Dynamic nerve stimulation employing frequency modulation
First Claim
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1. An implantable medical device that outputs a configured electrical signal effective to modulate a nerve in a mammal;
- wherein the electrical signal comprises;
a stimulation intensity pattern that varies at least one of a current amplitude and a pulse width in the signal; and
a stimulation frequency pattern that varies frequency in the signal;
wherein the combination of the stimulation intensity pattern and the stimulation frequency pattern in the electrical signal, as applied to a nerve in the mammal, is effective to result in at least one of a loss of fat mass and a gain in lean mass of the mammal.
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Abstract
Described are apparatus and methods for electrically modulating a nerve in a mammal. An electrical signal that includes a signal intensity pattern and a signal frequency pattern is delivered to a nerve. The combination of the signal intensity pattern and the signal frequency pattern is effective to result in weight loss, fat loss, and/or lean-mass gain, in a mammal. In some embodiments the nerve is modulated in response to a physiological parameter. In some embodiments, the physiological parameter is measured by a sensor.
285 Citations
54 Claims
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1. An implantable medical device that outputs a configured electrical signal effective to modulate a nerve in a mammal;
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wherein the electrical signal comprises; a stimulation intensity pattern that varies at least one of a current amplitude and a pulse width in the signal; and a stimulation frequency pattern that varies frequency in the signal; wherein the combination of the stimulation intensity pattern and the stimulation frequency pattern in the electrical signal, as applied to a nerve in the mammal, is effective to result in at least one of a loss of fat mass and a gain in lean mass of the mammal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A method of electrically modulating a nerve in a mammal, comprising:
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configuring an electrical signal to comprise; a stimulation intensity pattern that varies at least one of a current amplitude and a pulse width in the signal; and a stimulation frequency pattern that varies frequency in the signal; and applying the electrical signal to a nerve in the mammal; wherein the combination of the stimulation intensity pattern and the stimulation frequency pattern in the electrical signal, as applied to a nerve in the mammal, is effective to result in at least one of a loss of fat mass and a gain in lean mass of the mammal. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
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Specification