Thiophene and benzothiophene hydroxamic acid derivatives
First Claim
1. A compound represented by the following structural Formula:
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to a novel class of hydroxamic acid derivatives having a benzothiophene or thiophene backbone. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit historic deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases, The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.
-
Citations
17 Claims
- 1. A compound represented by the following structural Formula:
-
16. A compound selected from:
-
6-Phenylacetylamino-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-Benzoylamino-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(Biphenyl-4-carbonyl)-amino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(3-Phenyl-propionylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(Naphthalene-2-carbonyl)-amino]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-Isobutyrylamino-benzo[b]thiophene-2-carboxylic acid hydroxyamide; Quinoline-2-carboxylic acid (2-hydroxycarbamoyl-benzo[b]thiophen-6-yl)-amide; N-(2-Hydroxycarbamoyl-benzo [b]thiophen-6-yl)-nicotinamide; 6-Diphenylacetylamino-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(Naphthalene- 1 -carbonyl)-amino]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-(3,4-Dimethoxy-benzoylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[2-(3,4-Dimethoxy-phenyl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[2-(4-Fluoro-phenyl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[2-(2,5-Dimethoxy-phenyl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[2-(3-Methoxy-phenyl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[2-(4-Chloro-phenyl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[2-(4-Methoxy-phenyl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(2-Phenyl-butyrylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(Methyl-phenylacetyl-amino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(2-Pyridin-2-yl-acetylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(2-Pyridin-3-yl-acetylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(2-Phenyl-propionylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-{[1-(4-Chloro-phenyl)-cyclopropanecarbonyl]-amino}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(1-Phenyl-cyclopropanecarbonyl)-amino]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-{[1-(4-Chloro-phenyl)-cyclobutanecarbonyl]-amino}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[2-(4-Chloro-phenyl)-2-methyl-propionylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(2S-Phenyl-butyrylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(2R-Phenyl-butyrylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(Benzoylamino-methyl)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(Phenylacetylamino-methyl)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-{[(Naphthalene-1-carbonyl)-amino]-methyl}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(2-Methyl-benzoylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(4-Methyl-benzoylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(3-Methoxy-benzoylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(4-Methoxy-benzoylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(3,4-Dimethoxy-benzoylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; N-(2-Hydroxycarbamoyl-benzo[b]thiophen-6-ylmethyl)-nicotinamide; 6-(Isobutyrylamino-methyl)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(2-Methoxy-benzoylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(4-Chloro-benzoylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-Phenylmethanesulfonylamino-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-Benzenesulfonylamino-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(Biphenyl-4-sulfonylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(Naphthalene-1-sulfonylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(Naphthalene-2-sulfonylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(Toluene-4-sulfonylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(Benzenesulfonylamino-methyl)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(Phenylmethanesulfonylamino-methyl)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(Naphthalene-1-sulfonylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(Naphthalene-2-sulfonylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(Toluene-4-sulfonylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(2,4,6-Trimethyl-benzenesulfonylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(4-tert-Butyl-benzenesulfonylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(4-Fluoro-benzenesulfonylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(4-Chloro-benzenesulfonylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(3-Chloro-benzenesulfonylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(4-Bromo-benzenesulfonylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(3-Bromo-benzenesulfonylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(3-Methoxy-benzenesulfonylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(4-Nitro-benzenesulfonylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(4-Methoxy-benzenesulfonylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(Thiophene-2-sulfonylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-{[3-(4-Methoxy-phenoxy)-propane-1-sulfonylamino]-methyl}-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-(3-Benzyl-ureido)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; (2-Hydroxycarbamoyl-benzo[b]thiophen-6-yl)-carbamic acid ethyl ester; (2-Hydroxycarbamoyl-benzo[b]thiophen-6-yl)-carbamic acid benzyl ester; 6-(3-Phenethyl-ureido)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(3-Benzyl-ureidomethyl)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; (2-Hydroxycarbamoyl-benzo[b]thiophen-6-ylmethyl)-carbamic acid benzyl ester; 6-[3-(4-Isopropyl-phenyl)-ureidomethyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[3-(4-tert-Butyl-phenyl)-ureidomethyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureidomethyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[3 -(3-Phenoxy-phenyl)-ureidomethyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-Benzoylamino-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-Phenylacetylamino-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-(3-Phenyl-propionylamino)-benzo [b] thiophene-2-carboxylic acid hydroxyamide; 5-(3-Phenyl-acryloylamino)-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 5-[(Naphthalene-1-carbonyl)-amino]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 5-[(Naphthalene-2-carbonyl)-amino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; Quinoline-2-carboxylic acid (2-hydroxycarbamoyl-benzo[b]thiophen-5-yl)-amide; N-(2-Hydroxycarbamoyl-benzo[b]thiophen-5-yl)-nicotinamide; 5-[(Biphenyl-4-carbonyl)-amino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-Diphenylacetylamino-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-Isobutyrylamino-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-[2-(4-Fluoro-phenyl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-[2-(3-Methoxy-phenyl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-[2-(3,4-Dimethoxy-phenyl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-[2-(2,5-Dimethoxy-phenyl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-(2-Phenyl-butyrylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-[2-(4-Chloro-phenyl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-[2-(4-Methoxy-phenyl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-{[1-(4-Chloro-phenyl)-cyclopentanecarbonyl]-amino}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-(Naphthalene-2-sulfonylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-(Toluene-4-sulfonylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-Benzenesulfonylamino-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-Phenylmethanesulfonylamino-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-(Naphthalene-1-sulfonylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-(Biphenyl-4-sulfonylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; (2-Hydroxycarbamoyl-benzo[b]thiophen-5-yl)-carbamic acid benzyl ester; (2-Hydroxycarbamoyl-benzo[b]thiophen-5-yl)-carbamic acid ethyl ester; 5-(3-Benzyl-ureido)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-Dibenzylamino-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-Dibenzylamino-benzo[b]thiophene-2-carboxylic acid methyl ester; 6-Dibenzylamino-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-(Bis-phenylcarbamoylmethyl-amino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(Bis-phenylcarbamoylmethyl-amino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[2-(4-Phenyl-piperazin-1-yl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(2-3,4-Dihydro-1H-isoquinolin-2-yl-acetylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[2-(4-Benzyl-piperidin-1-yl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 