Antibodies to IL-6 and use thereof
First Claim
1. An anti-human IL-6 antibody or antibody fragment comprising a variable light chain comprising the CDR 1 sequence of SEQ ID NO:
- 4, the CDR 2 sequence of SEQ ID NO;
5, and the CDR 3 sequence of SEQ ID NO;
6, and a variable heavy chain comprising the CDR 1 sequence of SEQ ID NO;
7, the CDR 2 sequence of SEQ ID NO;
8 or SEQ ID NO;
120, and the CDR 3 sequence of SEQ ID NO;
9.
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0 Petitions
Accused Products
Abstract
The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.
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Citations
28 Claims
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1. An anti-human IL-6 antibody or antibody fragment comprising a variable light chain comprising the CDR 1 sequence of SEQ ID NO:
- 4, the CDR 2 sequence of SEQ ID NO;
5, and the CDR 3 sequence of SEQ ID NO;
6, and a variable heavy chain comprising the CDR 1 sequence of SEQ ID NO;
7, the CDR 2 sequence of SEQ ID NO;
8 or SEQ ID NO;
120, and the CDR 3 sequence of SEQ ID NO;
9. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26)
- 4, the CDR 2 sequence of SEQ ID NO;
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2. An anti-human IL-6 antibody or antibody fragment comprising the variable heavy chain in SEQ ID NO:
- 2, 18 or 19 and the variable light chain contained in SEQ ID NO;
3 or 20.
- 2, 18 or 19 and the variable light chain contained in SEQ ID NO;
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3. An anti-human IL-6 antibody or antibody fragment which comprises the variable heavy chain in SEQ ID NO:
- 19 and the variable light chain contained in SEQ ID NO;
20. - View Dependent Claims (27)
- 19 and the variable light chain contained in SEQ ID NO;
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25. An anti-human IL-6 antibody or antibody fragment which comprises the variable heavy chain in SEQ ID NO:
- 18 and the variable light chain contained in SEQ ID NO;
20. - View Dependent Claims (28)
- 18 and the variable light chain contained in SEQ ID NO;
Specification