Calcium Potassium Ferrocyanide, a prophylactic mixture comprising this compound and the use thereof for decorporation of Radiocesium in subjects affected by nuclear radiation

• US 7,935,366 B2
• Filed: 01/10/2006
• Issued: 05/03/2011
• Est. Priority Date: 01/10/2005
• Status: Expired due to Fees

• Current Assignee: The Secretary, Department Of Atomic Energy
• Original Assignee: The Secretary, Department Of Atomic Energy
• Inventors: Pahuja, Dharampal Nandiram, Sonawane, Vinay Ramkrishna, Jagtap, Vikram Sarjerao
• Primary Examiner(s): Arnold; Ernst V
• Application Number:
  US11/794,781
• Publication Number:
  US 20080145448A1
• Time in Patent Office: 1,939 Days
• Field of Search: None
• US Class Current: 424/687
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/10 Carbonates; Bicarbonates
• CPC Class Codes: A61K 33/18 Iodine; Compounds thereof
• CPC Class Codes: A61K 33/26 Iron; Compounds thereof
• CPC Class Codes: A61P 39/02 Antidotes
• CPC Class Codes: A61P 39/04 Chelating agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C01C 3/12 Simple or complex iron cyanides

Abstract

A new prophylactic mixture is prepared for the effective decorporation of *Cs, *Sr, *I from affected subjects in the event of an accidental release of the radioisotopes in the environment due to any nuclear accident. The prophylactic mixture comprising: 1) Calcium Potassium Ferrocyanide [CaK₂Fe(CN)₆] 2) Calcium Iodate, and 3) Calcium Carbonate, can be formulated in the form of a single tablet, capsule or suspension for easy administration to the radiation affected subjects in cases of emergency or nuclear fallout. Also claimed are the compound calcium potassium ferrocyanide (CaK₂Fe(CN)₆) and the use thereof for decorporation of *Cs in subjects affected by nuclear radiation.

Claims

1. A method comprising:

administering Calcium Potassium Ferrocyanide CaK₂[Fe(CN)₆], wherein administering is effective for decorporating radiocesium from an in-vivo system.

2. A prophylactic composition for oral administration for the simultaneous decorporation of radiocesium, radiostrontium and radioiodine from in vivo milieu of subjects affected by the exposure to nuclear radiation, said composition comprising calcium carbonate, calcium iodate and calcium potassium ferrocyanide.

3. A prophylactic composition as claimed in claim 2, comprising 1000-1500 mg calcium carbonate, 45-65 mg calcium iodate and 900-1100 mg calcium potassium ferrocyanide.

4. A prophylactic composition as claimed in claim 3 comprising 1100-1400 mg calcium carbonate, 50-60 mg calcium iodate and 950-1050 mg calcium potassium ferrocyanide.

5. A prophylactic composition as claimed in claim 4, comprising 1200-1300 mg calcium carbonate, 52-56 mg calcium iodate and 980-1020 mg calcium potassium ferrocyanide.

6. A prophylactic composition as claimed in claim 2, wherein said composition is in the form of suspension, tablets or capsules.

7. A prophylactic composition as claimed in claim 6, wherein said composition is formulated in the form of a suspension in 12-15 ml of water, soda, soft drink or fruit juice.

8. A prophylactic composition as claimed in claim 6, wherein said composition is in the form of tablets.

9. A prophylactic composition as claimed in claim 6, wherein said composition is in the form of capsules.

10. A prophylactic composition as claimed in claim 2, wherein 2-4 tablets or capsules or chewable tablets are administered to a human subject once a day.

11. A prophylactic composition as claimed in claim 2, wherein said composition is formulated in smaller doses comprising 50% by weight of each of the said constituents to be suitable to children.

12. A prophylactic composition as claimed in claim 11, comprising 500-750 mg of calcium carbonate, 20-35 mg of calcium iodate and 450-550 mg of calcium potassium ferrocyanide.

13. A prophylactic composition as claimed in claim 12, comprising 550-700 mg of calcium carbonate, 25-30 mg of calcium iodate and 475-525 mg of calcium potassium ferrocyanide.

14. A prophylactic composition as claimed in claim 11, wherein 2 to 4 tablets or capsules or chewable tablets of said composition provide the dosage to be administered to a child once a day.

15. A method comprising:

administering a composition comprising calcium potassium ferrocyanide ([CaK₂Fe(CN)₆]), calcium iodate and calcium carbonate for the simultaneous decorporation of radiocesium, radiostrontium and radioiodine from in vivo milieu of subjects affected by the exposure to nuclear radiation.