4-[(2-Hydroxycarbamoyl-benzo[b]thiophen-6-ylcarbamoyl)-methyl]-piperazine-1-carboxylic acid benzyl ester; 6-(2-Dibenzylamino-acetylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-{2-[4(3 -Methoxy-phenyl)-piperazin-1-yl]-acetylamino}-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[2-(4-Pyrimidin-2-yl-piperazin-1-yl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-{2-[4-(2-(2-Methoxy-phenyl)-piperazin- 1 -yl]-acetylamino}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[2-(4-Pyridin-2-yl-piperazin-1-yl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[2-(4-Acetyl-piperazin-1-yl)-acetylamino]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(2-Piperidin-1-yl-acetylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(2-Morpholin-4-yl-acetylamino)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[2-(Benzyl-phenethyl-amino)-acetylamino]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; {tert-Butoxycarbonylmethyl-[(2-hydroxycarbamoyl-benzo[b]thiophen-6-ylcarbamoyl)-methyl]-amino}-acetic acid tert-butyl ester; 6-{2-[4-(2-Chloro-phenyl)-piperazin-1-yl]-acetylamino}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-{2-[4-(3-Chloro-phenyl)-piperazin-1-yl]-acetylamino}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 4-[(2-Hydroxycarbamoyl-benzo[b]thiophen-6-ylcarbamoyl)-methyl]-[1,4]diazepane-1-carboxylic acid benzyl ester; 4-[(2-Hydroxycarbamoyl-benzo[b]thiophen-6-ylcarbamoyl)-methyl]-piperazine-1-carboxylic acid ethyl ester; 6-{2-[4(4-Methoxy-phenyl)-piperazin-1-yl]-acetylamino}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; Benzo[b]thiophene-2,6-dicarboxylic acid 2-hydroxyamide 6-{[2-(1H-indol-2-yl)-ethyl]-amide}; Benzo[b]thiophene-2,6-dicarboxylic acid 6-benzylamide 2-hydroxyamide; Benzo[b]thiophene-2,6-dicarboxylic acid 2-hydroxyamide 6-[(pyridin-2-ylmethyl)-amide]; Benzo[b]thiophene-2,6-dicarboxylic acid 6-[(1-benzyl-piperidin-4-yl)-amide]2-hydroxyamide; Benzo[b]thiophene-2,6-dicarboxylic acid 6-[(2,2-diphenyl-ethyl)-amide]2-hydroxyamide; Benzo[b]thiophene-2,6-dicarboxylic acid 6-[(1,2-diphenyl-ethyl)-amide]2-hydroxyamide; Benzo[b]thiophene-2,6-dicarboxylic acid 6-benzhydryl-amide 2-hydroxyamide; Benzo[b]thiophene-2,6-dicarboxylic acid 6-[(1H-benzoimidazol-2-ylmethyl)-amide]2-hydroxyamide; Benzo[b]thiophene-2,6-dicarboxylic acid 2-hydroxyamide 6-[(2-pyridin-2-yl-ethyl)-amide]; Benzo[b]thiophene-2,6-dicarboxylic acid 2-hydroxyamide 6-[(1,2,3,4-tetrahydro-naphthalen-1-yl)-amide]; 6-(Piperidine-1-carbonyl)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; Benzo[b]thiophene-2,6-dicarboxylic acid 2-hydroxyamide 6-phenylamide; Benzo[b]thiophene-2,6-dicarboxylic acid 2-hydroxyamide 6-indan-1-ylamide; 6-(4-Phenyl-piperazine- 1-carbonyl)-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[4-(4-Chloro-phenyl)-piperazine-1-carbonyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; Benzo[b]thiophene-2,6-dicarboxylic acid 2-hydroxyamide 6-[(3-phenyl-propyl)-amide]; Benzo[b]thiophene-2,6-dicarboxylic acid 2-hydroxyamide 6-(phenethyl-amide); 6-(4-Benzyl-piperidine- 1-carbonyl)-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-(4-Benzyl-piperazine- 1-carbonyl)-benzo [b]thiophene-2-carboxylic acid hydroxyamide; Benzo[b]thiophene-2,6-dicarboxylic acid 2-hydroxyamide 6-quinolin-8-ylamide; Benzo[b]thiophene-2,6-dicarboxylic acid 2-hydroxyamide 6-[(4-phenyl-thiazol-2-yl)-amide]; Benzo[b]thiophene-2,5-dicarboxylic acid 2-hydroxyamide 5-(2-methoxy-benzylamide); Benzo[b]thiophene-2,5-dicarboxylic acid 2-hydroxyamide 5-(3-methoxy-benzylamide); Benzo[b]thiophene-2,5-dicarboxylic acid 2-hydroxyamide 5-(4-methoxy-benzylamide); Benzo [b]thiophene-2,5-dicarboxylic acid 5-(2-chloro-benzylamide) 2-hydroxyamide; Benzo [b]thiophene-2,5-dicarboxylic acid 5-(3-chloro-benzylamide) 2-hydroxyamide; Benzo [b]thiophene-2,5-dicarboxylic acid 5-(4-chloro-benzylamide) 2-hydroxyamide; Benzo [b]thiophene-2,5-dicarboxylic acid 2-hydroxyamide 5-indan-1-ylamide; Benzo [b]thiophene-2,5-dicarboxylic acid 2-hydroxyamide 5-{[2-(1H-indol-3-yl)-ethyl]-amide}; Benzo [b]thiophene-2,5-dicarboxylic acid 5-[(3,3-diphenyl-propyl)-amide]2-hydroxyamide; Benzo [b]thiophene-2,5-dicarboxylic acid 2-hydroxyamide 5-[(4-phenyl-butyl)-amide]; Benzo [b]thiophene-2,5-dicarboxylic acid 2-hydroxyamide 5-phenylamide; Benzo [b]thiophene-2,5-dicarboxylic acid 2-hydroxyamide 5-(phenethyl-amide); Benzo [b]thiophene-2,5-dicarboxylic acid 5-benzylamide 2-hydroxyamide; Benzo [b]thiophene-2,5-dicarboxylic acid 2-hydroxyamide 