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Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements

  • US 7,935,520 B2
  • Filed: 06/25/2009
  • Issued: 05/03/2011
  • Est. Priority Date: 10/30/2000
  • Status: Expired due to Fees
First Claim
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1. A biosensor comprising:

  • an optical grating having a first and a second surface, the optical grating comprised of an optically transparent material that conducts electricity;

    the optical grating being replicated from a master grating structure by causing a liquid to harden after dispensing the liquid between the master grating structure and a substrate layer, wherein the optical grating comprises the hardened liquid, and wherein the second surface of the optical grating is in contact with the substrate layer, and wherein the optical grating comprises features having a depth and a cross-sectional period;

    wherein the first surface of the optical grating is coated with an electrical insulator, wherein when the biosensor is illuminated a resonant grating effect is produced on the reflected radiation spectrum, wherein the depth and the cross-sectional period of the optical grating are less than the wavelength of the resonant grating effect.

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