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Compositions and methods for the preparation of human growth hormone glycosylation mutants

  • US 7,932,364 B2
  • Filed: 05/07/2004
  • Issued: 04/26/2011
  • Est. Priority Date: 05/09/2003
  • Status: Expired due to Fees
First Claim
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1. An isolated human growth hormone polypeptide comprising the amino acid sequence of SEQ ID NO:

  • 1 or SEQ ID NO;

    2 except for the presence of at least one O-linked glycosylation site not present in SEQ ID NO;

    1 or SEQ ID NO;

    2, wherein the O-linked glycosylation site is a serine or threonine residue, and wherein the O-linked glycosylation site is present at a site selected from the group consisting of (a) proximate a proline residue located at position 2, 5, 37, 48, 59, 89, or 133 of SEQ ID NO;

    1 or SEQ ID NO;

    2, (b) the amino acid sequence surrounding position 140 of SEQ ID NO;

    1 or SEQ ID NO;

    2, and (c) the amino acid sequence at the C-terminus of SEQ ID NO;

    1 or SEQ ID NO;

    2.

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