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Dissolution testing with in-situ gravimetric volume measurement

  • US 7,938,032 B2
  • Filed: 10/30/2008
  • Issued: 05/10/2011
  • Est. Priority Date: 10/30/2008
  • Status: Active Grant
First Claim
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1. A dissolution test apparatus, comprising:

  • a vessel support member including a plurality of vessel mounting sites for supporting a plurality of vessels, each vessel mounting site having an aperture for receiving a vessel;

    a plurality of weight sensors, at least one weight sensor located at each vessel mounting site, each weight sensor positioned to contact a vessel received in the respective aperture and configured to transmit a measurement signal indicative of the weight of the vessel and any contents therein;

    a movable component positioned above the vessel support member;

    a media transport cannula supported by the movable component and movable thereby to at least one selected vessel mounting site;

    a pump assembly communicating with the media transport cannula and configured to establish media flow between the media transport cannula and a vessel mounted at the aperture of the selected vessel mounting site; and

    an electronic controller communicating with the plurality of weight sensors, the electronic controller configured to receive the measurement signals from the weight sensors and, based on the received measurement signals, calculate volumes of media in the vessels associated with the received measurement signals.

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