Template initialization for evoked response detection

• US 7,930,029 B2
• Filed: 12/15/2004
• Issued: 04/19/2011
• Est. Priority Date: 12/15/2004
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Zhang, Geng
• Primary Examiner(s): Patel; Niketa I
• Assistant Examiner(s): STOKLOSA, JOSEPH A
• Application Number:
  US11/012,430
• Publication Number:
  US 20060129193A1
• Time in Patent Office: 2,316 Days
• Field of Search: 607/29, 607/9, 607/28
• US Class Current: 607/28
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold

Abstract

Methods and devices for initializing templates for evoked response detection from pacing stimulation are described. A method of generating templates characterizing a cardiac response to pacing involves determining values associated with signal features for each of a number of sensed cardiac signals following pacing pulses. The median values of the features are used to generate a cardiac response template.

Claims

1. A method of operating an implantable cardiac device to characterize a cardiac response to pacing, comprising:

delivering a plurality of captured pacing pulses to a heart chamber that capture the heart chamber;

sensing a captured cardiac signal following delivery of each captured pacing pulse, each captured cardiac signal associated with a captured pacing response;

measuring a captured peak amplitude value and a captured peak timing value of each captured cardiac signal;

determining a median value of the captured peak timing values;

determining a captured peak threshold from the measured captured peak amplitude values;

delivering a plurality of non-captured pacing pulses to the heart chamber that do not capture the heart chamber;

sensing a non-captured cardiac signal following delivery of each non-captured pacing pulse, each non-captured cardiac signal associated with a non-captured pacing response;

measuring a non-captured peak amplitude value for each non-captured cardiac signal;

determining a non-captured peak threshold from the measured non-captured peak amplitude values;

comparing a peak timing of a cardiac signal of a subsequent paced cardiac cycle to the median value of the captured peak timing values;

comparing a peak amplitude of the cardiac signal of the subsequent paced cardiac cycle to the captured peak amplitude threshold and the noncaptured peak amplitude threshold;

determining the cardiac response to pacing of the heart chamber for the subsequent paced cardiac cycle based on comparing the peak timing of the cardiac signal to the median value of the captured peak timing values and comparing the peak amplitude of the cardiac signal to the captured peak amplitude threshold and the non-captured peak amplitude threshold; and

providing pacing therapy according to the cardiac pacing response determination.

2. The method of claim 1, wherein delivering the captured pacing pulses comprises jittering the pacing rate at which the captured pacing pulses are delivered.

3. The method of claim 2, wherein jittering the pacing rate comprises randomly jittering the pacing rate.

4. The method of claim 1, wherein determining the cardiac pacing response comprises:

detecting capture if the peak amplitude of the cardiac signal exceeds the captured peak amplitude threshold; and

detecting non-capture if the peak amplitude of the cardiac signal does not exceed the non-captured peak amplitude threshold.

5. The method of claim 1, wherein determining the median value of the captured peak timing values comprises:

(a) determining first median values of the captured peak timing values;

(b) checking for convergence of the first median values;

(c) if the first median values are determined to converge, then determining the median value of the captured peak timing values based on the converging first median values; and

(d) if the first median values are determined not to converge, then delivering one or more additional captured pacing pulses to the heart chamber, sensing one or more additional captured cardiac signals following delivery of the one or more additional captured pacing pulses, measuring one or more additional captured peak timing values of the one or more additional captured cardiac signals, determining at least one additional first median value of the captured peak timing values, and repeating at least procedures (b), (c), and (d).

6. The method of claim 5, further comprising:

measuring a non-captured peak timing value for each non-captured cardiac signal;

determining a median value of the non-captured peak timing values, including;

(e) determining second median values of the non-captured peak timing values;

(f) checking for convergence of the second median values;

(g) if the second median values are determined to converge, then determining a median value of the non-captured peak timing values based on the converging second median values; and

(h) if the second median values are determined not to converge, then delivering one or more additional non-captured pacing pulses to the heart chamber, sensing one or more additional non-captured cardiac signals following delivery of the one or more additional non-captured pacing pulses, measuring one or more additional non-captured peak timing values of the one or more additional non-captured cardiac signals, determining at least one additional second median value of the non-captured peak timing values, and repeating at least procedures (f), (g), and (h); and

wherein determining the cardiac response to pacing of the heart chamber for the subsequent paced cardiac cycle includes determining the cardiac response using the median value of the non-captured peak timing values.

7. The method of claim 1,

wherein determining the median value of the captured peak timing values comprises repetitively determining a plurality of median captured peak timing values;

wherein the method further includes calculating an average value of the median captured peak timing values

wherein determining the cardiac response to pacing of the heart chamber for the subsequent paced cardiac cycle includes determining the cardiac response to pacing of the heart chamber for the subsequent paced cardiac cycle based on the average value of the median captured peak timing values.

8. The method of claim 1, further comprising:

ranking the captured peak timing values;

identifying extreme values from the ranking; and

discarding the extreme values before determining the median of the captured peak timing values.

9. The method of claim 1, further comprising:

sensing each cardiac signal prior to delivering each pacing pulse;

determining a baseline from the cardiac signal sensed prior to the pacing pulse; and

measuring each captured peak amplitude value and each non-captured peak amplitude value referenced from the baseline.

10. The method of claim 1, wherein delivering the plurality of captured pacing pulses and delivering the plurality of non-captured pacing pulses comprises consecutively delivering a captured pacing pulse and a non-captured pacing pulse.

12. The method of claim 1, further comprising

sensing a pre-pace cardiac signal before delivery of each pacing pulse;

determining a baseline from the pre-pace cardiac signal, wherein the peak amplitude value is referenced from the baseline.

11. A method of operating an implantable cardiac device to characterize a cardiac response to pacing, comprising:

delivering captured and non-captured pacing pulses to a heart chamber;

sensing a post-pace cardiac signal after delivery of each pacing pulse;

measuring a peak amplitude value and a peak timing value from each post-pace cardiac signal;

determining a median value from the peak amplitude values;

determining a median value from the peak timing values;

generating a template using the median values;

using the template to determine the cardiac response to subsequent pacing pulses; and

providing pacing therapy according to the cardiac pacing response determination.

13. The method of claim 11, further comprising iteratively determining one or more of the median values until convergence is achieved.

14. An implantable cardiac device, comprising:

a pacing circuit configured to deliver captured and non-captured pacing pulses to a heart chamber;

a sensing circuit configured to sense a post-pace cardiac signal after delivery of each pacing pulse;

a template processor configured to measure a peak amplitude value and a peak timing value from each post-pace cardiac signal, determine a captured peak threshold value and a non-captured peak threshold value, determine at least one median value from the peak timing values, and generate a template using the median value and the threshold values;

a cardiac response classification processor configured to use the template to determine the cardiac response to pacing for subsequent paced cardiac cycles; and

a pacing therapy controller configured to control delivery of pacing therapy according to the cardiac pacing response determination.