5-[(3-phenyl-propyl)-amide]; Benzo [b]thiophene-2,5-dicarboxylic acid 5-(bis-phenylcarbamoylmethyl-amide) 2-hydroxyamide; 5-[(3-Methoxy-benzylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 5-(Benzylamino-methyl)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-Phenylaminomethyl-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-[(3-Benzyloxy-phenylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-[(4-Methoxy-benzylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 5-[(2-Chloro-benzylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 5-[(4-Chloro-benzylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 5-[(Benzhydryl-amino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-(Phenethylamino-methyl)-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 5-[(2,2-Diphenyl-ethylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 5-{[2-(3,4-Bis-benzyloxy-phenyl)-ethylamino]-methyl}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-[(3-Phenyl-propylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 5-[(3,3-Diphenyl-propylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-[(4-Phenyl-butylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-[(2-Morpholin-4-yl-ethylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-[(Cyclohexylmethyl-amino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 5-[(2-Methoxy-benzylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 5-[(3-Chloro-benzylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 5-{[(1H-Benzoimidazol-2-ylmethyl)-amino]-methyl}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-{[(Pyridin-2-ylmethyl)-amino]-methyl}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-{[2-(3,4-Dimethoxy-phenyl)-ethylamino]-methyl}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-{[2-(1H-Indol-3-yl)-ethylamino]-methyl}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 5-[(1-Benzyl-piperidin-4-ylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(Benzylamino-methyl)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(2-Methoxy-benzylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(3-Methoxy-benzylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-Phenylaminomethyl-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(Phenethylamino-methyl)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(3-Phenyl-propylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(2-Chloro-benzylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(3-Chloro-benzylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(4-Chloro-benzylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-{[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-methyl}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-(Indan-1-ylaminomethyl)-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(9H-Fluoren-9-ylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(1,2-Diphenyl-ethylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(Cyclohexylmethyl-amino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(1,2,3,4-Tetrahydro-naphthalen-1-ylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-{[2-(2-Methyl-1H-indol-3-yl)-ethylamino]-methyl}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-{[(Pyridin-2-ylmethyl)-amino]-methyl}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(1-Benzyl-piperidin-4-ylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-[(4-Methoxy-benzylamino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-{[2-(1H-Indol-3-yl)-ethylamino]-methyl}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(4-Methoxy-benzylamino)-methyl]-benzo[b]thiophene-2-carboxylic acid ethyl ester; 6-{[Cyclohexyl-(4-methoxy-benzyl)-amino]-methyl}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-{[(4-Methoxy-b enzyl)-(tetrahydro-pyran-4-yl)-amino]-methyl}-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-{[(2-Hydroxy-ethyl)-(4-methoxy-benzyl)-amino]-methyl}-benzo [b]thiophene-2-carboxylic acid hydroxyamide; 6-{[Isopropyl-(4-methoxy-benzyl)-amino]-methyl}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-{[(4-Methoxy-benzyl)-methyl-amino]-methyl}-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(Acetyl-benzyl-amino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide; 6-[(Benzyl-methanesulfonyl-amino)-methyl]-benzo [b]thiophene-2-carboxylic acid hydroxyamide; and N-Hydroxy-N′
-(2-hydroxycarbamoyl-benzo [b]thiophen-6-yl)-oxalamide;
or a stereoisomer, enantiomer, racemate, pharmaceutically acceptable salt, solvate, hydrate or polymorph thereof.
-
Specification