Miniature pump for drug delivery
First Claim
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1. An infusion device for use in delivering drugs, the device comprising:
- a) a housing having a chamber, the housing having an outlet;
b) a diaphragm operatively connected to the housing, the diaphragm dividing the chamber into a drug storage subchamber and a propellant subchamber, the diaphragm constructed from a shape memory alloy material, the diaphragm is configured to go over center for greater volume efficiencies;
c) the propellant subchamber adapted and configured to receive a suitable propellant;
d) the shape memory alloy selected for low bending stresses, wherein significant pressure changes are not imparted to the drug storage subchamber; and
e) the drug storage subchamber adapted and configured to receive a suitable drug, the drug storage subchamber having an outlet in fluid communication with the outlet of the housing.
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Abstract
A miniature drug delivery pump utilizes a shape memory Ni—Ti alloy. A flow restrictor is provided and the pump is refillable.
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Citations
22 Claims
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1. An infusion device for use in delivering drugs, the device comprising:
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a) a housing having a chamber, the housing having an outlet; b) a diaphragm operatively connected to the housing, the diaphragm dividing the chamber into a drug storage subchamber and a propellant subchamber, the diaphragm constructed from a shape memory alloy material, the diaphragm is configured to go over center for greater volume efficiencies; c) the propellant subchamber adapted and configured to receive a suitable propellant; d) the shape memory alloy selected for low bending stresses, wherein significant pressure changes are not imparted to the drug storage subchamber; and e) the drug storage subchamber adapted and configured to receive a suitable drug, the drug storage subchamber having an outlet in fluid communication with the outlet of the housing. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 19, 20)
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16. An infusion device for use in delivering drugs, the device comprising:
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a housing having a chamber, the housing having an outlet; b) a diaphragm operatively connected to the housing, the diaphragm dividing the chamber into a drug storage subchamber and a propellant subchamber, the diaphragm constructed from a shape memory alloy, the diaphragm is configured to go over center for greater volume efficiencies; c) the propellant subchamber adapted and configured to receive a suitable propellant; d) the shape memory alloy selected for low bending stresses, wherein significant pressure changes are not imparted to the drug storage subchamber; e) the drug storage subchamber adapted and configured to receive a suitable drug, the drug storage subchamber having an outlet in fluid communication with the outlet of the housing; and f) a flow restrictor having a first end in fluid communication with the outlet of the drug storage subchamber and a second end in fluid communication with the housing outlet, the flow restrictor being a micro-machined flow restrictor, the flow restrictor comprising; i) a first glass member having a planar top surface; ii) a second glass member having a planar bottom surface, the bottom surface of the second glass member positioned on the top surface of the first glass member to form a chip assembly; iii) one of the top surface and bottom surface having a channel machined thereon; and iv) the chip assembly having an inlet in fluid communication with the drug storage subchamber outlet and an outlet in fluid communication with the housing outlet. - View Dependent Claims (17, 18, 21, 22)
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Specification