit, coupled to the control circuit, the perfusion measurement circuit configured to determine, during a detected tachyarrhythmia and using the myocardial impedance, whether there is sufficient perfusion to the heart; and

a therapy delivery circuit, the therapy delivery circuit configured to deliver a less aggressive therapy type in response to the detected tachyarrhythmia when the myocardial impedance indicates that there is sufficient perfusion to the heart and to deliver a more aggressive therapy type in response to the detected tachyarrhythmia when the myocardial impedance indicates that there is insufficient perfusion to the heart.

16. The implantable medical device of claim 15, wherein the therapy delivery circuit is configured to deliver Anti-Tachyarrhythmia Pacing (ATP) as the less aggressive therapy and shock as the more aggressive therapy.

17. The implantable medical device of claim 15, wherein the perfusion measurement circuit is configured to determine whether there is sufficient perfusion to the heart by identifying a change in myocardial impedance magnitude at a particular frequency of the non-stimulatory electrical energy.

18. The implantable medical device of claim 17, wherein the perfusion measurement circuit is configured to identify the change in myocardial impedance magnitude by comparing the myocardial impedance magnitude to a baseline myocardial impedance magnitude or comparing the myocardial impedance magnitude to an absolute threshold value.

19. The implantable medical device of claim 17, wherein the electrical energy delivery circuit is configured to deliver the particular frequency of the non-stimulatory electrical energy in an inclusive range of approximately 5-30 kHz.

20. The implantable medical device of claim 15, wherein the perfusion measurement circuit is configured to determine whether there is sufficient perfusion to the heart by identifying an increase in myocardial impedance frequency response magnitude over a plurality of frequencies at which the non-stimulatory electrical energy is delivered to the heart.

21. The implantable medical device of claim 20, wherein the electrical energy delivery circuit delivers the plurality of frequencies within an inclusive range of between 1 kHz and 100 kHz.

22. The implantable medical device of claim 15, wherein the perfusion measurement circuit is configured to determine whether there is sufficient perfusion to the heart by identifying a change in myocardial impedance frequency dependence over a plurality of frequencies at which the non-stimulatory electrical energy is delivered to the heart.

23. The implantable medical device of claim 22, wherein the electrical energy deliver circuit delivers the plurality of frequencies within an inclusive range of between 1 kHz and 100 kHz.

24. The implantable medical device of claim 15, wherein the perfusion measurement circuit is configured to determine whether there is sufficient perfusion to the heart by identifying a change in myocardial impedance frequency response phase over a plurality of frequencies at which the non-stimulatory electrical energy is delivered to the heart.

25. The implantable medical device of claim 24, wherein the electrical energy delivery circuit delivers the plurality of frequencies within an inclusive range of between 5 kHz and 30 kHz.

26. The implantable medical device of claim 15, wherein the electrical delivery circuit is configured to deliver the non-stimulatory electrical energy by delivering a current defining a current vector, and wherein measuring a response to the delivered non-stimulatory electrical energy includes measuring a response voltage defining a voltage vector substantially orthogonal to the current vector.

27. The implantable medical device of claim 15, wherein the tachyarrhythmia detection circuit is configured to use the perfusion to the heart for altering a technique for the detecting or classifying the tachyarrhythmia.

28. The implantable medical device of claim 15,

wherein the tachyarrhythmia detection circuit is configured to combine the EGM data relating to the detected tachyarrhythmia and impedance data relating to the perfusion into a multi-dimensional feature space including a first dimension representing an EGM-derived indication of tachyarrhythmia and a second dimension representing an impedance-derived indication of perfusion, and

wherein the perfusion measurement circuit is configured to calculate a decision boundary in the multi-dimensional feature space and to use the decision boundary to identify and discriminate between tachyarrhythmia with sufficient perfusion and tachyarrhythmia with insufficient perfusion.

29. An implantable medical device comprising:

means for detecting a tachyarrhythmia of a heart using electrocardiogram (EGM) data obtained by the implantable medical device;

means for delivering a non-stimulatory electrical energy to a left ventricle of the heart during the detected tachyarrhythmia using an endovascular lead configured to be coupled to the implantable medical device including delivering a current defining a current vector;

means for determining a myocardial impedance by measuring a response to the non-stimulatory electrical energy at a myocardial tissue site of the left ventricle using the endovascular lead including measuring a response voltage defining a voltage vector substantially orthogonal to the current vector;

means for determining, during the detected tachyarrhythmia and using the myocardial impedance, information about perfusion to the heart;

means for delivering a less aggressive device therapy type in response to the detected tachyarrhythmia when the myocardial impedance indicates that there is sufficient perfusion to the heart; and

means for delivering a more aggressive device therapy type in response to the detected tachyarrhythmia when the myocardial impedance indicates that there is insufficient perfusion to the heart.

30. The implantable medical device of claim 29, including:

means for combining the EGM data relating to the detected tachyarrhythmia and impedance data relating to the perfusion into a multi-dimensional feature space including a first dimension representing an EGM-derived indication of tachyarrhythmia and a second dimension representing an impedance-derived indication of perfusion; and

means for calculating a decision boundary in the multi-dimensional feature space and for using the decision boundary to identify tachyarrhythmia with sufficient perfusion and to identify tachyarrhythmia with insufficient perfusion.