Biomolecule bonding detection apparatus using RF wireless energy transmission and method thereof

• US 7,933,720 B2
• Filed: 12/21/2005
• Issued: 04/26/2011
• Est. Priority Date: 01/11/2005
• Status: Expired due to Fees

• Current Assignee: Samsung Electronics Co. Ltd.
• Original Assignee: Samsung Electronics Co. Ltd.
• Inventors: Kang, Jung-ho, Park, Tae-sik, Kim, Young-il
• Primary Examiner(s): Dejong; Eric S
• Application Number:
  US11/315,526
• Publication Number:
  US 20060154282A1
• Time in Patent Office: 1,952 Days
• Field of Search: None
• US Class Current: 702/19
• CPC Class Codes: G01N 27/3276 being a hybridisation with immobilised receptors using a FET type sensor G01N27/4145; concerning the hybridisation C12Q1/68
• CPC Class Codes: G01N 33/48785 Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply

Abstract

An apparatus for detecting a biomolecule bonding using a radio frequency (RF) wireless energy transmission and a method thereof are disclosed. The method includes transmitting RF energy to a sensor module having one or more probe biomolecules immobilized thereon, and determining a first energy charging time of the sensor module, the first energy charging time representing the amount of time for the sensor to be completely charged by the transmitted RF energy, prior to mixing of the one or more probe biomolecules with one or more target sample biomolecules. A second energy charging time of the sensor module is determined, the second energy charging time representing the amount of time for the sensor to be completely charged by the transmitted RF energy, following mixing of the one or more probe biomolecules with one or more target biomolecule sample. A determination of whether biomolecule bonding has occurred is based on a variation of the first and second energy charging times.

Claims

1. A biomolecule bonding detection method, comprising:

transmitting RF energy to a sensor module having one or more probe biomolecules immobilized thereon;

determining a first energy charging time of the sensor module, the first energy charging time representing the amount of time for the sensor module to be completely charged by the transmitted RF energy, prior to mixing of the one or more probe biomolecules with one or more target sample biomolecules;

determining a second energy charging time of the sensor, the second energy charging time representing the amount of time for the sensor to be completely charged by the transmitted RF energy, following mixing of the one or more probe biomolecules with one or more target biomolecule sample; and

determining whether biomolecule bonding has occurred based on a variation of the first and second energy charging times.

2. The biomolecule bonding detection method of claim 1, wherein the RF energy transmitted to the sensor module is received by a rectifying antenna (rectenna) included therein, the RF energy rectified to a direct current and used as operating power for the sensor module.

3. The biomolecule bonding detection method of claim 2, wherein the RF energy is transmitted to the rectenna by an antenna included within a main body of a biomolecule bonding detection apparatus, the apparatus also including the sensor module.

4. The biomolecule bonding detection method of claim 2, wherein the main body stores the time at which energy transmission to the sensor module begins, and wherein the main body receives a charging completion signal sent by the sensor module when the sensor module is completely charged, the main body further recording the time at which the charging completion signal is received.

5. The biomolecule bonding detection method of claim 4, wherein the first and second energy charging times are calculated from respective energy transmission times and charge completion times.

6. The biomolecule bonding detection method of claim 2, wherein the main body transmits, along with the RF energy, the time at which energy transmission to the sensor module begins, and wherein the main body receives the energy transmission time back from the sensor module, along with a charging completion signal sent by the sensor module when the sensor module is completely charged, the main body further recording the time at which the charging completion signal is received.

7. The biomolecule bonding detection method of claim 6, wherein the first and second energy charging times are calculated from respective energy transmission times and charge completion times.

8. A biomolecule bonding detection apparatus comprising:

a sensor module including a rectifying antenna for receiving radio frequency energy, the rectifying antenna having one or more probe biomolecules immobilized thereon; and

a main body having an antenna for transmitting the radio frequency energy to the rectifying antenna, the main body configured to detect whether a biomolecule bonding has occurred by determining a difference in charging time of the sensor module by the transmitted radio frequency energy before and after the one or more probe biomolecules are mixed with one or more target sample biomolecules.

9. The biomolecule bonding detection apparatus of claim 8, wherein the sensor module includes:

a generator for generating a charging completion signal when the sensor module is charged, wherein the rectifying antenna is further configured to transmit the charging completion signal to the antenna in the main body; and

a power supply for enabling the radio frequency energy to be used as operating power for the sensor module.

10. The biomolecule bonding detection apparatus of claim 9, wherein the power supply includes a rectifier for rectifying the radio frequency energy to a direct current.

11. The biomolecule bonding detection apparatus of claim 9, wherein the rectifying antenna receives energy transmitting time information from the antenna, and transmits the received energy transmitting time information back to the antenna when the charging completion signal is transmitted to the antenna.

12. The biomolecule bonding detection apparatus of claim 9, wherein:

the antenna of the main body is configured for transmitting the energy to the rectifying antenna and for receiving the charging completion signal from the rectifying antenna; and

the main body further includes an analyzer for analyzing the difference in charging time of the sensor module by using the energy transmitting time information initially stored therein when the energy is first transmitted to the rectifying antenna, and by using the time at which the charging completion signal is received from the rectifying antenna.

13. The biomolecule bonding detection apparatus of claim 9, wherein:

the antenna of the main body is configured for transmitting both the radio frequency energy and an energy transmitting time to the rectifying antenna, and for receiving the charging completion signal from the rectifying antenna, and for receiving the energy transmitting time information back from the rectifying antenna; and

the main body further includes an analyzer for analyzing the difference in charging time of the sensor module by using the energy transmitting time from the rectifying antenna, and by using the time at which the charging completion signal is received from the rectifying antenna.