Glycerophospholipids for the improvement of cognitive functions

• US 7,935,365 B2
• Filed: 06/24/2008
• Issued: 05/03/2011
• Est. Priority Date: 10/22/2003
• Status: Active Grant

• Current Assignee: Enzymotec USA (International Flavors & Fragrances Incorporated)
• Original Assignee: Enzymotec Limited (International Flavors & Fragrances Incorporated)
• Inventors: Bar-On, Zohar, Zuabi, Rassan, Shulman, Avidor, Dror, Gai Ben, Pelled, Dori, Farkash, Orly, Richter, Yael, Platt, Dorit
• Primary Examiner(s): Wax; Robert A
• Assistant Examiner(s): Sasan; Aradhana
• Application Number:
  US12/215,080
• Publication Number:
  US 20090074857A1
• Time in Patent Office: 1,043 Days
• Field of Search: 424/439, 424/456, 514/120
• US Class Current: 424/456
• CPC Class Codes: A21D 2/32 Phosphatides
• CPC Class Codes: A23D 7/013 Spread compositions
• CPC Class Codes: A23D 9/013 Other fatty acid esters, e.g. phosphatides
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/30 Dietetic or nutritional methods, e.g. for losing weight A23L33/10 takes precedence
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/322 having an effect on the health of the nervous system or on mental function
• CPC Class Codes: A23V 2250/1842 Lecithin
• CPC Class Codes: A23V 2250/1882 Polyunsaturated fatty acids
• CPC Class Codes: A23V 2250/1942 Long-chain triglycerides
• CPC Class Codes: A61K 31/201 having one or two double bonds, e.g. oleic, linoleic acids
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61K 31/66 Phosphorus compounds
• CPC Class Codes: A61K 31/685 one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
• CPC Class Codes: A61K 47/544 Phospholipids
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/14 for treating abnormal movements, e.g. chorea, dyskinesia
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/22 : Anxiolytics
• CPC Class Codes: A61P 25/24 : Antidepressants
• CPC Class Codes: A61P 25/28 : for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: C07F 9/10 : Phosphatides, e.g. lecithin

Abstract

This invention provides a preparation comprising serine glycerophospholipids which comprise a mixture of serine glycerophospholipids comprising eicosapentaenoic acid (EPA) and serine glycerophospholipids comprising docosahexaenoic acid (DHA), wherein each such serine glycerophospholipid comprising EPA and each such serine glycerophospholipid comprising DHA has the formula (I):

wherein R″ is serine; wherein one of R or R′ is acyl EPA or acyl DHA and the other of R or R′ is hydrogen or an acyl group; wherein the combined amount of EPA and DHA present in such mixture of serine glycerophospholipids constitutes 10-50% by weight of the total fatty acids content of the serine glycerophospholipids in said preparation; and wherein the mixture is not identical to naturally occurring human or mammalian brain PS.

Claims

1. A preparation comprising serine glycerophospholipids which comprise a mixture of serine glycerophospholipids comprising eicosapentaenoic acid (EPA) and serine glycerophospholipids comprising docosahexaenoic acid (DHA), wherein each such serine glycerophospholipid comprising EPA and each such serine glycerophospholipid comprising DHA has the formula (I):

2. The preparation of claim 1, wherein the percent by weight of EPA is lower than the percent by weight of DHA in said mixture of serine glycerophospholipids.

3. The preparation of claim 1, wherein said mixture of serine glycerophospholipids is prepared by enzymatic transphosphatidylation of a lipid source selected from the group consisting of a marine, a plant, an animal and a microorganism source.

4. A pharmaceutical composition comprising the preparation of claim 1, and a pharmaceutically acceptable additive, diluent or excipient.

5. The pharmaceutical composition of claim 4, further comprising an additional pharmaceutically active agent.

6. The pharmaceutical composition of claim 4, wherein said composition is in the form of a tablet, capsule, injectable or patch.

7. A nutraceutical composition comprising the preparation of claim 1.

8. The nutraceutical composition of claim 7, in the form of a softgel capsule, tablet, syrup, or other dietary supplement delivery system.

9. A functional food article comprising the preparation of claim 1.

10. The food article of claim 9, wherein said article is a dairy product, ice cream, biscuit, soy product, cake, pastry, bread, sauce, soup, prepared food, instant food, frozen food, condiment, confectionary, oil, fat, margarine, spread, filling, cereal, instant product, drink, shake, infant formula, infant food, mashed fruit, vegetable, cereal, bar, snack, candy or chocolate product.